中文名 | 琥珀酸瓦他拉尼 |
---|---|
英文名 | butanedioic acid,N-(4-chlorophenyl)-4-(pyridin-4-ylmethyl)phthalazin-1-amine |
中文别名 | N-(4-氯苯基)-4-(4-吡啶甲基)-1-酞嗪胺琥珀酸盐 |
英文别名 |
N-(4-Chlorophenyl)-4-(4-pyridinylmethyl)-1-phthalazinamine, butanedioate (1:1)
PTK787 1-(4-chloroanilino)-4-(4-pyridylmethyl)phthalazine succinate Succinic acid - N-(4-chlorophenyl)-4-(4-pyridinylmethyl)-1-phthalazinamine (1:1) 1-Phthalazinamine, N-(4-chlorophenyl)-4-(4-pyridinylmethyl)-, butanedioate (1:1) N-(4-Chlorophenyl)-4-(pyridin-4-ylmethyl)phthalazin-1-amine succinate N-(4-Chlorophenyl)-4-(pyridin-4-ylmethyl)phthalazin-1-amine succinate (1:1) (4-Chlorophenyl)[4-(pyridin-4-ylmethyl)-phthalazin-1-yl]ammonium hydrogen succinate N-(4-chlorophenyl)-4-(pyridin-4-ylmethyl)phthalazin-1-amine butanedioate (1:1) (4-Chlorophenyl)[4-(4-pyridylmethyl)-phthalazin-1-yl]ammonium hydrogen succinate Vatalanib T66 CNNJ BMR DG& E1- DT6NJ &&Succinate Vatalanib succinate PTK/ZK |
描述 | Vatalanib (PTK787) succinate 是一种有效的具有口服活性的 VEGFR 抑制剂,对 KDR、Flt-1、Flk、Flt-4、c-Kit、c-Fms 和 PDGFR-β 的 IC50 值分别为 37 nM,77 nM,270 nM,660 nM,730 nM,1400 nM 和 580 nM。 |
---|---|
相关类别 | |
靶点 |
KDR:37 nM (IC50) Flt-1:77 nM (IC50) Flt-4:730 nM (IC50) |
参考文献 |
沸点 | 587.8ºC at 760 mmHg |
---|---|
熔点 | 195ºC |
分子式 | C24H21ClN4O4 |
分子量 | 464.90 |
闪点 | 309.3ºC |
精确质量 | 464.125122 |
PSA | 125.30000 |
LogP | 5.02140 |
蒸汽压 | 8.48E-14mmHg at 25°C |