73334-07-3

• 常用中文名：碘普罗胺
• 常用英文名：iopromide
• CAS号：73334-07-3
• 分子式：C₁₈H₂₄I₃N₃O₈
• 分子量：791.112
• 相关类别： 原料药 诊断用药 影象检查用药
• 发布时间：2018-02-25 08:00:00
• 更新时间：2026-07-01 18:59:07
• Iopromide是用于血管内给药的水溶的低渗透非离子型X射线造影剂。

名称

• 中文名: 碘普罗胺
• 英文名: iopromide
• 中文别名: 伊诺肝素纳; 碘普罗胺/用于系统适用性试验1/A1A; 碘普罗胺对照品; N,N''-双(2,3-二羟丙基)-2,4,6-三碘-5-[(2-甲氧基乙酰基)氨基]-N''-甲基苯基-1,3-甲酰; 碘普罗胺 标准品; 碘普罗恩; 碘普罗胺(异构体混合物); 碘普罗胺用于系统适应性2 标准品; N,N'-双(2,3-二羟丙基)-2,4,6-三碘-5-[(2-甲氧基乙酰基)氨基]-N'-甲基苯基-1,3-甲酰胺; 化合物：Iopromide; 化合物:Iopromide; 碘普罗胺/A1A; 碘普胺; 乙腈中碘普罗胺; N1,N3-双(2,3-二羟丙基)-2,4,6-三碘-5-(2-甲氧基乙酰胺)-N1-甲基间苯二甲酰胺; 碘普罗胺,10 MM DMSO 溶液; 碘普罗胺/用于系统适用性试验2/A1A; 碘普罗胺 优维显 碘普胺 二丙醇胺己酞氨酸; 碘普罗胺Iopromide; 碘普罗胺Iopromid; 碘普罗胺用于系统适应性1 标准品
• 英文别名: N1,N3-bis(2,3-dihydroxypropyl)-2,4,6-triiodo-5-(2-methoxyacetamido)-N1-methylbenzene-1,3-dicboxamide; N,N'-Bis(2,3-dihydroxypropyl)-2,4,6-triiodo-5-[(methoxyacetyl)amino]-N-methylisophthalamide; Iopromide for system suitability 2 CRS; iopromidum; Iopromide CRS; 1,3-Benzenedicboxamide, N1,N3-bis(2,3-dihydroxypropyl)-2,4,6-triiodo-5-[(2-methoxyacetyl)amino]-N1-methyl; IopromideQ: What is Iopromide Q: What is the CAS Number of Iopromide Q: What is the storage condition of Iopromide Q: What e the applications of Iopromide; Ultravist 370; IoproMide SynonyMs: N,N'-Bis(2,3-dihydroxypropyl)-2,4,6-triiodo-5-[(2-Methoxyacetyl)amino]-N'-Methylbenzene-1,3-dicboxaMide; N1,N3-bis(2,3-dihydroxypropyl)-2,4,6-triiodo-5-(2-methoxyethanoylamino)-N3-methyl-benzene-1,3-dicboxamide; IOPROMIDE; Iopromide for system suitability 1 CRS; N,N'-Bis(2,3-dihydroxypropyl)-2,4,6-triiodo-5-[(methoxyacetyl)amino]-N-methyl-1,3-benzenedicboxamide; Iopromide //BP; Iopromide, >=; Iopromide (Mixture of Diastereomers); iopromida; N,N'-bis(2,3-dihydroxypropyl)-2,4,6-triiodo-N-methyl-5-{[(methyloxy)acetyl]amino}benzene-1,3-dicarboxamide; Iopromide 100 μg/ml Water; Ultravist 300; Iopromide（mixture of isomers）; Ioprosamide; Iopromid 100 μg/mL in Acetonitrile; 1,3-Benzenedicboxamide, N,N'-bis(2,3-dihydroxypropyl)-2,4,6-triiodo-5-[(methoxyacetyl)amino]-N-methyl; Iopromide, isomer mixture; Proscope; oproMide; MFCD00867924; 1-N,3-N-bis(2,3-dihydroxypropyl)-2,4,6-triiodo-5-[(2-methoxyacetyl)amino]-3-N-methylbenzene-1,3-dicboxamide; Ultravist; N,N'-bis(2,3-dihydroxypropyl)-2,4,6-triiodo-5-[(méthoxyacétyl)amino]-N-méthylbenzène-1,3-dicarboxamide; N1,N3-Bis(2,3-dihydroxypropyl)-2,4,6-triiodo-5-(2-methoxyacetamido)-N1-methylisophthalamide; 5-Methoxyacetylamino-2,4,6-triiodoisophthalic Acid [(2,3-Dihydroxy-N-methylpropyl)-(2,3-dihydroxypropyl)]diamide; EINECS 277-385-9; shl414c; N,N'-Bis(2,3-dihydroxypropyl)-2,4,6-triiodo-5-[(methoxyacetyl)amino]-N-methyl-1,3-benzenedicarboxamide; N,N'-bis(2,3-dihydroxypropyl)-2,4,6-triiodo-5-[(methoxyacetyl)amino]-N-methylbenzene-1,3-dicarboxamide; UNII:712BAC33MZ; N,N'-Bis(2,3-dihydroxypropyl)-2,4,6-triiodo-5-[(2-methoxyacetyl)amino]-N'-methylbenzene-1,3-dicboxamide; Iopromidum; 1,3-benzenedicboxamide,n,n’-bis(2,3-dihydroxypropyl)-5-((methoxyacetyl)amino; Iopromid; N,N'-Bis(2,3-dihydroxypropyl)-2,4,6-triiod-5-[(methoxyacetyl)amino]-N-methylbenzol-1,3-dicarboxamid; N,N'-diglyceryl-2,4,6-triiodo-5-[(2-methoxyacetyl)amino]-N'-methyl-isophthalamide; Iopromide, isomer mixture in water; magnesium methanide propan-1-ide(1:1:1); N,N'-Bis(2,3-dihydroxypropyl)-2,4,6-triiodo-5-(2-methoxyacetylamino)-N-methylisophthalamide; C14348600 Iopromid; SHL 414C; 6-triiodo-)-n-methyl-4; 1-N,3-N-bis(2,3-dihydroxypropyl)-2,4,6-triiodo-5-[(2-methoxyacetyl)amino]-3-N-methylbenzene-1,3-dicarboxamide; Iopromide in Acetonitrile; Iopromide, 10 mM in DMSO

