148857-42-5

• 常用中文名：(S)-2-(3-氯-2-羟基丙基)异吲哚-1,3-二酮
• 常用英文名：(S)-2-(3-chloro-2-hydroxypropyl)isoindoline-1,3-dione
• CAS号：148857-42-5
• 分子式：C₁₁H₁₀ClNO₃
• 分子量：239.655
• 发布时间：2016-08-13 19:41:06
• 更新时间：2024-01-12 17:59:15

名称

• 中文名: (S)-2-(3-氯-2-羟基丙基)异吲哚-1,3-二酮
• 英文名: 2-[(2S)-3-Chloro-2-hydroxypropyl]-1H-isoindole-1,3(2H)-dione
• 英文别名: 3-chloro-1-phenylmethylamino-2-hydroxypropane; N-(3-chloro-2-hydroxypropyl)phthalimide; (-)-2-(3-chloro-2-hydroxypropyl)-1H-isoindole-1,3(2H)-dione; 1-(N-benzyl)amino-3-chloro-2-propanol; (RS)-1-chloro-3-phthalimidopropan-2-ol; 1-(benzylamino)-3-chloro-2-propanol; 1-chloro-3-benzylpropan-2-ol; 2-Propanol,1-chloro-3-[(phenylmethyl)amino]; (+/-)-1-chloro-3-phthalimido-2-propanol; (S)-1-phthalimido-3-chloro-2-propanol; 1H-Isoindole-1,3(2H)-dione, 2-[(2S)-3-chloro-2-hydroxypropyl]-; 2-[(2S)-3-Chloro-2-hydroxypropyl]-1H-isoindole-1,3(2H)-dione; rac-1-phthalimido-3-chloro-2-propanol; N-(3-chloro-2-hydroxypropyl)benzylamine; 1-(benzylamino)-3-chloropropan-2-ol; N-benzyl-3-chloro-2-hydroxypropylamine; 3-(Benzylamino)-1-chloro-2-propanol; (S)-2-(3-chloro-2-hydroxypropyl)isoindoline-1,3-dione; Rivaroxaban Impurity 53

物化性质

• 密度: 1.4±0.1 g/cm3
• 沸点: 405.4±35.0 °C at 760 mmHg
• 分子式: C₁₁H₁₀ClNO₃
• 分子量: 239.655
• 闪点: 199.0±25.9 °C
• 精确质量: 239.034927
• PSA: 57.61000
• LogP: 1.63
• 蒸汽压: 0.0±1.0 mmHg at 25°C
• 折射率: 1.616
• 储存条件: 2-8°C，干燥，密封

安全

• 危害码 (欧洲): T+

合成路线

136918-14-4 67843-74-7 ~74% 148857-42-5

文献：Tammana, Rajesh; Vemula, Kiran Kumar; Guruvindapalli, Ramadasu; Yanamandr, Ramesh; Gutta, Madhusudhan Arkivoc, 2012 , vol. 2012, # 6 p. 45 - 56

136918-14-4 67843-74-7 1074-82-4 ~% 148857-42-5

文献：Pharmacia and Upjohn Company Patent: US6362334 B1, 2002 ; Location in patent: Example 4 ;

136918-14-4 51594-55-9 ~82% 161596-47-0 148857-42-5

文献：Pace, Vittorio; Hoyos, Pilar; Fernandez, Maria; Sinisterra, Jose V.; Alcantara, Andres R. Green Chemistry, 2010 , vol. 12, # 8 p. 1380 - 1382

1074-82-4 ~% 148857-42-5

文献：Martinez Lagos, Fernando; Carballeira, Jose D.; Bermudez, Jose L.; Alvarez, Emilio; Sinisterra, Jose V. Tetrahedron Asymmetry, 2004 , vol. 15, # 5 p. 763 - 770

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