164650-44-6

• 常用中文名：艾氟康唑
• 常用英文名：Efinaconazole
• CAS号：164650-44-6
• 分子式：C₁₈H₂₂F₂N₄O
• 分子量：348.390
• 相关类别： 原料药 人工合成抗感染类药 抗真菌类药
• 发布时间：2018-04-13 08:00:00
• 更新时间：2026-07-10 14:30:25
• Efinaconazole(KP-103)是新型三唑抗真菌化合物,对T. mentagrophytes SM-110的MIC值为0.0039ug/ml。

名称

• 中文名: 艾菲康唑
• 英文名: efinaconazole
• 中文别名: 爱氟康唑; (2R,3R)-2-(2,4-二氟苯基)-3-(4-亚甲基哌啶基-1-基)-1-(1H-1,2,4-三唑-1-基)丁烷-2-醇; 艾菲康唑及相关杂质; 艾氟康唑,10 MM DMSO 溶液; 艾氟康唑(API); 艾氟康唑/EFINACONAZOLE; (2R,3R)-2-(2,4-二氟苯基)-3-(4-亚甲基哌啶-1-基)-1-(1H-1,2,4-三唑-1-基)-2-丁醇; 伊非那康唑杂质; 艾非康唑; 埃非那康唑; 艾菲康唑/艾氟康唑; 埃非那康唑164-6; (2R,3R)-2-(2,4-二氟苯基)-3-(4-亚甲基哌啶-1-基)-1-(1H-1,2,4-三唑-1-基)丁-2-醇 (艾氟康唑); 艾菲康唑及杂质
• 英文别名: Efinaconazole [USAN:INN]; Efinaconzole; (αR,βR)-α-(2,4-Difluorophenyl)-β-methyl-4-methylene-α-(1H-1,2,4-triazol-1-ylmethyl)-1-piperidineethanol; KP 103 (phmaceutical); EfinaconazoleQ: What is Efinaconazole Q: What is the CAS Number of Efinaconazole Q: What is the storage condition of Efinaconazole Q: What e the applications of Efinaconazole; (R,R)-2-(2,4-Difluorophenyl)-3-(4-methyleniperidin-1-yl)-1-(1,2,4-triazol-1-yl)-2-butanol; KP 103 //BP; (2R,3R)-2-(2,4-Difluorophenyl)-3-(4-methylene-1-piperidinyl)-1-(1H-1,2,4-triazol-1-yl)-2-butanol; (2R,3R)-2-(2,4-Difluorophenyl)-3-(4-methyleniperidin-1-yl)-1-(1,2,4-triazol-1-yl)-2-butanol; (2R,3R)-2-(2,4-Difluorophenyl)-3-(4-methyleniperidin-1-yl)-1-(1H-1,2,4-triazol-1-yl)butan-2-ol (Efinaconazole); JUBLIA; KP 103; KP103; Efinaconazole D4Q: What is Efinaconazole D4 Q: What is the CAS Number of Efinaconazole D4; Efinaconazole (JAN/USAN/INN); Efluconazole; Jublia; Efinaconazole, 10 mM in DMSO; Efinaconazole [INN]; (alph,bet-alpha-(2,4-Difluorophenyl)-beta-methyl-4-methylene-alpha-(1H-1,2,4-triazol-1-ylmethyl)-1-piperidineethanol; UNII-J82SB7FXWB; KP-103; (2R,3R)-2-(2,4-difluorophenyl)-3-(4-methylidenepiperidin-1-yl)-1-(1,2,4-triazol-1-yl)butan-2-ol; Efinaconazole 13CD2; 1-Piperidineethanol, α-(2,4-difluorophenyl)-β-methyl-4-methylene-α-(1H-1,2,4-triazol-1-ylmethyl)-, (αR,βR); Efinaconazole 13CD6; Efinaconazole (Jublia); Efinaconazole In-House

物化性质

• 密度: 1.3±0.1 g/cm3
• 沸点: 512.2±60.0 °C at 760 mmHg
• 分子式: C₁₈H₂₂F₂N₄O
• 分子量: 348.390
• 闪点: 263.6±32.9 °C
• 精确质量: 348.176178
• PSA: 54.18000
• LogP: 3.46
• 蒸汽压: 0.0±1.4 mmHg at 25°C
• 折射率: 1.590
• 储存条件: 2~8℃

生物活性

• 描述: Efinaconazole(KP-103)是新型三唑抗真菌化合物,对T. mentagrophytes SM-110的MIC值为0.0039ug/ml。
• 相关类别:
  信号通路 >> 抗感染 >> 真菌
  研究领域 >> 感染
• 参考文献:

  [1]. Tatsumi Y, et al. Mechanism of action of efinaconazole, a novel triazole antifungal agent. Antimicrob Agents Chemother. 2013 May;57(5):2405-9.

  [2]. Jo Siu WJ, et al. Comparison of in vitro antifungal activities of efinaconazole and currently available antifungal agents against a variety of pathogenic fungi associated with onychomycosis. Antimicrob Agents Chemother. 2013 Apr;57(4):1610-6.

  [3]. Tatsum Y, et al. KP-103, a novel triazole derivative, is effective in preventing relapse and successfully treating experimental interdigital tinea pedis and tinea corporis in guinea pigs. Microbiol Immunol. 2002;46(7):425-32.

安全

• 危害码 (欧洲): Xi