2764-03-6

• 常用中文名：亚油酰甘氨酸
• 常用英文名：N-[(9Z,12Z)-9,12-Octadecadienoyl]glycine
• CAS号：2764-03-6
• 分子式：C₂₀H₃₅NO₃
• 分子量：337.497
• 发布时间：2017-06-23 06:59:55
• 更新时间：2024-01-14 01:12:47
• 亚油酸甘氨酸是一种改性多不饱和脂肪酸。亚油酸甘氨酸对爪蟾卵母细胞中表达的人KCNQ1/KCNE1(hKCNQ1/hKCNE1)通道具有激活作用[1]。

名称

• 中文名: 亚油酰甘氨酸
• 英文名: Linoleoyl Glycine
• 英文别名: Glycine-linoleamide; Glycine, N-[(9Z,12Z)-1-oxo-9,12-octadecadien-1-yl]-; N-[(9Z,12Z)-9,12-Octadecadienoyl]glycine; N-linoleoyl glycine; N-[(9Z,12Z)-octadeca-9,12-dienoyl]glycine; linoleyl glycine; Linoleoyl-glycin

物化性质

• 密度: 1.0±0.1 g/cm3
• 沸点: 530.7±43.0 °C at 760 mmHg
• 分子式: C₂₀H₃₅NO₃
• 分子量: 337.497
• 闪点: 274.8±28.2 °C
• 精确质量: 337.261688
• PSA: 66.40000
• LogP: 6.05
• 蒸汽压: 0.0±3.0 mmHg at 25°C
• 折射率: 1.489
• 储存条件: -20°C

生物活性

• 描述: 亚油酸甘氨酸是一种改性多不饱和脂肪酸。亚油酸甘氨酸对爪蟾卵母细胞中表达的人KCNQ1/KCNE1(hKCNQ1/hKCNE1)通道具有激活作用[1]。
• 相关类别:
  研究领域 >> 神经疾病
  信号通路 >> 跨膜转运 >> 钾通道
• 参考文献:

  [1]. Skarsfeldt MA, et al. Polyunsaturated fatty acid-derived IKs channel activators shorten the QT interval ex-vivo and in-vivo. Acta Physiol (Oxf). 2020;229(4):e13471.

毒性和生态

CHEMICAL IDENTIFICATION RTECS NUMBER : MC0596320 CHEMICAL NAME : Glycine, N-linoleoyl- CAS REGISTRY NUMBER : 2764-03-6 LAST UPDATED : 199612 DATA ITEMS CITED : 4 MOLECULAR FORMULA : C20-H35-N-O3 MOLECULAR WEIGHT : 337.56 HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : LDLo - Lowest published lethal dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 250 mg/kg TOXIC EFFECTS : Behavioral - somnolence (general depressed activity) Behavioral - muscle weakness REFERENCE : APFRAD Annales Pharmaceutiques Francaises. (SPPIF, B.P.22, F-41353 Vineuil, France) V.1- 1943- Volume(issue)/page/year: 44,145,1986 TYPE OF TEST : LDLo - Lowest published lethal dose ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 250 mg/kg TOXIC EFFECTS : Behavioral - somnolence (general depressed activity) Behavioral - muscle weakness REFERENCE : APFRAD Annales Pharmaceutiques Francaises. (SPPIF, B.P.22, F-41353 Vineuil, France) V.1- 1943- Volume(issue)/page/year: 44,145,1986 TYPE OF TEST : LDLo - Lowest published lethal dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 250 mg/kg TOXIC EFFECTS : Behavioral - somnolence (general depressed activity) Behavioral - muscle weakness REFERENCE : APFRAD Annales Pharmaceutiques Francaises. (SPPIF, B.P.22, F-41353 Vineuil, France) V.1- 1943- Volume(issue)/page/year: 44,145,1986 TYPE OF TEST : LDLo - Lowest published lethal dose ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 250 mg/kg TOXIC EFFECTS : Behavioral - somnolence (general depressed activity) Behavioral - muscle weakness REFERENCE : APFRAD Annales Pharmaceutiques Francaises. (SPPIF, B.P.22, F-41353 Vineuil, France) V.1- 1943- Volume(issue)/page/year: 44,145,1986

安全

• 海关编码: 2924199090

合成路线

60-33-3 56-40-6 ~% 2764-03-6

文献：Dang, Hung The; Kang, Gyeoung Jin; Yoo, Eun Sook; Hong, Jongki; Choi, Jae Sue; Kim, Hyung Sik; Chung, Hae Young; Jung, Jee H. Bioorganic and Medicinal Chemistry, 2011 , vol. 19, # 4 p. 1520 - 1527

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海关

海关编码	2924199090
中文概述	2924199090. 其他无环酰胺（包括无环氨基甲酸酯)(包括其衍生物及盐）. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:30.0%
申报要素	品名, 成分含量, 用途, 包装
Summary	2924199090. other acyclic amides (including acyclic carbamates) and their derivatives; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%