68498-25-9

• 常用中文名：N6-乙烯基2'-脱氧腺苷
• 常用英文名：N6-Etheno 2'-deoxyadenosine
• CAS号：68498-25-9
• 分子式：C₁₂H₁₃N₅O₃
• 分子量：275.26300
• 相关类别： 信号通路 细胞周期/DNA损伤 核苷抗代谢药/类似物
• 发布时间：2017-02-21 21:50:12
• 更新时间：2026-07-16 13:22:11
• N6-Etheno 2'-deoxyadenosine 是一种由活性氧/活性氮诱导的 DNA 氧化损伤产物,可作为一种生物指标,来评估动物或人组织中慢性炎症和脂质过氧化。

名称

• 中文名: N6-乙烯基2'-脱氧腺苷
• 英文名: Etheno-2'-deoxy-β-D-adenosine
• 中文别名: 亚乙烯基-2'-脱氧腺苷; N6-亚乙烯基-2'-脱氧腺苷; 乙烯脱氧腺苷; (2R,3S,5R)-2-(羟甲基)-5-(3H-咪唑并[2,1-I]嘌呤-3-基)四氢呋喃-3-醇; 乙烯-2'-脱氧-Β-D-腺苷
• 英文别名: N,1-Etheno-2'-deoxyadenosine; Etheno-2’-deoxy-β-D-adenosine; Ccris; 6-(2-Deoxy-β-D-ribofuranosyl)-1,3a,5,6,8-pentaaza-3aH,6H-as-indacene; 3H-Imidazo(2,1-I)purine, 3-(2-deoxy-beta-D-erythro-pentofuranosyl); 3H-Imidazo[2,1-i]purine,3-(2-deoxy-b-D-erythro-pentofuranosyl); 1,N6-Etheno-dA; ETHENO-2'-DEOXYADENOSINE, MORPURE HPLC PURIFIED, DELIVERED >= UV CHROMATOAM; 1,N6-ETHENO-2'-DEOXY-ADENOSINE; Etheno-2’-deoxy-Beta-D-adenosine; 1,n-ethenodeoxyadenosine; 1,N(sup 6)-etheno-2'-deoxyadenosine; 3-(2-Deoxy-β-D-erythro-pentofuranosyl)-3H-iMidazo[2,1-i]purine; N,1-(Ethene-1,2-diyl)-1,6-dihydro-6,N-didehydro-2'-deoxyadenosine; 3-(2-Deoxy-beta-D-erythro-pentofuranosyl)-3H-imidazo(2,1-I)purine; 2ˊ-Deoxy-1,N6-ethenoadenosine; 3-(2-Deoxy-β-D-ribofuranosyl)-3H-imidazo[2,1-i]purine; ETHENO-2'-DEOXYADENOSINE; 3H-Imidazo[2,1-i]purine, 3-(2-deoxy-D-ery); N1,N6-Etheno-2'-deoxyadenosine; N6-Etheno-2'-deoxyadenosine; 3H-Imidazo[2,1-i]purine, 3-(2-deoxy-β-D-erythro-pentofuranosyl); (2R,3S,5R)-2-(Hydroxymethyl)-5-(3H-imidazo[2,1-i]purin-3-yl)tetrahydrofuran-3-ol; 1,N6-Etheno-2'-deoxyadenosine; Ethenodeoxyadenosine

物化性质

• 密度: 1.85 g/cm3
• 分子式: C₁₂H₁₃N₅O₃
• 分子量: 275.26300
• 精确质量: 275.10200
• PSA: 97.70000
• 折射率: 1.876

生物活性

• 描述: N6-Etheno 2'-deoxyadenosine 是一种由活性氧/活性氮诱导的 DNA 氧化损伤产物,可作为一种生物指标,来评估动物或人组织中慢性炎症和脂质过氧化。
• 相关类别:
  信号通路 >> 细胞周期/DNA损伤 >> 核苷抗代谢药/类似物
  研究领域 >> 炎症/免疫
• 参考文献:

  [1]. Gao L, et al. DNA Product Formation in Female Sprague-Dawley Rats Following Polyhalogenated Aromatic Hydrocarbon (PHAH) Exposure. Chem Res Toxicol. 2017 Mar 20;30(3):794-803.

安全

• 个人防护装备: Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
• 危险品运输编码: NONH for all modes of transport

合成路线

107-20-0 958-09-8 ~90% 68498-25-9

文献：Chirakul; Litzer; Sigurdsson Nucleosides, Nucleotides and Nucleic Acids, 2001 , vol. 20, # 12 p. 1903 - 1913

20838-22-6 ~% 68498-25-9

文献：Journal of the American Chemical Society, , vol. 117, # 43 p. 10781 - 10782

60-33-3 958-09-8 ~% 68498-25-9 103560-62-9

文献：Environmental Toxicology, , vol. 22, # 2 p. 222 - 227

4546-72-9 ~% 68498-25-9

文献：Nucleosides, Nucleotides and Nucleic Acids, , vol. 20, # 12 p. 1903 - 1913

13875-63-3 951-77-9 ~96% 68498-25-9

文献：Mueller, Michael; Hutchinson, Linda K.; Peter Guengerich Chemical Research in Toxicology, 1996 , vol. 9, # 7 p. 1140 - 1144

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