86060-92-6

• 常用中文名：N-芴甲氧羰基-L-苯丙氨酸五氟苯酯
• 常用英文名：Fmoc-Phe-OPfp
• CAS号：86060-92-6
• 分子式：C₃₀H₂₀F₅NO₄
• 分子量：553.47600
• 相关类别： 生物化工 氨基酸及其衍生物 苯丙氨酸类衍生物
• 发布时间：2018-06-24 15:57:08
• 更新时间：2024-01-07 22:31:26
• Fmoc-Phe OPfp是苯丙氨酸衍生物[1]。

名称

• 中文名: FMOC-L-苯丙氨酸五氟苯酯
• 英文名: (2,3,4,5,6-pentafluorophenyl) (2S)-2-(9H-fluoren-9-ylmethoxycarbonylamino)-3-phenylpropanoate
• 中文别名: N-芴甲氧羰基-L-苯丙氨酸五氟苯酯
• 英文别名: Fmoc-phenylalanine pentafluorophenyl ester; Fmoc-Phe-OPfp; N-(9-Fluorenylmethoxycarbonyl)-L-phenylalanine pentafluorophenyl ester; Fmoc-Phe pentafluorophenyl ester; Fmoc-L-Phe-OPfp; Fmoc-L-phenylalanine pentafluorophenyl ester; Fmoc-D-Phe-OPfp; Fmoc-Phe-OC6F5; MFCD00065669

物化性质

• 密度: 1.399g/cm3
• 沸点: 674.8ºC at 760 mmHg
• 熔点: 149-151 °C(lit.)
• 分子式: C₃₀H₂₀F₅NO₄
• 分子量: 553.47600
• 闪点: 361.9ºC
• 精确质量: 553.13100
• PSA: 64.63000
• LogP: 6.82840
• 外观性状: 白色晶体
• 折射率: 1.588
• 储存条件:

  2-8°C冷藏、密闭、干燥处

• 稳定性:

  按规定使用和贮存的不会分解，避氧化物

• 更多:

  1. 性状：白色粉末

  2. 密度（g/mL25 ºC）：未确定

  3. 相对蒸汽密度（g/mL,空气=1）：未确定

  4. 熔点（ºC）：149-151

  5. 沸点（ºC,常压）：未确定

  6. 沸点（ºC0.35mmHg）：未确定

  7. 折射率：未确定

  8. 闪点（ºF）：未确定

  9. 比旋光度（º）：未确定

  10. 自燃点或引燃温度（ºC）：未确定

  11. 蒸气压（kPa,）：未确定

  12. 饱和蒸气压（kPa,60ºC）：未确定

  13. 燃烧热（KJ/mol）：未确定

  14. 临界温度（ºC）：未确定

  15. 临界压力（KPa）：未确定

  16. 油水（正辛醇/水）分配系数的对数值：未确定

  17. 爆炸上限（%,V/V）：未确定

  18. 爆炸下限（%,V/V）：未确定

  19. 溶解性：未确定

生物活性

• 描述: Fmoc-Phe OPfp是苯丙氨酸衍生物[1]。
• 相关类别:
  研究领域 >> 其他
  信号通路 >> 其他 >> 其他
• 体外研究: 氨基酸和氨基酸衍生物已被商业化用作能量补充剂。它们影响合成代谢激素的分泌、运动期间的燃料供应、压力相关任务期间的精神表现,并防止运动引起的肌肉损伤。它们被认为是有益的能生膳食物质[1]。
• 参考文献:

  [1]. Luckose F, et al. Effects of amino acid derivatives on physical, mental, and physiological activities. Crit Rev Food Sci Nutr. 2015;55(13):1793-938.

