10419-79-1

10419-79-1结构式

常用中文名：二乙基(2-乙基氯)磷酸盐
常用英文名：diethyl (2-chloroethyl)phosphonate
CAS号：10419-79-1
分子式：C₆H₁₄ClO₃P
分子量：200.60000
相关类别：化学试剂有机试剂膦酸酯/膦酸盐
发布时间：2018-03-05 08:00:00
更新时间：2024-01-02 16:32:13

中文名	二乙基(2-乙基氯)磷酸盐
英文名	1-chloro-2-diethoxyphosphorylethane
英文别名	Diethyl (2-chloroethyl)phosphonate EINECS 240-718-3 Diethyl 2-chloroethanephosphonate ethyl 2-chloroethylphosphonate

密度	1.14g/cm3
沸点	250.5ºC at 760mmHg
分子式	C₆H₁₄ClO₃P
分子量	200.60000
闪点	98.9ºC
精确质量	200.03700
PSA	45.34000
LogP	2.49130
蒸汽压	0.0342mmHg at 25°C
折射率	1.439-1.442
储存条件	密闭于阴凉干燥环境中
稳定性	遵照规定使用和储存则不会分解。
分子结构	1、摩尔折射率：无可用 2、摩尔体积（cm³/mol）：无可用 3、等张比容（90.2K）：无可用 4、表面张力（dyne/cm）：无可用 5、极化率：无可用
计算化学	1、疏水参数计算参考值（XlogP）：0.8 2、氢键供体数量：0 3、氢键受体数量：3 4、可旋转化学键数量：6 5、拓扑分子极性表面积（TPSA）：35.5 6、重原子数量：11 7、表面电荷：0 8、复杂度：130 9、同位素原子数量：0 10、确定原子立构中心数量：0 11、不确定原子立构中心数量：0 12、确定化学键立构中心数量：0 13、不确定化学键立构中心数量：0 14、共价键单元数量：1
更多	1. 性状：无可用 2. 密度（g/mL,25/4℃）： 1.15 3. 相对蒸汽密度（g/mL,空气=1）：无可用 4. 熔点（ºC）：无可用 5. 沸点（ºC,常压）：92-94 6. 沸点（ºC,5.2kPa）：无可用 7. 折射率：1.439-1.442 8. 闪点（ºC）：98 9. 比旋光度（º）：无可用 10. 自燃点或引燃温度（ºC）：无可用 11. 蒸气压（kPa,25ºC）：无可用 12. 饱和蒸气压（kPa,60ºC）：无可用 13. 燃烧热（KJ/mol）：无可用 14. 临界温度（ºC）：无可用 15. 临界压力（KPa）：无可用 16. 油水（辛醇/水）分配系数的对数值：无可用 17. 爆炸上限（%,V/V）：无可用 18. 爆炸下限（%,V/V）：无可用 19. 溶解性：无可用

Name:	Diethyl (2-Chloroethyl)phosphonate 95% Material Safety Data Sheet
Synonym:	(2-Chloroethyl)phosphonic Acid Diethyl Ester
CAS:	10419-79-1

Section 1 - Chemical Product MSDS Name:Diethyl (2-Chloroethyl)phosphonate 95% Material Safety Data Sheet
Synonym:(2-Chloroethyl)phosphonic Acid Diethyl Ester

Section 2 - COMPOSITION, INFORMATION ON INGREDIENTS

CAS#	Chemical Name	content	EINECS#
10419-79-1	Diethyl (2-Chloroethyl)phosphonate	95%	unlisted

Hazard Symbols: XN
Risk Phrases: 22 36/37/38

Section 3 - HAZARDS IDENTIFICATION

EMERGENCY OVERVIEW
Harmful if swallowed. Irritating to eyes, respiratory system and skin.The toxicological properties of this material have not been fully investigated.
Potential Health Effects
Eye:
Causes eye irritation.
Skin:
Causes skin irritation.
Ingestion:
Harmful if swallowed. Causes gastrointestinal irritation with nausea, vomiting and diarrhea.
Inhalation:
Causes respiratory tract irritation. The toxicological properties of this substance have not been fully investigated.
Chronic:
No information found.

Section 4 - FIRST AID MEASURES
Eyes: Flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical aid.
Skin:
Get medical aid. Flush skin with plenty of water for at least 15 minutes while removing contaminated clothing and shoes. Wash clothing before reuse.
Ingestion:
Never give anything by mouth to an unconscious person. Get medical aid. Do NOT induce vomiting. If conscious and alert, rinse mouth and drink 2-4 cupfuls of milk or water. Wash mouth out with water.
Inhalation:
Remove from exposure and move to fresh air immediately. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get medical aid.
Notes to Physician:
Treat symptomatically and supportively.

