14252-80-3

• 常用中文名：盐酸布比卡因
• 常用英文名：Bupivacaine hydrochloride
• CAS号：14252-80-3
• 分子式：C₁₈H₂₉ClN₂O
• 分子量：324.889
• 相关类别： 原料药 Anesthetic Agents Local anesthetics
• 发布时间：2018-06-14 19:40:08
• 更新时间：2024-01-02 21:29:08
• 【用途一】
  用于手术局部麻醉和手术后镇痛

名称

• 中文名: 盐酸布比卡因
• 英文名: Bupivacaine Hydrochloride
• 中文别名: 布比卡因盐酸盐; 布比卡因盐酸盐; 1-丁基-2-[N-(2,6-二甲基苯胺甲酰基)]哌啶盐酸盐; 2-哌啶甲酰胺,1-丁基-N-(2,6-二甲基苯基)-,盐酸盐; BUPIVACAINE 盐酸盐
• 英文别名: Bupivacaine hydrochloride; Sensorcaine; Marcaine; bupivacaine HCl; 1-Butyl-N-(2,6-dimethylphenyl)piperidin-2-carboxamidhydrochlorid; MFCD00941462; Win 11318 HCl; UNII:AKA908P8J1; 1-butyl-N-(2,6-diméthylphényl)pipéridine-2-carboxamide chlorhydrate; bupivacaine monohydrochloride; 1-butyl-N-(2,6-dimethylphenyl)piperidine-2-carboxamide hydrochloride; 1-Butyl-N-(2,6-dimethylphenyl)-2-piperidinecarboxamide hydrochloride (1:1); EINECS 241-917-8; 1-Butyl-N-(2,6-dimethylphenyl)piperidine-2-carboxamide hydrochloride (1:1); 2-Piperidinecarboxamide, 1-butyl-N-(2,6-dimethylphenyl)-, hydrochloride (1:1)

物化性质

• 沸点: 423.4ºC at 760 mmHg
• 熔点: 249-251ºC
• 分子式: C₁₈H₂₉ClN₂O
• 分子量: 324.889
• 闪点: 209.9ºC
• 精确质量: 324.196838
• PSA: 32.34000
• LogP: 4.70940
• 外观性状: 白色固体
• 蒸汽压: 2.24E-07mmHg at 25°C
• 储存条件: 库房通风低温干燥,与食品原料类分开存放

毒性和生态

CHEMICAL IDENTIFICATION RTECS NUMBER : TK6125000 CHEMICAL NAME : 2',6'-Pipecoloxylidide, 1-butyl-, hydrochloride, (+-)- CAS REGISTRY NUMBER : 14252-80-3 LAST UPDATED : 199707 DATA ITEMS CITED : 11 MOLECULAR FORMULA : C18-H28-N2-O.Cl-H MOLECULAR WEIGHT : 324.94 WISWESSER LINE NOTATION : T6NTJ A4 BVMR B1 F1 &GH HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Subcutaneous SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 43 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898- Volume(issue)/page/year: 200,359,1972 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 6 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898- Volume(issue)/page/year: 200,359,1972 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 58700 ug/kg TOXIC EFFECTS : Behavioral - anticonvulsant Behavioral - somnolence (general depressed activity) REFERENCE : AACRAT Anesthesia and Analgesia (New York). (Elsevier Science Pub. Co., Inc., 52 Vanderbilt Ave., New York, NY 10017) V.36- 1957- Volume(issue)/page/year: 60,385,1981 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Subcutaneous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 59 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898- Volume(issue)/page/year: 200,359,1972 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 6100 ug/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : ANPRBG Anesthesia Progress. (Elsevier Science Publishing Co.,Inc., 655 Avenue of the Americas, New York, NY 10010) V.13- 1966- Volume(issue)/page/year: 36,79,1989 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intramuscular SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 22753 ug/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : DDREDK Drug Development Research. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.1- 1981- Volume(issue)/page/year: 21,277,1990 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rabbit DOSE/DURATION : 18 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898- Volume(issue)/page/year: 200,359,1972 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - rabbit DOSE/DURATION : 3400 ug/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898- Volume(issue)/page/year: 200,359,1972 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Parenteral SPECIES OBSERVED : Rodent - rabbit DOSE/DURATION : 48 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898- Volume(issue)/page/year: 200,359,1972 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intratracheal SPECIES OBSERVED : Rodent - rabbit DOSE/DURATION : 11 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898- Volume(issue)/page/year: 200,359,1972 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - guinea pig DOSE/DURATION : 50 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: 6,680,1982

安全

• 危害码 (欧洲): T+:Verytoxic;
• 风险声明 (欧洲): R26/27/28
• 安全声明 (欧洲): S22-S36/37/39-S45
• 危险品运输编码: UN 2811
• WGK德国: 3
• RTECS号: TK6125000
• 包装等级: III
• 危险类别: 6.1(b)
• 海关编码: 2942000000

合成路线

14252-80-3 ~94% 14252-80-3

文献：BRIDGE PHARMA, INC. Patent: WO2008/88756 A1, 2008 ; Location in patent: Page/Page column 30-31 ;

27262-45-9 ~97% 14252-80-3

文献：Langston, Marianne; Dyer, Ulrich C.; Frampton, Graham A.C.; Hutton, Gordon; Lock, Christopher J.; Skead, Benjamin M.; Woods, Martin; Zavareh, Hooshang S. Organic Process Research and Development, 2000 , vol. 4, # 6 p. 530 - 533

109-65-9 ~% 14252-80-3

文献：Acta Chemica Scandinavica (1947-1973), , vol. 11, p. 1183,1184

上下游产品

上游产品  3
14252-80-3 27262-45-9 109-65-9
下游产品  1
14252-80-3

海关

海关编码	2942000000