77-22-5

• 常用中文名：卡拉美芬
• 常用英文名：caramiphen
• CAS号：77-22-5
• 分子式：C₁₈H₂₇NO₂
• 分子量：289.41200
• 相关类别： 无机化工 无机盐 金属卤化物及卤酸盐 金属溴化物及盐
• 发布时间：2018-06-07 10:30:31
• 更新时间：2026-08-06 21:46:10

名称

• 中文名: 卡拉美芬
• 英文名: 2-(diethylamino)ethyl 1-phenylcyclopentane-1-carboxylate
• 中文别名: 喷托维林杂质B/A1A; 喷托维林杂质B柠檬酸盐; 卡拉米芬; 喷托维林杂质B 标准品; 2-(二乙氨基)乙基1-苯基环戊烷羧酸酯
• 英文别名: CYCLOPENTANECARBOXYLIC ACID,1-PHENYL-,2-(DIETHYLAMINO)ETHYL ESTER; Pentaphen (pharmaceutical); EINECS 201-013-6; 1-phenyl-cyclopentanecarboxylic acid-(2-diethylamino-ethyl ester); Caramiphen; Pentoxyverine impurity B CRS; 2-(Diethylamino)ethyl 1-phenylcyclopentanecarboxylate; camiphen; Caramiphenum [INN-Latin]; 1-Phenyl-1-cyclopentanecboxylic acid 2-(diethylamino)ethyl; camiphen //BP; Pentoxyverine Impurity B; 1-Phenyl-cyclopentancarbonsaeure-(2-diaethylamino-aethylester); Caramiphene [INN-French]; Pentaphen; Caramifenio [INN-Spanish]; Parpanil; amiphen; 1-Phenyl-cyclopentan-1-carbonsaeure-<2-diethylamino-ethylester>; Pentoxyverine hydrogen citrate Impurity B; 2-(Diethylamino)ethyl 1-phenylcyclopentanecboxylate; 1-(2-Diethylaminoethoxycbonyl)-1-phenylcyclopentane; 1-Phenyl-cyclopentan-carbonsaeure-(1)-<2-diethylamino-ethylester>; 1-phenylcyclopentanecboxylic acid 2-diethylaminoethyl ester; 2-diethylaminoethyl 1-phenylcyclopentane-1-cboxylate; Cyclopentanecboxylic acid, 1-phenyl-, 2-(diethylamino)ethyl ester; 1-Phenyl-1-cyclopentanecboxylic acid 2-(diethylamino)ethyl ester

物化性质

• 密度: 1.038g/cm3
• 沸点: 392.1ºC at 760 mmHg
• 分子式: C₁₈H₂₇NO₂
• 分子量: 289.41200
• 闪点: 124.8ºC
• 精确质量: 289.20400
• PSA: 29.54000
• LogP: 3.38340
• 折射率: 1.523

毒性和生态

CHEMICAL IDENTIFICATION RTECS NUMBER : GY3700000 CHEMICAL NAME : Cyclopentanecarboxylic acid, 1-phenyl-, 2-(diethylamino)ethyl ester CAS REGISTRY NUMBER : 77-22-5 BEILSTEIN REFERENCE NO. : 2144901 LAST UPDATED : 199706 DATA ITEMS CITED : 5 MOLECULAR FORMULA : C18-H27-N-O2 MOLECULAR WEIGHT : 289.46 WISWESSER LINE NOTATION : L5TJ AVO2N2&2 AR HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : LDLo - Lowest published lethal dose ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 80 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : APPNAH Acta Physiologica et Pharmacologica Neerlandica. (Amsterdam, Netherlands) V.1-15, 1950-69. For publisher information, see EJPHAZ. Volume(issue)/page/year: 1,4,1950 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 180 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : BCFAAI Bollettino Chimico Farmaceutico. (Societa Editoriale Farmaceutica, Via Ausonio 12, 20123 Milan, Italy) V.33- 1894- Volume(issue)/page/year: 111,293,1972 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 365 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : HPPAAL Helvetica Physiologia et Pharmacologica Acta. (Basel, Switzerland) V.1-26, 1943-68. Discontinued. Volume(issue)/page/year: 16,277,1958 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Subcutaneous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 570 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : HPPAAL Helvetica Physiologia et Pharmacologica Acta. (Basel, Switzerland) V.1-26, 1943-68. Discontinued. Volume(issue)/page/year: 16,277,1958 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 67 mg/kg TOXIC EFFECTS : Behavioral - convulsions or effect on seizure threshold REFERENCE : SMWOAS Schweizerische Medizinische Wochenschrift. (Schwabe & Co., Steintorst 13, 4010 Basel, Switzerland) V.50- 1920- Volume(issue)/page/year: 76,1282,1946

合成路线

100-37-8 ~% 77-22-5

文献：Tilford; Van Campen; Shelton Journal of the American Chemical Society, 1947 , vol. 69, p. 2902,2904

17380-62-0 100-37-8 ~% 77-22-5

文献：Geigy A.G. Patent: US2404588 , 1944 ; Full Text Show Details Geigy A.G. Patent: CH234452 , 1942 ;

77-55-4 ~% 77-22-5

文献：Mndshojan et al. Doklady Akademii Nauk Armyanskoi SSR, 1958 , vol. 27, p. 93,96, 97 Chem.Abstr., 1959 , p. 18904

77-57-6 ~% 77-22-5

文献：Mndshojan et al. Doklady Akademii Nauk Armyanskoi SSR, 1958 , vol. 27, p. 93,96, 97 Chem.Abstr., 1959 , p. 18904

140-29-4 ~% 77-22-5

文献：Mndshojan et al. Doklady Akademii Nauk Armyanskoi SSR, 1958 , vol. 27, p. 93,96, 97 Chem.Abstr., 1959 , p. 18904

77-55-4 100-35-6 ~% 77-22-5

文献：Geigy A.G. Patent: CH240169 , 1942 ;

109-89-7 ~% 77-22-5

文献：Geigy A.G. Patent: CH242289 , 1942 ;

上下游产品

上游产品  7
100-37-8 17380-62-0 77-55-4 77-57-6
140-29-4 100-35-6 109-89-7
下游产品  0