586379-66-0

• 常用中文名：3-溴-4-(2,4-二氟苄氧基)-1-[5-[(甲基氨基)羰基]-2-甲基苯基]-6-甲基吡啶-2(1H)-酮
• 常用英文名：PH-797804
• CAS号：586379-66-0
• 分子式：C₂₂H₁₉BrF₂N₂O₃
• 分子量：477.299
• 相关类别： 生物化工 抑制剂 丝裂原活化蛋白激酶(MAPK) p38 MAPK 抑制剂
• 发布时间：2018-12-21 13:12:46
• 更新时间：2026-07-09 12:17:54

名称

• 中文名: 3-溴-4-(2,4-二氟苄氧基)-1-[5-[(甲基氨基)羰基]-2-甲基苯基]-6-甲基吡啶-2(1H)-酮
• 英文名: ph 797804
• 中文别名: 3-(3-溴-4-((2,4-二氟苄基)氧基)-6-甲基-2-氧代吡啶-1(2H)-基)-N,4-二甲基苯甲酰胺; PH-797804,ATP竞争性P38Α抑制剂; PH-797804 10mM * 1mL in DMSO试剂; PH-797804 5mg试剂; 依普黄酮
• 英文别名: PH-797804 ，S2726; 3-Bromo-4-[(2,4-difluorobenzyl)oxy]-1-[5-[(methylamino)carbonyl]-2-methylphenyl]-6-methylpyridin-2(1H)-one; PH-797804 PH797804 MAPK Inhibitor; 3-(3-Bromo-4-((2,4-difluorobenzyl)oxy)-6-methyl-2-oxopyridin-1(2H)-yl)-N,4-dimethylbenzamide; PH 797804 //BP; PH 797804, (±)- - rac-PH 797804 | rac-PH; PH-797804, 10 mM in DMSO; PH-797804, >=; 3-[3-bromo-4-[(2,4-difluorophenyl)methoxy]-6-methyl-2-oxopyridin-1-yl]-N,4-dimethylbenzamide; PH 797804;PH; PH 797804; 3-(4-(2,4-difluorobenzyloxy)-3-bromo-6-methyl-2-oxopyridin-1(2H)-yl)-N,4-dimethylbenzamide; 3-{3-Bromo-4-[(2,4-difluorobenzyl)oxy]-6-methyl-2-oxo-1(2H)-pyridinyl}-N,4-dimethylbenzamide

物化性质

• 密度: 1.5±0.1 g/cm3
• 沸点: 593.2±50.0 °C at 760 mmHg
• 分子式: C₂₂H₁₉BrF₂N₂O₃
• 分子量: 477.299
• 闪点: 312.6±30.1 °C
• 精确质量: 476.054718
• PSA: 60.33000
• LogP: 3.24
• 外观性状: 固体
• 蒸汽压: 0.0±1.7 mmHg at 25°C
• 折射率: 1.629
• 储存条件: -20℃

生物活性

• 相关类别:
  信号通路 >> MAPK/ERK信号通路 >> p38 MAPK
  研究领域 >> 炎症/免疫
• 参考文献:

  [1]. Hope HR, et al. Anti-inflammatory properties of a novel N-phenyl pyridinone inhibitor of p38 mitogen-activated protein kinase: preclinical-to-clinical translation. J Pharmacol Exp Ther, 2009, 331(3), 882-895.

  [2]. Xing L, et al. Structural bioinformatics-based prediction of exceptional selectivity of p38 MAP kinase inhibitor PH-797804. Biochemistry, 2009, 48(27), 6402-6411.

安全

• 海关编码: 2933399090

海关

海关编码	2933399090
中文概述	2933399090. 其他结构含非稠合吡啶环的化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%
申报要素	品名, 成分含量, 用途, 乌洛托品请注明外观, 6－己内酰胺请注明外观, 签约日期
Summary	2933399090. other compounds containing an unfused pyridine ring (whether or not hydrogenated) in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%