物化性质

• 密度: 2.2±0.1 g/cm3
• 沸点: 840.9±65.0 °C at 760 mmHg
• 熔点: broad (160ºC transition)
• 分子式: C₁₈H₂₄I₃N₃O₈
• 分子量: 791.112
• 闪点: 462.4±34.3 °C
• 精确质量: 790.869690
• PSA: 168.66000
• LogP: -2.95
• 外观性状: 灰白色至白色粉末
• 蒸汽压: 0.0±3.3 mmHg at 25°C
• 折射率: 1.710
• 储存条件: Hygroscopic, -20?C Freezer, Under Inert Atmosphere
• 稳定性: Hygroscopic

生物活性

• 描述: Iopromide是用于血管内给药的水溶的低渗透非离子型X射线造影剂。
• 相关类别:
  信号通路 >> 其他 >> 其他
  研究领域 >> 心血管疾病
• 体内研究: 尾静脉注射碘普罗胺可诱导造影剂中引起的肾病[1]。在随机对照试验中,iobitridol的全球图像质量和诊断质量与其他低渗造影剂(碘海醇,碘普罗胺,碘帕醇,碘美普尔和异恶唑)或等渗造影剂碘克沙醇在成人或儿童中的差异无统计学差异射线照相成像。大型上市后监测研究证实,iobitridol可产生良好或极好的混浊,是绝大多数患者的有效造影剂。碘比特醇通常具有良好的耐受性,并且具有与其他低渗和等渗对比剂相似的耐受性特征。因此,iobitridol是一种有效的血管内药物,用于诊断成像中的对比度增强[2]。
• 动物实验: 小鼠：雄性C57 / BL6J小鼠随机分为7组：对照组，糖尿病组（D），CIN，糖尿病+ CIN（DC），糖尿病+灯盏花素（DB），CIN +灯盏花素（CIN + B）和糖尿病mellitus + CIN +灯盏花素（DCB）。在建立糖尿病模型后，禁止小鼠饮水一晚，然后在1分钟内通过尾静脉给药以10mL / kg碘普罗胺的剂量注射小鼠。然后用或不用灯盏花素（10mg / kg / d）对小鼠进行胃内治疗4周。除灯盏花素处理组（DB，DCB和CIN + B）之外的其他小鼠组在胃内给予相同体积的磷酸盐缓冲溶液4周。然后通过腹膜内注射水合氯醛处死小鼠[1]。
• 参考文献:

  [1]. Jiang W, et al. Breviscapine attenuatted contrast medium-induced nephropathy via PKC/Akt/MAPK signalling in diabetic mice. Am J Transl Res. 2016 Feb 15;8(2):329-41.

  [2]. McCormack PL, et al. Iobitridol: a review of its use as a contrast medium in diagnostic imaging. Clin Drug Investig. 2013 Feb;33(2):155-66.

毒性和生态

CHEMICAL IDENTIFICATION RTECS NUMBER : CZ2230000 CHEMICAL NAME : 1,3-Benzenedicarboxamide, N,N'-bis(2,3-dihydroxypropyl)-5-((methoxyacetyl)amino )-N-methyl- 2,4,6-triiodo- CAS REGISTRY NUMBER : 73334-07-3 LAST UPDATED : 199612 DATA ITEMS CITED : 3 MOLECULAR FORMULA : C18-H24-I3-N3-O8 MOLECULAR WEIGHT : 791.15 HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 21403 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : ARASA5 Acta Radiologica, Supplementum. (Acta Radiologica, POB 7449, S-10391 Stockholm, Sweden) No.1- 1921- Volume(issue)/page/year: 370,41,1987 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 34 gm/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : AAJNDL AJNR, American Journal of Neuroradiology. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1980- Volume(issue)/page/year: 4,350,1983 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Mammal - dog DOSE/DURATION : >21 gm/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 44,1275,1994

安全

• 符号: GHS09
• 信号词: Warning
• 危害声明: H410
• 警示性声明: P273-P501
• 危害码 (欧洲): N
• 风险声明 (欧洲): 50/53
• 安全声明 (欧洲): 60-61
• 危险品运输编码: NONH for all modes of transport
• RTECS号: CZ2230000
• 海关编码: 2924299090

合成路线

1193076-40-2 ~85% 73334-07-3

文献：LG LIFE SCIENCES LTD. Patent: WO2009/134030 A1, 2009 ; Location in patent: Page/Page column 11 - 12 ;

海关

海关编码	2924299090
中文概述	2924299090. 其他环酰胺（包括环氨基甲酸酯）（包括其衍生物以及他们的盐）. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:30.0%
申报要素	品名, 成分含量, 用途, 包装
Summary	2924299090. other cyclic amides (including cyclic carbamates) and their derivatives; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%