531-44-2

• 常用中文名：东莨菪甙； 东莨菪苷
• 常用英文名：scopolin
• CAS号：531-44-2
• 分子式：C₁₆H₁₈O₉
• 分子量：354.309
• 相关类别： 天然产物 香豆素
• 发布时间：2018-04-29 08:00:00
• 更新时间：2026-07-01 12:11:13
• Scopolin 是一种从拟南芥 (Arabidopsis) 根中分离出来的香豆素。Scopolin 通过激活SIRT1 介导的信号级联反应减轻了肝脂肪变性。

名称

• 中文名: 东莨菪苷
• 英文名: scopolin
• 中文别名: 东莨菪苷(标准品); 东莨菪苷/HPLC; 10-甲氧基铁屎米酮; 东莨菪苷对照品; 东莨菪素 β-D-葡萄糖苷; 东莨菪苷Scopolin; 东莨菪苷,10 MM DMSO 溶液; 东良菪苷; 东莨菪甙
• 英文别名: 7-(beta-D-Glucopyranosyloxy)-6-methoxy-2H-1-benzopyran-2-one; Scopolin; steatosis,Inhibitor,coumin,abidopsis,thaliana,Sirtuin,Scopolin,hatic,inhibit; 7-(β-D-glucopyranosoyloxy)-6-methoxy-2H-1-benzopyran-2-one; 6-Methoxy-7-(beta-D-glucopyranosyloxy)coumin; 7-(b-D-Glucopyranosyloxy)-6-methoxy-2H-1-benzopyran-2-one; 6-Methoxy-2-oxo-2H-chromen-7-yl β-D-glucopyranoside; Scopolin, min; Murrayin; CPD-678; 6-Methoxycoumin 7-O-beta-D-glucoside; Scopoletin 7-glucoside; D-678; 7β-D-Glucopyranosyloxy-6-methoxycoumarin; Scopolin-RM; 2H-1-Benzopyran-2-one, 7-(β-D-glucopyranosyloxy)-6-methoxy; 7-(beta-D-Glucopyranosyloxy)-6-methoxycoumin; Scopoletin β-D-glucoside; Scopoletin glucoside; scopoletin-β-D-galactoside; SCOPOLIN; 5Mg; 6-methoxy-7-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxychromen-2-one; Scopoletin 7-O-Glucoside; LQVTDSGLYRCVIYHPP TFA; 2'-β-D-glucosyl scopolin; Scopoloside; GSK-690 HCl; Scopolin (8CI); Scopoline; FM-381 HCl; Scopolin, 10 mM in DMSO; Ethyl Acetate Impurity

物化性质

• 密度: 1.6±0.1 g/cm3
• 沸点: 650.2±55.0 °C at 760 mmHg
• 熔点: 217ºC
• 分子式: C₁₆H₁₈O₉
• 分子量: 354.309
• 闪点: 241.5±25.0 °C
• 精确质量: 354.095093
• PSA: 138.82000
• LogP: -1.87
• 蒸汽压: 0.0±2.0 mmHg at 25°C
• 折射率: 1.639
• 储存条件: 室温

生物活性

• 描述: Scopolin 是一种从拟南芥 (Arabidopsis) 根中分离出来的香豆素。Scopolin 通过激活SIRT1 介导的信号级联反应减轻了肝脂肪变性。
• 相关类别:
  信号通路 >> 表观遗传学 >> 抗衰老酶
  信号通路 >> 细胞周期/DNA损伤 >> 抗衰老酶
  研究领域 >> 代谢疾病
• 靶点:

  SIRT1

• 参考文献:

  [1]. Siwinska J, et al. Identification of QTLs affecting scopolin and scopoletin biosynthesis in Arabidopsisthaliana. BMC Plant Biol. 2014 Oct 18;14:280.

  [2]. Yoo A, et al. Scopolin ameliorates high-fat diet induced hepatic steatosis in mice: potential involvement of SIRT1-mediated signaling cascades in the liver. Sci Rep. 2017 May 22;7(1):2251.

合成路线

85011-57-0 ~% 1135-24-6 531-44-2

文献：Chemistry of Natural Compounds, , vol. 18, # 6 p. 654 - 657 Khimiya Prirodnykh Soedinenii, , vol. 18, # 6 p. 691 - 695

98296-08-3 ~% 73-34-7 531-44-2

文献：Chemistry of Natural Compounds, , vol. 16, # 2 p. 125 - 128 Khimiya Prirodnykh Soedinenii, , vol. 16, # 2 p. 168 - 172

92-61-5 5328-37-0 ~% 531-44-2

文献：Angewandte Chemie - International Edition, , vol. 45, # 21 p. 3534 - 3538

1207857-19-9 ~% 531-44-2

文献：Song, Shuang; Li, Yixiu; Feng, Ziming; Jiang, Jianshuang; Zhang, Peicheng Journal of Natural Products, 2010 , vol. 73, # 2 p. 177 - 184

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