MSDS

Name: N-(9-Fluorenylmethoxycarbonyl)-L-Phenylalanine Pentafluorophenyl Material Safety Data Sheet Synonym: None CAS: 86060-92-6 Section 1 - Chemical Product MSDS Name:N-(9-Fluorenylmethoxycarbonyl)-L-Phenylalanine Pentafluorophenyl Material Safety Data Sheet Synonym:None Section 2 - COMPOSITION, INFORMATION ON INGREDIENTS CAS# Chemical Name content EINECS# 86060-92-6 N-(9-Fluorenylmethoxycarbonyl)-L-pheny ca 100 unlisted Hazard Symbols: None Listed. Risk Phrases: None Listed. Section 3 - HAZARDS IDENTIFICATION EMERGENCY OVERVIEW The toxicological properties of this material have not been fully investigated. Potential Health Effects Eye: May cause eye irritation. Skin: May cause skin irritation. Ingestion: May cause irritation of the digestive tract. The toxicological properties of this substance have not been fully investigated. Inhalation: May cause respiratory tract irritation. The toxicological properties of this substance have not been fully investigated. Chronic: No information found. Section 4 - FIRST AID MEASURES Eyes: Flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical aid. Skin: Get medical aid. Flush skin with plenty of water for at least 15 minutes while removing contaminated clothing and shoes. Wash clothing before reuse. Ingestion: Never give anything by mouth to an unconscious person. Get medical aid. Do NOT induce vomiting. If conscious and alert, rinse mouth and drink 2-4 cupfuls of milk or water. Wash mouth out with water. Inhalation: Remove from exposure and move to fresh air immediately. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get medical aid. Notes to Physician: Section 5 - FIRE FIGHTING MEASURES General Information: As in any fire, wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. During a fire, irritating and highly toxic gases may be generated by thermal decomposition or combustion. Extinguishing Media: Use agent most appropriate to extinguish fire. Use water spray, dry chemical, carbon dioxide, or appropriate foam. Section 6 - ACCIDENTAL RELEASE MEASURES General Information: Use proper personal protective equipment as indicated in Section 8. Spills/Leaks: Vacuum or sweep up material and place into a suitable disposal container. Clean up spills immediately, observing precautions in the Protective Equipment section. Avoid generating dusty conditions. Provide ventilation. Section 7 - HANDLING and STORAGE Handling: Wash thoroughly after handling. Use with adequate ventilation. Minimize dust generation and accumulation. Avoid breathing dust, vapor, mist, or gas. Avoid contact with eyes, skin, and clothing. Keep container tightly closed. Avoid ingestion and inhalation. Storage: Store in a tightly closed container. Store in a cool, dry, well-ventilated area away from incompatible substances. Keep refrigerated. (Store below 4C/39F.) Section 8 - EXPOSURE CONTROLS, PERSONAL PROTECTION Engineering Controls: Facilities storing or utilizing this material should be equipped with an eyewash facility and a safety shower. Use adequate ventilation to keep airborne concentrations low. Exposure Limits CAS# 86060-92-6: Personal Protective Equipment Eyes: Wear appropriate protective eyeglasses or chemical safety goggles as described by OSHA's eye and face protection regulations in 29 CFR 1910.133 or European Standard EN166. Skin: Wear appropriate protective gloves to prevent skin exposure. Clothing: Wear appropriate protective clothing to prevent skin exposure. Respirators: A respiratory protection program that meets OSHA's 29 CFR 1910.134 and ANSI Z88.2 requirements or European Standard EN 149 must be followed whenever workplace conditions warrant respirator use. Section 9 - PHYSICAL AND CHEMICAL PROPERTIES Physical State: Powder Color: white Odor: Not available. pH: Not available. Vapor Pressure: Not available. Viscosity: Not available. Boiling Point: Not available. Freezing/Melting Point: 151 - 152 deg C Autoignition Temperature: Not applicable. Flash Point: Not applicable. Explosion Limits, lower: Not available. Explosion Limits, upper: Not available. Decomposition Temperature: Solubility in water: Specific Gravity/Density: Molecular Formula: C30H20F5NO4 Molecular Weight: 553.49 Section 10 - STABILITY AND REACTIVITY Chemical Stability: Stable at room temperature in closed containers under normal storage and handling conditions. Conditions to Avoid: Incompatible materials, dust generation, excess heat. Incompatibilities with Other Materials: Oxidizing agents. Hazardous Decomposition Products: Nitrogen oxides, carbon monoxide, irritating and toxic fumes and gases, carbon dioxide, hydrogen fluoride gas. Hazardous Polymerization: Has not been reported Section 11 - TOXICOLOGICAL INFORMATION RTECS#: CAS# 86060-92-6 unlisted. LD50/LC50: Not available. Carcinogenicity: N-(9-Fluorenylmethoxycarbonyl)-L-phenylalanine pentafluoroph - Not listed by ACGIH, IARC, or NTP. Section 12 - ECOLOGICAL INFORMATION Section 13 - DISPOSAL CONSIDERATIONS Dispose of in a manner consistent with federal, state, and local regulations. Section 14 - TRANSPORT INFORMATION IATA Not regulated as a hazardous material. IMO Not regulated as a hazardous material. RID/ADR Not regulated as a hazardous material. Section 15 - REGULATORY INFORMATION European/International Regulations European Labeling in Accordance with EC Directives Hazard Symbols: Not available. Risk Phrases: Safety Phrases: S 24/25 Avoid contact with skin and eyes. S 28A After contact with skin, wash immediately with plenty of water. S 37 Wear suitable gloves. S 45 In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible). WGK (Water Danger/Protection) CAS# 86060-92-6: No information available. Canada None of the chemicals in this product are listed on the DSL/NDSL list. CAS# 86060-92-6 is not listed on Canada's Ingredient Disclosure List. US FEDERAL TSCA CAS# 86060-92-6 is not listed on the TSCA inventory. It is for research and development use only. SECTION 16 - ADDITIONAL INFORMATION N/A

