175135-47-4

• 常用中文名：O4I1
• 常用英文名：O4I1
• CAS号：175135-47-4
• 分子式：C₁₆H₁₅NO₂
• 分子量：253.296
• 相关类别： 信号通路 干细胞及 Wnt 通路 OCT3/4
• 发布时间：2018-10-18 11:42:13
• 更新时间：2024-01-03 10:30:18
• O4I1是一种有效的Oct3/4诱导剂。

名称

• 中文名: 2-(4-[(4-甲氧基苄基)氧基]苯基)乙腈
• 英文名: 2-[4-[(4-methoxyphenyl)methoxy]phenyl]acetonitrile
• 英文别名: 2-[4-[(4-Methoxyphenyl)methoxy]phenyl]-acetonitrile; 4-(4-methoxybenzyloxy)benzylnitrile; Benzeneacetonitrile, 4-[(4-methoxyphenyl)methoxy]-; {4-[(4-Methoxybenzyl)oxy]phenyl}acetonitrile; O4I1; 2-(4-((4-Methoxybenzyl)oxy)phenyl)acetonitrile; 2-(4-[(4-METHOXYBENZYL)OXY]PHENYL)ACETONITRILE; O4I-1

物化性质

• 密度: 1.1±0.1 g/cm3
• 沸点: 424.5±30.0 °C at 760 mmHg
• 熔点: 140ºC
• 分子式: C₁₆H₁₅NO₂
• 分子量: 253.296
• 闪点: 154.8±17.8 °C
• 精确质量: 253.110275
• PSA: 42.25000
• LogP: 2.93
• 外观性状: light yellow solid
• 蒸汽压: 0.0±1.0 mmHg at 25°C
• 折射率: 1.570
• 储存条件: -20℃

生物活性

• 描述: O4I1是一种有效的Oct3/4诱导剂。
• 相关类别:
  信号通路 >> 干细胞及 Wnt 通路 >> OCT3/4
  研究领域 >> 其他
• 参考文献:

  [1]. Cheng X, et al. Identification of 2-[4-[(4-Methoxyphenyl)methoxy]-phenyl]acetonitrile and Derivatives as Potent Oct3/4 Inducers. J Med Chem. 2015 Jun 25;58(12):4976-4983.

  [2]. Mrowka, et al. Method for activating OCT4 for induction of pluripotent stem cell formation. From PCT Int. Appl. (2014), WO 2014000814 A1 20140103.

