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7299-11-8

7299-11-8 structure
7299-11-8 structure
  • Name: Psoromic Acid
  • Chemical Name: 10-formyl-9-hydroxy-3-methoxy-4,7-dimethyl-6-oxobenzo[b][1,4]benzodioxepine-1-carboxylic acid
  • CAS Number: 7299-11-8
  • Molecular Formula: C18H14O8
  • Molecular Weight: 358.30
  • Catalog: Research Areas Metabolic Disease
  • Create Date: 2018-08-29 10:39:37
  • Modify Date: 2024-01-02 22:33:40
  • Psoromic acid is a potent and selective RabGGTase (Rab geranylgeranyl transferase) inhibitor with an IC50 value of 1.3 µM. Psoromic acid is an antioxidative agent. Psoromic acid exhibits a competitive type of HMGR inhibition and mixed type of ACE (angiotensin converting enzyme) inhibition[1][2].
Name 10-formyl-9-hydroxy-3-methoxy-4,7-dimethyl-6-oxobenzo[b][1,4]benzodioxepine-1-carboxylic acid
Synonyms Parellic acid
Psoromsaeure
psoromic acid
Description Psoromic acid is a potent and selective RabGGTase (Rab geranylgeranyl transferase) inhibitor with an IC50 value of 1.3 µM. Psoromic acid is an antioxidative agent. Psoromic acid exhibits a competitive type of HMGR inhibition and mixed type of ACE (angiotensin converting enzyme) inhibition[1][2].
Related Catalog
Target

IC50: 1.3 µM (RabGGTase)[1]

References

[1]. Deraeve C, et al. Psoromic acid is a selective and covalent Rab-prenylation inhibitor targeting autoinhibited RabGGTase. J Am Chem Soc. 2012 May 2;134(17):7384-91.  

[2]. Behera BC, et al. Antioxidative and cardiovascular-protective activities of metabolite usnic acid and psoromic acid produced by lichen species Usnea complanata under submerged fermentation. Pharm Biol. 2012 Aug;50(8):968-79.  

Density 1.483 g/cm3
Boiling Point 641.7ºC at 760 mmHg
Molecular Formula C18H14O8
Molecular Weight 358.30
Flash Point 237ºC
Exact Mass 358.06900
PSA 119.36000
LogP 2.85320
Index of Refraction 1.658

CHEMICAL IDENTIFICATION

RTECS NUMBER :
HP3082200
CHEMICAL NAME :
11H-Dibenzo(b,e)(1,4)dioxepin-6-carboxylic acid, 4-formyl-3-hydroxy-8-methoxy-1,9-dimethyl- 11-oxo-
CAS REGISTRY NUMBER :
7299-11-8
LAST UPDATED :
198308

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
200 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
85GDA2 "CRC Handbook of Antibiotic Compounds," Vols.1- , Berdy, J., Boca Raton, FL, CRC Press, 1980- Volume(issue)/page/year: 9,55,1982
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
12 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
85GDA2 "CRC Handbook of Antibiotic Compounds," Vols.1- , Berdy, J., Boca Raton, FL, CRC Press, 1980- Volume(issue)/page/year: 9,55,1982
60441-77-2 structure

60441-77-2

~%

7299-11-8 structure

7299-11-8

Literature: Shanghai Institute of Materia Medica, Chinese Academy of Sciences Patent: EP2199295 A1, 2010 ; Location in patent: Page/Page column 18 ;
Precursor  1

DownStream  0


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