444912-51-0
444912-51-0 structure
- Name: (R)-AM1241
- Chemical Name: (r)-am1241
- CAS Number: 444912-51-0
- Molecular Formula: C22H22IN3O3
- Molecular Weight: 503.333
- Create Date: 2016-02-15 05:17:53
- Modify Date: 2024-01-09 22:53:16
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(R)-AM1241 acts as an agonist at human CB2 receptors but an inverse agonist at rat and mouse CB2 receptors. Similar to the racemate AM1241, (R)-AM1241 produces antinociception to thermal pain but not mechanical pain in rats. The pain-reducing effect of (R)-AM1241 is blocked by the CB2-specific inhibitor SR 144528 but not by either the CB1-selective inhibitor rimonabant or the opioid receptor blocker naloxone.
| Name | (r)-am1241 |
|---|---|
| Synonyms |
(2-iodo-5-nitrophenyl){1-[(1-methylpiperidin-2-yl)methyl]-1H-indol-3-yl}methanone
Methanone, (2-iodo-5-nitrophenyl)[1-[(1-methyl-2-piperidinyl)methyl]-1H-indol-3-yl]- (2-Iodo-5-nitrophenyl){1-[(1-methyl-2-piperidinyl)methyl]-1H-indol-3-yl}methanone UNII:DLM851L3RD |
| Density | 1.6±0.1 g/cm3 |
|---|---|
| Boiling Point | 630.7±55.0 °C at 760 mmHg |
| Molecular Formula | C22H22IN3O3 |
| Molecular Weight | 503.333 |
| Flash Point | 335.2±31.5 °C |
| Exact Mass | 503.070587 |
| PSA | 71.06000 |
| LogP | 4.85 |
| Vapour Pressure | 0.0±1.8 mmHg at 25°C |
| Index of Refraction | 1.696 |