JZL 184

• 常用名: JZL 184
• 英文名: JZL184
• CAS号: 1101854-58-3
• 分子量: 520.487
• 密度: 1.5±0.1 g/cm3
• 沸点: 706.4±60.0 °C at 760 mmHg
• 分子式: C₂₇H₂₄N₂O₉
• 熔点: N/A
• 闪点: 381.0±32.9 °C

JZL 184用途

JZL 184是MAGL的有效选择性抑制剂,IC50值为8nM,对FAAH的IC50值为4uM。

JZL 184名称

• 中文名: JZL 184
• 英文名: (4-nitrophenyl) 4-[bis(1,3-benzodioxol-5-yl)-hydroxymethyl]piperidine-1-carboxylate

JZL 184生物活性

• 描述: JZL 184是MAGL的有效选择性抑制剂,IC50值为8nM,对FAAH的IC50值为4uM。
• 相关类别:
  信号通路 >> 代谢酶/蛋白酶 >> MAGL
  研究领域 >> 神经疾病
• 参考文献:

  [1]. Long JZ, et al. Selective blockade of 2-arachidonoylglycerol hydrolysis produces cannabinoid behavioral effects. Nat Chem Biol. 2009 Jan;5(1):37-44.

  [2]. Pan B, et al. Blockade of 2-arachidonoylglycerol hydrolysis by selective monoacylglycerol lipase inhibitor 4-nitrophenyl 4-(dibenzo[d][1,3]dioxol-5-yl(hydroxy)methyl)piperidine-1-carboxylate (JZL184) Enhances retrograde endocannabinoid signaling. J Pharma

  [3]. Schlosburg JE, et al. Prolonged monoacylglycerol lipase blockade causes equivalent cannabinoid receptor type 1 receptor-mediated adaptations in fatty acid amide hydrolase wild-type and knockout mice. J Pharmacol Exp Ther. 2014 Aug;350(2):196-204.

JZL 184物理化学性质

• 密度: 1.5±0.1 g/cm3
• 沸点: 706.4±60.0 °C at 760 mmHg
• 分子式: C₂₇H₂₄N₂O₉
• 分子量: 520.487
• 闪点: 381.0±32.9 °C
• 精确质量: 520.148193
• PSA: 132.51000
• LogP: 5.25
• InChIKey: SEGYOKHGGFKMCX-UHFFFAOYSA-N
• SMILES: O=C(Oc1ccc([N+](=O)[O-])cc1)N1CCC(C(O)(c2ccc3c(c2)OCO3)c2ccc3c(c2)OCO3)CC1
• 外观性状: 粉末
• 蒸汽压: 0.0±2.4 mmHg at 25°C
• 折射率: 1.661
• 储存条件: -20℃

JZL 184靶点实验

查看更多实验

实验名称：Inhibition of PREPL in C57B1/6J mouse brain membrane at 16 mg/kg, ip after 4 hrs by c... 来源：ChEMBL 靶标：Mus musculus External Id：CHEMBL1227701

实验名称：Inhibition of ABHD12 in C57B1/6J mouse brain membrane at 16 mg/kg, ip after 4 hrs by ... 来源：ChEMBL 靶标：Mus musculus External Id：CHEMBL1227700

实验名称：Inhibition of FAS in C57B1/6J mouse brain membrane at 16 mg/kg, ip after 4 hrs by com... 来源：ChEMBL 靶标：Mus musculus External Id：CHEMBL1227699

实验名称：Primary qHTS assay for inhibitors of alpha-synuclein gene (SNCA) expression 来源：NCGC External Id：SNCA-p-activity-luciferase

实验名称：Inhibition of AADACL1 in C57B1/6J mouse brain membrane at 16 mg/kg, ip after 4 hrs by... 来源：ChEMBL 靶标：Mus musculus External Id：CHEMBL1227698

实验名称：Inhibition of FAAH in C57B1/6J mouse brain membrane at 16 mg/kg, ip after 4 hrs by co... 来源：ChEMBL 靶标：Mus musculus External Id：CHEMBL1227697

实验名称：Inhibition of MAGL in C57B1/6J mouse brain membrane at 16 mg/kg, ip after 4 hrs by co... 来源：ChEMBL 靶标：Mus musculus External Id：CHEMBL1227696

实验名称：Inhibition of FAAH-mediated [3H]AEA accumulation in rat RBL2H3 cells membrane by liqu... 来源：ChEMBL 靶标：Fatty-acid amide hydrolase 1 External Id：CHEMBL1065623

实验名称：Inhibition of FAAH in C57B1/6J mouse brain membrane assessed as residual 2-AG hydroly... 来源：ChEMBL 靶标：Mus musculus External Id：CHEMBL1227695

实验名称：Inhibition of FAAH in C57B1/6J mouse brain membrane at 16 mg/kg, ip after 4 hrs by co... 来源：ChEMBL 靶标：Mus musculus External Id：CHEMBL1227694

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JZL 184英文别名

• 4-Nitrophenyl 4-[bis(1,3-benzodioxol-5-yl)(hydroxy)methyl]-1-piperidinecarboxylate
• unii-7mz1i2j68a
• 1-Piperidinecarboxylic acid, 4-[bis(1,3-benzodioxol-5-yl)hydroxymethyl]-, 4-nitrophenyl ester
• jzl184
• JZL 184