1256963-02-6

• 常用中文名：CDK 4/6抑制剂
• 常用英文名：Ribociclib
• CAS号：1256963-02-6
• 分子式：C₂₂H₂₉ClN₈
• 分子量：440.972
• 相关类别： 原料药 抗肿瘤药 其它抗肿瘤药
• 发布时间：2018-05-03 08:00:00
• 更新时间：2026-07-07 11:38:11
• CDK4-IN-1 is a selective inhibitor of cyclin-dependent kinase 4.

名称

• 中文名: 瑞博西林
• 英文名: 4-(3-chloro-5-propan-2-yl-1H-pyrazol-4-yl)-N-[5-[4-(dimethylamino)piperidin-1-yl]pyridin-2-yl]pyrimidin-2-amine
• 中文别名: CDK4和CDK6抑制剂(LEE011); 4-(5-氯-3-异丙基-1H-吡唑-4-基)-N-(5-(4-(二甲基氨基)哌啶-1-基)吡啶-2-基)嘧啶-2-胺; 瑞博西尼; 医药级苯扎米特; 4-(5-氯-3-异丙基-1H-吡唑-4-基)-N-(5-(4-(二甲基氨基)哌啶-1-基)吡啶-2-基)嘧啶-2-胺瑞博西林; 瑞博西尼-D6*标准物质; 瑞博西尼游离碱; 瑞博西尼碱; 瑞博西林(LEE011)
• 英文别名: Ribociclib Free Base; 4-(5-chloro-3-isopropyl-1H-pyrazol-4-yl)-N-(5-(4-(dimethylamino)piperidin-1-yl)pyridin-2-yl)pyrimidin-2-amine; Ribociclib(LEE011); 4-(3-Chloro-5-isopropyl-1H-pyrazol-4-yl)-N-{5-[4-(dimethylamino)-1-piperidinyl]-2-pyridinyl}-2-pyrimidinamine; CDK4-IN-1; LEE011 //BP; 4-[5-Chloro-3-(1-methylethyl)-1H-pyrazol-4-yl]-N-[5-[4-(dimethylamino)-1-piperidinyl]-2-pyridinyl]-2-pyrimidinamine; CDK4/6 inhibitor; 4-(5-Chloro-3-isopropyl-1H-pyrazol-4-yl)-N-(5-(4-(dimethylamino)piperidin-1-yl)pyridin-2-yl)py; CDK4 inhibitor; 4-(5-Chloro-3-isopropyl-1H-pyrazol-4-yl)-N-(5-(4-(dimethylamino)piperidin-1-yl)pyridin-2-yl)pyrimidin-2-amine; Ribociclib(Lee011 & CDK 4/6 inhibitor); Rebosini; CDK 4/6 Inhibitor, >=; LEE011; 4-(5-Chloro-3-isopropyl-1H-pyrazol-4-yl)-N-{5-[4-(dimethylamino)-1-piperidinyl]-2-pyridinyl}-2-pyrimidinamine; 2-Pyrimidinamine, 4-[3-chloro-5-(1-methylethyl)-1H-pyrazol-4-yl]-N-[5-[4-(dimethylamino)-1-piperidinyl]-2-pyridinyl]; QC-9704

物化性质

• 密度: 1.3±0.1 g/cm3
• 沸点: 679.3±65.0 °C at 760 mmHg
• 分子式: C₂₂H₂₉ClN₈
• 分子量: 440.972
• 闪点: 364.6±34.3 °C
• 精确质量: 440.220367
• PSA: 85.86000
• LogP: 3.19
• 蒸汽压: 0.0±2.1 mmHg at 25°C
• 折射率: 1.644
• 储存条件: 2-8°C

安全

• 危害码 (欧洲): Xi