Section 5 - FIRE FIGHTING MEASURES
General Information:
As in any fire, wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. During a fire, irritating and highly toxic gases may be generated by thermal decomposition or combustion. Will burn if involved in a fire. Use water spray to keep fire-exposed containers cool. Vapors may be heavier than air. They can spread along the ground and collect in low or confined areas. Containers may explode when heated.
Extinguishing Media:
Use water spray, dry chemical, carbon dioxide, or chemical foam. Use agent most appropriate to extinguish fire. Cool containers with flooding quantities of water until well after fire is out.

Section 6 - ACCIDENTAL RELEASE MEASURES
General Information: Use proper personal protective equipment as indicated in Section 8.
Spills/Leaks:
Absorb spill with inert material (e.g. vermiculite, sand or earth), then place in suitable container. Avoid runoff into storm sewers and ditches which lead to waterways. Clean up spills immediately, observing precautions in the Protective Equipment section. Remove all sources of ignition. Provide ventilation.

Section 7 - HANDLING and STORAGE
Handling:
Wash thoroughly after handling. Use with adequate ventilation. Avoid breathing dust, vapor, mist, or gas. Avoid contact with eyes, skin, and clothing. Keep container tightly closed. Avoid ingestion and inhalation. Wash clothing before reuse.
Storage:
Keep away from sources of ignition. Store in a tightly closed container. Store in a cool, dry, well-ventilated area away from incompatible substances.

Section 8 - EXPOSURE CONTROLS, PERSONAL PROTECTION
Engineering Controls:
Facilities storing or utilizing this material should be equipped with an eyewash facility and a safety shower. Use adequate ventilation to keep airborne concentrations low.
Exposure Limits CAS# 10419-79-1: Personal Protective Equipment Eyes: Wear appropriate protective eyeglasses or chemical safety goggles as described by OSHA's eye and face protection regulations in 29 CFR 1910.133 or European Standard EN166.
Skin:
Wear appropriate protective gloves to prevent skin exposure.
Clothing:
Wear appropriate protective clothing to prevent skin exposure.
Respirators:
A respiratory protection program that meets OSHA's 29 CFR 1910.134 and ANSI Z88.2 requirements or European Standard EN 149 must be followed whenever workplace conditions warrant respirator use.

Section 9 - PHYSICAL AND CHEMICAL PROPERTIES

Physical State: Liquid
Color: colorless
Odor: Not available.
pH: Not available.
Vapor Pressure: Not available.
Viscosity: Not available.
Boiling Point: 92 - 94 deg C @ 4.00mm Hg
Freezing/Melting Point: Not available.
Autoignition Temperature: Not available.
Flash Point: 98 deg C ( 208.40 deg F)
Explosion Limits, lower: Not available.
Explosion Limits, upper: Not available.
Decomposition Temperature:
Solubility in water:
Specific Gravity/Density: 1.1500g/cm3
Molecular Formula: C6H14ClO3P
Molecular Weight: 200.62

Section 10 - STABILITY AND REACTIVITY
Chemical Stability:
Stable at room temperature in closed containers under normal storage and handling conditions.
Conditions to Avoid:
Incompatible materials, excess heat.
Incompatibilities with Other Materials:
Oxidizing agents.
Hazardous Decomposition Products:
Hydrogen chloride, phosphine, carbon monoxide, oxides of phosphorus, irritating and toxic fumes and gases, carbon dioxide.
Hazardous Polymerization: Has not been reported

Section 11 - TOXICOLOGICAL INFORMATION
RTECS#:
CAS# 10419-79-1: SZ7110000 LD50/LC50:
CAS# 10419-79-1: Oral, rabbit: LD50 = 2 gm/kg; Oral, rat: LD50 = 1 gm/kg.
Carcinogenicity:
Diethyl (2-Chloroethyl)phosphonate - Not listed by ACGIH, IARC, or NTP.
Other:
See actual entry in RTECS for complete information.

Section 12 - ECOLOGICAL INFORMATION

Section 13 - DISPOSAL CONSIDERATIONS
Dispose of in a manner consistent with federal, state, and local regulations.

Section 14 - TRANSPORT INFORMATION

IATA
Not regulated as a hazardous material.
IMO
Not regulated as a hazardous material.
RID/ADR
Not regulated as a hazardous material.