MSDS

Name: 2-{4-[(4-methoxybenzyl)oxy]phenyl}acetonitrile 97% Material Safety Data Sheet Synonym: CAS: 175135-47-4 Section 1 - Chemical Product MSDS Name:2-{4-[(4-methoxybenzyl)oxy]phenyl}acetonitrile 97% Material Safety Data Sheet Synonym: Section 2 - COMPOSITION, INFORMATION ON INGREDIENTS CAS# Chemical Name content EINECS# 175135-47-4 2-{4-[(4-Methoxybenzyl)oxy]phenyl}acet 97% unlisted Hazard Symbols: XN Risk Phrases: 20/21/22 Section 3 - HAZARDS IDENTIFICATION EMERGENCY OVERVIEW Harmful by inhalation, in contact with skin and if swallowed. Potential Health Effects Eye: May cause eye irritation. Skin: May cause skin irritation. Harmful if absorbed through the skin. Ingestion: Harmful if swallowed. May cause irritation of the digestive tract. Inhalation: Harmful if inhaled. May cause respiratory tract irritation. Chronic: Not available. Section 4 - FIRST AID MEASURES Eyes: Flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical aid. Skin: Get medical aid. Flush skin with plenty of water for at least 15 minutes while removing contaminated clothing and shoes. Ingestion: Get medical aid. Wash mouth out with water. Inhalation: Remove from exposure and move to fresh air immediately. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get medical aid. Notes to Physician: Section 5 - FIRE FIGHTING MEASURES General Information: As in any fire, wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. Extinguishing Media: Use water spray, dry chemical, carbon dioxide, or chemical foam. Section 6 - ACCIDENTAL RELEASE MEASURES General Information: Use proper personal protective equipment as indicated in Section 8. Spills/Leaks: Vacuum or sweep up material and place into a suitable disposal container. Section 7 - HANDLING and STORAGE Handling: Avoid breathing dust, vapor, mist, or gas. Avoid contact with skin and eyes. Storage: Store in a cool, dry place. Store in a tightly closed container. Section 8 - EXPOSURE CONTROLS, PERSONAL PROTECTION Engineering Controls: Use adequate ventilation to keep airborne concentrations low. Exposure Limits CAS# 175135-47-4: Personal Protective Equipment Eyes: Not available. Skin: Wear appropriate protective gloves to prevent skin exposure. Clothing: Wear appropriate protective clothing to prevent skin exposure. Respirators: Follow the OSHA respirator regulations found in 29 CFR 1910.134 or European Standard EN 149. Use a NIOSH/MSHA or European Standard EN 149 approved respirator if exposure limits are exceeded or if irritation or other symptoms are experienced. Section 9 - PHYSICAL AND CHEMICAL PROPERTIES Physical State: Solid Color: pale yellow Odor: Not available. pH: Not available. Vapor Pressure: Not available. Viscosity: Not available. Boiling Point: Not available. Freezing/Melting Point: 140 - 141 deg C Autoignition Temperature: Not available. Flash Point: Not available. Explosion Limits, lower: Not available. Explosion Limits, upper: Not available. Decomposition Temperature: Solubility in water: Specific Gravity/Density: Molecular Formula: C16H15NO2 Molecular Weight: 253 Section 10 - STABILITY AND REACTIVITY Chemical Stability: Not available. Conditions to Avoid: Incompatible materials. Incompatibilities with Other Materials: Oxidizing agents. Hazardous Decomposition Products: Hydrogen cyanide, nitrogen oxides, carbon monoxide, carbon dioxide. Hazardous Polymerization: Has not been reported Section 11 - TOXICOLOGICAL INFORMATION RTECS#: CAS# 175135-47-4 unlisted. LD50/LC50: Not available. Carcinogenicity: 2-{4-[(4-Methoxybenzyl)oxy]phenyl}acetonitrile - Not listed by ACGIH, IARC, or NTP. Section 12 - ECOLOGICAL INFORMATION Section 13 - DISPOSAL CONSIDERATIONS Dispose of in a manner consistent with federal, state, and local regulations. Section 14 - TRANSPORT INFORMATION IATA Shipping Name: NITRILES, SOLID, TOXIC, N.O.S.* Hazard Class: 6.1 UN Number: 3276 Packing Group: III IMO Shipping Name: NITRILES, TOXIC, N.O.S. Hazard Class: 6.1 UN Number: 3276 Packing Group: III RID/ADR Shipping Name: NITRILES, TOXIC, N.O.S. Hazard Class: 6.1 UN Number: 3276 Packing group: III Section 15 - REGULATORY INFORMATION European/International Regulations European Labeling in Accordance with EC Directives Hazard Symbols: XN Risk Phrases: R 20/21/22 Harmful by inhalation, in contact with skin and if swallowed. Safety Phrases: S 36/37 Wear suitable protective clothing and gloves. WGK (Water Danger/Protection) CAS# 175135-47-4: No information available. Canada None of the chemicals in this product are listed on the DSL/NDSL list. CAS# 175135-47-4 is not listed on Canada's Ingredient Disclosure List. US FEDERAL TSCA CAS# 175135-47-4 is not listed on the TSCA inventory. It is for research and development use only. SECTION 16 - ADDITIONAL INFORMATION N/A

安全

• 危害码 (欧洲): Xn:Harmful;
• 风险声明 (欧洲): R20/21/22
• 安全声明 (欧洲): S36/37
• 海关编码: 2926909090

海关

海关编码	2926909090
中文概述	2926909090 其他腈基化合物. 增值税率:17.0% 退税率:9.0% 监管条件:无 最惠国关税:6.5% 普通关税:30.0%
申报要素	品名, 成分含量, 用途
Summary	HS:2926909090 other nitrile-function compounds VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:30.0%