1101854-58-3

• 常用中文名：JZL 184
• 常用英文名：JZL184
• CAS号：1101854-58-3
• 分子式：C₂₇H₂₄N₂O₉
• 分子量：520.487
• 相关类别： 信号通路 代谢酶/蛋白酶 MAGL
• 发布时间：2017-03-24 19:28:49
• 更新时间：2026-06-30 21:54:53
• JZL 184是MAGL的有效选择性抑制剂,IC50值为8nM,对FAAH的IC50值为4uM。

名称

• 中文名: JZL 184
• 英文名: (4-nitrophenyl) 4-[bis(1,3-benzodioxol-5-yl)-hydroxymethyl]piperidine-1-carboxylate
• 中文别名: 4-(双(苯并[D][1,3]DIOXOL-5-基)(羟基)甲基)哌啶-1-羧酸-4-硝基苯酯; JZL 184试剂; JZL-184,MONOACYLGLYCEROL LIPASE (MAGL)抑制剂; 4-(双(苯并[d][1,3]二氧戊环-5-基)(羟基)甲基)哌啶-1-羧酸-4-硝基苯酯
• 英文别名: 4-[Bis(1,3-benzodioxol-5-yl)hydroxymethyl]-1-piperidinecboxylic acid 4-nitrophenyl ester; 4-Nitrophenyl 4-[bis(1,3-benzodioxol-5-yl)(hydroxy)methyl]-1-piperidinecarboxylate; MAGL Inhibitor III, JZL184 - - Calbiochem; 1-Piperidinecboxylic acid, 4-[bis(1,3-benzodioxol-5-yl)hydroxymethyl]-, 4-nitrophenyl ester; (4-nitrophenyl) 4-[bis(1,3-benzodioxol-5-yl)-hydroxymethyl]piperidine-1-cboxylate; 1-Piperidinecarboxylic acid, 4-[bis(1,3-benzodioxol-5-yl)hydroxymethyl]-, 4-nitrophenyl ester; JZL-184; JZL; JZL184 (with inorganics); 1-Piperidinecboxylicacid,4-[bis(1,3-benzodioxol-5-yl)hydroxymethyl]-,4-nitrophenylester; 4-Nitrophenyl 4-(bis(benzo[d][1,3]dioxol-5-yl)(hydroxy)methyl)piperidine-1-cboxylate; 4-[Bis(1,3-benzodioxol-5-yl)hydroxymethyl]-1-piperidinecboxylic acid 4-nitrophenyl ester JZL; JZL 184, 10 mM in DMSO; 4-Nitrophenyl 4-[bis(1,3-benzodioxol-5-yl)(hydroxy)Methyl]-1-piperidinecboxylate; JZL 184 JZL184 JZL-184 (4-Nitrophenyl) 4-[bis(1,3-benzodioxol-5-yl)-hydroxymethyl]piperidine-1-cboxylate; unii-7mz1i2j68a; JZL 184; JZL-184, monoacylglycerol lipase (MAGL) inhibitor; 4-[Bis(benzo[d][1,3]dioxol-5-yl)hydroxymethyl]-1-piperidinecboxylic acid 4-nitrophenyl ester; jzl184; 4-nitrophenyl 4-[bis(2H-1,3-benzodioxol-5-yl)(hydroxy)methyl]piperidine-1-cboxylate; JZL 184 JZL184 JZL-184

物化性质

• 密度: 1.5±0.1 g/cm3
• 沸点: 706.4±60.0 °C at 760 mmHg
• 分子式: C₂₇H₂₄N₂O₉
• 分子量: 520.487
• 闪点: 381.0±32.9 °C
• 精确质量: 520.148193
• PSA: 132.51000
• LogP: 5.25
• 外观性状: 粉末
• 蒸汽压: 0.0±2.4 mmHg at 25°C
• 折射率: 1.661
• 储存条件: -20℃

生物活性

• 描述: JZL 184是MAGL的有效选择性抑制剂,IC50值为8nM,对FAAH的IC50值为4uM。
• 相关类别:
  信号通路 >> 代谢酶/蛋白酶 >> MAGL
  研究领域 >> 神经疾病
• 参考文献:

  [1]. Long JZ, et al. Selective blockade of 2-arachidonoylglycerol hydrolysis produces cannabinoid behavioral effects. Nat Chem Biol. 2009 Jan;5(1):37-44.

  [2]. Pan B, et al. Blockade of 2-arachidonoylglycerol hydrolysis by selective monoacylglycerol lipase inhibitor 4-nitrophenyl 4-(dibenzo[d][1,3]dioxol-5-yl(hydroxy)methyl)piperidine-1-carboxylate (JZL184) Enhances retrograde endocannabinoid signaling. J Pharma

  [3]. Schlosburg JE, et al. Prolonged monoacylglycerol lipase blockade causes equivalent cannabinoid receptor type 1 receptor-mediated adaptations in fatty acid amide hydrolase wild-type and knockout mice. J Pharmacol Exp Ther. 2014 Aug;350(2):196-204.