444912-51-0

• 常用中文名：(R)-AM1241
• 常用英文名：(R)-AM1241
• CAS号：444912-51-0
• 分子式：C₂₂H₂₂IN₃O₃
• 分子量：503.333
• 发布时间：2016-02-15 05:17:53
• 更新时间：2024-01-09 22:53:16
• (R)-AM1241 acts as an agonist at human CB2 receptors but an inverse agonist at rat and mouse CB2 receptors. Similar to the racemate AM1241, (R)-AM1241 produces antinociception to thermal pain but not mechanical pain in rats. The pain-reducing effect of (R)-AM1241 is blocked by the CB2-specific inhibitor SR 144528 but not by either the CB1-selective inhibitor rimonabant or the opioid receptor blocker naloxone.

名称

• 英文名: (r)-am1241
• 英文别名: (2-iodo-5-nitrophenyl){1-[(1-methylpiperidin-2-yl)methyl]-1H-indol-3-yl}methanone; Methanone, (2-iodo-5-nitrophenyl)[1-[(1-methyl-2-piperidinyl)methyl]-1H-indol-3-yl]-; (2-Iodo-5-nitrophenyl){1-[(1-methyl-2-piperidinyl)methyl]-1H-indol-3-yl}methanone; UNII:DLM851L3RD

物化性质

• 密度: 1.6±0.1 g/cm3
• 沸点: 630.7±55.0 °C at 760 mmHg
• 分子式: C₂₂H₂₂IN₃O₃
• 分子量: 503.333
• 闪点: 335.2±31.5 °C
• 精确质量: 503.070587
• PSA: 71.06000
• LogP: 4.85
• 蒸汽压: 0.0±1.8 mmHg at 25°C
• 折射率: 1.696