琥珀酸瓦他拉尼

• 常用名: 琥珀酸瓦他拉尼
• 英文名: Vatalanib succinate
• CAS号: 212142-18-2
• 分子量: 464.90
• 密度: N/A
• 沸点: 587.8ºC at 760 mmHg
• 分子式: C₂₄H₂₁ClN₄O₄
• 熔点: 195ºC
• 闪点: 309.3ºC

琥珀酸瓦他拉尼用途

Vatalanib (PTK787) succinate 是一种有效的具有口服活性的 VEGFR 抑制剂,对 KDR、Flt-1、Flk、Flt-4、c-Kit、c-Fms 和 PDGFR-β 的 IC50 值分别为 37 nM,77 nM,270 nM,660 nM,730 nM,1400 nM 和 580 nM。

琥珀酸瓦他拉尼名称

• 中文名: 琥珀酸瓦他拉尼
• 英文名: butanedioic acid,N-(4-chlorophenyl)-4-(pyridin-4-ylmethyl)phthalazin-1-amine
• 中文别名: N-(4-氯苯基)-4-(4-吡啶甲基)-1-酞嗪胺琥珀酸盐

琥珀酸瓦他拉尼生物活性

• 描述: Vatalanib (PTK787) succinate 是一种有效的具有口服活性的 VEGFR 抑制剂,对 KDR、Flt-1、Flk、Flt-4、c-Kit、c-Fms 和 PDGFR-β 的 IC50 值分别为 37 nM,77 nM,270 nM,660 nM,730 nM,1400 nM 和 580 nM。
• 相关类别:
  研究领域 >> 癌症
  信号通路 >> 蛋白酪氨酸激酶 >> VEGFR
• 靶点实验:

  KDR:37 nM (IC50)

  Flt-1:77 nM (IC50)

  Flt-4:730 nM (IC50)

• 参考文献:

  [1]. J M Wood, et al. PTK787/ZK 222584, a novel and potent inhibitor of vascular endothelial growth factor receptor tyrosine kinases, impairs vascular endothelial growth factor-induced responses and tumor growth after oral administration. Cancer Res. 2000 Apr 15;60(8):2178-89.

琥珀酸瓦他拉尼物理化学性质

• 沸点: 587.8ºC at 760 mmHg
• 熔点: 195ºC
• 分子式: C₂₄H₂₁ClN₄O₄
• 分子量: 464.90
• 闪点: 309.3ºC
• 精确质量: 464.125122
• PSA: 125.30000
• LogP: 5.02140
• InChIKey: LLDWLPRYLVPDTG-UHFFFAOYSA-N
• SMILES: Clc1ccc(Nc2nnc(Cc3ccncc3)c3ccccc23)cc1.O=C(O)CCC(=O)O
• 蒸汽压: 8.48E-14mmHg at 25°C

琥珀酸瓦他拉尼靶点实验

查看更多实验

实验名称：Antiproliferative activity against bFGF-stimulated HUVEC cells assessed as cell growt... 来源：ChEMBL 靶标：HUVEC External Id：CHEMBL5252799

实验名称：Antiproliferative activity against mouse BaF3 cells assessed as cell growth inhibitio... 来源：ChEMBL 靶标：BaF3 External Id：CHEMBL5252796

实验名称：Antiproliferative activity against mouse BaF3 cells expressing Tel-PDGFRbeta assessed... 来源：ChEMBL 靶标：BaF3 External Id：CHEMBL5252795

实验名称：Antiproliferative activity against VEGF-stimulated HUVEC cells assessed as cell growt... 来源：ChEMBL 靶标：HUVEC External Id：CHEMBL5252798

实验名称：Antiproliferative activity against mouse BaF3 cells expressing NPM-ALK assessed as ce... 来源：ChEMBL 靶标：BaF3 External Id：CHEMBL5252797

实验名称：Antiproliferative activity against mouse BaF3 cells expressing Trp-MET assessed as ce... 来源：ChEMBL 靶标：BaF3 External Id：CHEMBL5252792

实验名称：Antiproliferative activity against mouse BaF3 cells expressing KIT D816V mutant asses... 来源：ChEMBL 靶标：BaF3 External Id：CHEMBL5252791

实验名称：Antiproliferative activity against mouse BaF3 cells expressing PTC3-RET assessed as c... 来源：ChEMBL 靶标：BaF3 External Id：CHEMBL5252794

实验名称：Antiproliferative activity against mouse BaF3 cells expressing Tel-FGFR3 assessed as ... 来源：ChEMBL 靶标：BaF3 External Id：CHEMBL5252788

实验名称：Antiproliferative activity against mouse BaF3 cells expressing ERBB2 V659E mutant ass... 来源：ChEMBL 靶标：BaF3 External Id：CHEMBL5252787

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琥珀酸瓦他拉尼英文别名

• N-(4-Chlorophenyl)-4-(4-pyridinylmethyl)-1-phthalazinamine, butanedioate (1:1)
• PTK787
• 1-(4-chloroanilino)-4-(4-pyridylmethyl)phthalazine succinate
• Succinic acid - N-(4-chlorophenyl)-4-(4-pyridinylmethyl)-1-phthalazinamine (1:1)
• 1-Phthalazinamine, N-(4-chlorophenyl)-4-(4-pyridinylmethyl)-, butanedioate (1:1)
• N-(4-Chlorophenyl)-4-(pyridin-4-ylmethyl)phthalazin-1-amine succinate
• N-(4-Chlorophenyl)-4-(pyridin-4-ylmethyl)phthalazin-1-amine succinate (1:1)
• (4-Chlorophenyl)[4-(pyridin-4-ylmethyl)-phthalazin-1-yl]ammonium hydrogen succinate
• N-(4-chlorophenyl)-4-(pyridin-4-ylmethyl)phthalazin-1-amine butanedioate (1:1)
• (4-Chlorophenyl)[4-(4-pyridylmethyl)-phthalazin-1-yl]ammonium hydrogen succinate
• Vatalanib
• T66 CNNJ BMR DG& E1- DT6NJ &&Succinate
• Vatalanib succinate
• PTK/ZK