Section 15 - REGULATORY INFORMATION

European/International Regulations
European Labeling in Accordance with EC Directives
Hazard Symbols: XN
Risk Phrases:
R 22 Harmful if swallowed.
R 36/37/38 Irritating to eyes, respiratory system
and skin.
Safety Phrases:
S 26 In case of contact with eyes, rinse immediately
with plenty of water and seek medical advice.
S 28A After contact with skin, wash immediately with
plenty of water.
S 37 Wear suitable gloves.
S 37/39 Wear suitable gloves and eye/face
protection.
S 45 In case of accident or if you feel unwell, seek
medical advice immediately (show the label where
possible).
WGK (Water Danger/Protection)
CAS# 10419-79-1: No information available.
Canada
None of the chemicals in this product are listed on the DSL/NDSL list.
CAS# 10419-79-1 is not listed on Canada's Ingredient Disclosure List.
US FEDERAL
TSCA
CAS# 10419-79-1 is not listed on the TSCA inventory.
It is for research and development use only.

SECTION 16 - ADDITIONAL INFORMATION
N/A

毒理学数据:

1 。
试验方法：口服
摄入剂量： 1毫克/千克
测试对象：啮齿动物-鼠
毒性类型：急性
毒性作用： 1.嗜睡（普通抑郁活动）
2.肌肉无力
3.肺，胸部或呼吸-其他变化
2 。
试验方法：口服
摄入剂量： 2毫克/千克
测试对象：啮齿动物-兔
毒性类型：急性
毒性作用： 1.嗜睡（普通抑郁活动）
2.肌肉收缩或痉挛
3.肺，胸部或呼吸-其他变化

生态学数据:

该物质对环境可能有危害，对水体应给予特别注意。

CHEMICAL IDENTIFICATION

RTECS NUMBER :: SZ7110000

CHEMICAL NAME :: Phosphonic acid, (2-chloroethyl)-, diethyl ester

CAS REGISTRY NUMBER :: 10419-79-1

BEILSTEIN REFERENCE NO. :: 1766076

LAST UPDATED :: 199612

DATA ITEMS CITED :: 3

MOLECULAR FORMULA :: C6-H14-Cl-O3-P

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 1 gm/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Behavioral - muscle weakness Lungs, Thorax, or Respiration - other changes

REFERENCE :: GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936- Volume(issue)/page/year: 48(8),79,1983

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 2 gm/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Behavioral - muscle contraction or spasticity Lungs, Thorax, or Respiration - other changes

REFERENCE :: GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936- Volume(issue)/page/year: 48(8),79,1983

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - guinea pig

DOSE/DURATION :: 1450 mg/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Behavioral - muscle contraction or spasticity Lungs, Thorax, or Respiration - other changes

REFERENCE :: GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936- Volume(issue)/page/year: 48(8),79,1983

危害码 (欧洲)	Xn: Harmful;
风险声明 (欧洲)	36/37/38-22
安全声明 (欧洲)	37/39-26
海关编码	2931900090

107-06-2

122-52-1

~62%

10419-79-1

文献：USTAV ORGANICKE CHEMIE A BIOCHEMIE AKADEMIE VED CESKE REPUBLIKY, v.v.i.; JANSA, Petr; HOLY, Antonin; CESNEK, Michal Patent: WO2012/13168 A1, 2012 ; Location in patent: Page/Page column 22-23 ;

107-04-0

122-52-1

~94%

10419-79-1

文献：Fourgeaud, Pierre; Midrier, Camille; Vors, Jean-Pierre; Volle, Jean-Noel; Pirat, Jean-Luc; Virieux, David Tetrahedron, 2010 , vol. 66, # 3 p. 758 - 764

64-17-5

690-12-0

10419-79-1

文献：Bliznyuk,N.K. et al. J. Gen. Chem. USSR (Engl. Transl.), 1967 , vol. 37, p. 1119 - 1122,1061 - 1063

107-06-2

122-52-1

78-38-6

10419-79-1

文献：Jansa, Petr; Holy, Antonin; Dracinsky, Martin; Baszczynski, Ondrej; Cesnek, Michal; Janeba, Zlatko Green Chemistry, 2011 , vol. 13, # 4 p. 882 - 888

18359-24-5

10419-79-1

文献：Kabatschnik; Rossiskaja Izvestiya Akademii Nauk SSSR, Seriya Khimicheskaya, 1948 , p. 99 Chem.Abstr., 1948 , p. 5846

海关编码	2931900090
中文概述	2931900090. 其他有机-无机化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:AB(入境货物通关单,出境货物通关单). 最惠国关税:6.5%. 普通关税:30.0%
Summary	2931900090. other organo-inorganic compounds. VAT:17.0%. Tax rebate rate:13.0%. Supervision conditions:AB(certificate of inspection for goods inward,certificate of inspection for goods outward). MFN tariff:6.5%. General tariff:30.0%

10419-79-1	36305-51-8
22268-66-2	850231-86-6
663199-29-9	157230-68-7
2609-49-6	1068-22-0
149-11-1	17053-09-7