安全

• 个人防护装备: Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
• 危害码 (欧洲): Xi
• 安全声明 (欧洲): S22-S24/25
• 危险品运输编码: NONH for all modes of transport
• WGK德国: 3

合成路线

771-61-9 103321-57-9 ~88% 86060-92-6

文献：Jacobsen, Mogens Havsteen; Buchardt, Ole; Engdahl, Tom; Holm, Arne Tetrahedron Letters, 1991 , vol. 32, # 43 p. 6199 - 6202

35661-40-6 244633-31-6 ~88% 86060-92-6

文献：Pudhom, Khanitha; Vilaivan, Tirayut Tetrahedron Letters, 1999 , vol. 40, # 32 p. 5939 - 5942

771-61-9 35661-40-6 ~93% 86060-92-6

文献：Kisfaludy, Lajos; Schoen, Istvan Synthesis, 1983 , # 4 p. 325 - 327

14533-84-7 35661-40-6 ~10% 86060-92-6

文献：Green, Michael; Berman, Judd Tetrahedron Letters, 1990 , vol. 31, # 41 p. 5851 - 5852

35661-40-6 96157-57-2 ~93% 86060-92-6

文献：Il'ina, A. V.; Davidovich, Yu. A.; Rogozhin, S. V. Bulletin of the Academy of Sciences of the USSR, Division of Chemical Science (English Translation), 1988 , vol. 37, # 12 p. 2539 - 2541 Izvestiya Akademii Nauk SSSR, Seriya Khimicheskaya, 1988 , # 12 p. 2816 - 2818

771-61-9 ~% 86060-92-6

文献：Bulletin of the Academy of Sciences of the USSR, Division of Chemical Science (English Translation), , vol. 37, # 12 p. 2539 - 2541 Izvestiya Akademii Nauk SSSR, Seriya Khimicheskaya, , # 12 p. 2816 - 2818

35661-40-6 ~% 86060-92-6

文献：Tetrahedron Letters, , vol. 32, # 43 p. 6199 - 6202

63-91-2 ~% 86060-92-6

文献：Synthesis, , # 4 p. 303 - 305

88744-04-1 ~% 86060-92-6

文献：Synthesis, , # 4 p. 303 - 305

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