29050-11-1

• 常用中文名：司克拉宗
• 常用英文名：Seclazone
• CAS号：29050-11-1
• 分子式：C₁₀H₈ClNO₃
• 分子量：225.62800
• 相关类别： 研究领域 炎症/免疫
• 发布时间：2018-03-11 08:00:00
• 更新时间：2024-01-02 16:52:02
• Seclazone 是一种杂环化合物, 具有抗炎、镇痛、解热和利尿的特性。Seclazone 具有口服活性。

名称

• 中文名: 司克拉宗
• 英文名: 7-chloro-3,3a-dihydro-2H-[1,2]oxazolo[3,2-b][1,3]benzoxazin-9-one
• 英文别名: Seclazonum [INN-Latin]; 3,3a-Dihydro-7-chloro-2H,9H-isoxazolo(3,2-b)(1,3)benzoxazin-9-one; Seclazona [INN-Spanish]; Seclazone; 7-chloro-3,3a-dihydro-2H-benzo[e]isoxazolo[3,2-b][1,3]oxazin-9-one; W-2354

物化性质

• 分子式: C₁₀H₈ClNO₃
• 分子量: 225.62800
• 精确质量: 225.01900
• PSA: 38.77000
• LogP: 1.77390

生物活性

• 描述: Seclazone 是一种杂环化合物, 具有抗炎、镇痛、解热和利尿的特性。Seclazone 具有口服活性。
• 相关类别:
  信号通路 >> 其他 >> 其他
  研究领域 >> 炎症/免疫
• 体内研究: Seclazone(220 mg/kg；p.o.；膳食,每日)抑制佐剂诱导的大鼠多关节炎的发展[1]。Seclazone显著降低酵母悬浮液给药引起的大鼠发热[1]。动物模型：雄性Charles River大鼠(150-170g)[1]剂量：220mg/kg给药：口服,饮食,每日结果：抑制佐剂诱导的多关节炎
• 参考文献:

  [1]. F M Berger, et al. The pharmacological properties of seclazone (7-chloro-3,3a-dihydro-2H, 9H-isoxazolo (3,2-b) (1,3) benzoxazin-9-one) a new anti-inflammatory agent. Pharmacology. 1973;9(3):164-76.

毒性和生态

CHEMICAL IDENTIFICATION RTECS NUMBER : NY3170000 CHEMICAL NAME : 2H,9H-Isoxazolo(3,2-b)(1,3)benzoxazin-9-one, 3,3a-dihydro-7-chloro- CAS REGISTRY NUMBER : 29050-11-1 LAST UPDATED : 199612 DATA ITEMS CITED : 7 MOLECULAR FORMULA : C10-H8-Cl-N-O3 MOLECULAR WEIGHT : 225.64 HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 1550 mg/kg TOXIC EFFECTS : Behavioral - somnolence (general depressed activity) Behavioral - convulsions or effect on seizure threshold Behavioral - ataxia REFERENCE : PHMGBN Pharmacology: International Journal of Experimental and Clinical Pharmacology. (S. Karger AG, Postfach CH-4009 Basel, Switzerland) V.1- 1968- Volume(issue)/page/year: 9,164,1973 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 375 mg/kg TOXIC EFFECTS : Behavioral - somnolence (general depressed activity) Behavioral - convulsions or effect on seizure threshold Behavioral - ataxia REFERENCE : PHMGBN Pharmacology: International Journal of Experimental and Clinical Pharmacology. (S. Karger AG, Postfach CH-4009 Basel, Switzerland) V.1- 1968- Volume(issue)/page/year: 9,164,1973 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 475 mg/kg TOXIC EFFECTS : Behavioral - somnolence (general depressed activity) Behavioral - convulsions or effect on seizure threshold Behavioral - ataxia REFERENCE : PHMGBN Pharmacology: International Journal of Experimental and Clinical Pharmacology. (S. Karger AG, Postfach CH-4009 Basel, Switzerland) V.1- 1968- Volume(issue)/page/year: 9,164,1973 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 400 mg/kg TOXIC EFFECTS : Behavioral - somnolence (general depressed activity) Behavioral - convulsions or effect on seizure threshold Behavioral - ataxia REFERENCE : PHMGBN Pharmacology: International Journal of Experimental and Clinical Pharmacology. (S. Karger AG, Postfach CH-4009 Basel, Switzerland) V.1- 1968- Volume(issue)/page/year: 9,164,1973 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Mammal - dog DOSE/DURATION : 200 mg/kg TOXIC EFFECTS : Behavioral - convulsions or effect on seizure threshold Behavioral - fluid intake Behavioral - ataxia REFERENCE : PHMGBN Pharmacology: International Journal of Experimental and Clinical Pharmacology. (S. Karger AG, Postfach CH-4009 Basel, Switzerland) V.1- 1968- Volume(issue)/page/year: 9,164,1973 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Primate - monkey DOSE/DURATION : >400 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : PHMGBN Pharmacology: International Journal of Experimental and Clinical Pharmacology. (S. Karger AG, Postfach CH-4009 Basel, Switzerland) V.1- 1968- Volume(issue)/page/year: 9,164,1973 ** OTHER MULTIPLE DOSE TOXICITY DATA ** TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 67200 mg/kg/48W-I TOXIC EFFECTS : Nutritional and Gross Metabolic - changes in sodium Nutritional and Gross Metabolic - changes in chlorine Related to Chronic Data - death REFERENCE : TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 25,444,1973

合成路线

37551-43-2 ~% 29050-11-1

文献：Reisner; Ludwig; Stiefel; Gister; Meyer; Powell; Sofia Arzneimittel-Forschung/Drug Research, 1977 , vol. 27, # 4 p. 760 - 766

29050-04-2 ~% 29050-11-1

文献：Reisner; Ludwig; Stiefel; Gister; Meyer; Powell; Sofia Arzneimittel-Forschung/Drug Research, 1977 , vol. 27, # 4 p. 760 - 766

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