491871-58-0

• 常用中文名：3-氰基-4-苯基-6-(3-溴-6-羟基苯基)-2(1H)-吡啶酮
• 常用英文名：TCS PIM-1 1
• CAS号：491871-58-0
• 分子式：C₁₈H₁₁BrN₂O₂
• 分子量：367.196
• 相关类别： 信号通路 JAK/STAT信号通路 皮姆
• 发布时间：2016-03-02 23:40:30
• 更新时间：2024-01-02 19:01:12
• TCS PIM-1 1(sc-204330)是ATP竞争性Pim-1激酶抑制剂，IC50为50nM，比对Pim-2和MEK1/MEK2的抑制性较高。

名称

• 中文名: 3-氰基-4-苯基-6-(3-溴-6-羟基苯基)-2(1H)-吡啶酮
• 英文名: 6-(5-Bromo-2-hydroxyphenyl)-2-oxo-4-phenyl-1,2-dihydro-3-pyridine carbonitrile
• 英文别名: 2-oxo-4-phenyl-5H-furan-3-carbonitrile; 6-(5-Bromo-2-hydroxyphenyl)-2-oxo-4-phenyl-1,2-dihydropyridine-3-carbonitrile; TCS PIM-1 1; 3-cyano-4-phenyl-2(5H)-furanone; 3-Cyano-4-phenyl-2(5H)-furanon; 3-Cyan-4-phenyl-2(5H)-furanon; 2-oxo-4-phenyl-2,5-dihydro-furan-3-carbonitrile; 2-oxo-4-phenyl-2,5-dihydro-3-furancarbonitrile; 3-Pyridinecarbonitrile, 6-(5-bromo-2-hydroxyphenyl)-1,2-dihydro-2-oxo-4-phenyl-; 3-cyano-4-phenyl-6-(3-bromo-6-hydroxyphenyl)-2-pyridone; 3-cyano-4-phenyl-6-(3-bromo-6-hydroxy)phenyl-2(1H)-pyridone; 6-(5-Bromo-2-hydroxyphenyl)-2-oxo-4-phenyl-1,2-dihydro-3-pyridinecarbonitrile

物化性质

• 密度: 1.6±0.1 g/cm3
• 沸点: 592.6±50.0 °C at 760 mmHg
• 分子式: C₁₈H₁₁BrN₂O₂
• 分子量: 367.196
• 闪点: 312.2±30.1 °C
• 精确质量: 366.000397
• PSA: 77.14000
• LogP: 4.60
• 蒸汽压: 0.0±1.7 mmHg at 25°C
• 折射率: 1.728
• 储存条件: 2-8℃

生物活性

• 描述: TCS PIM-1 1(sc-204330)是ATP竞争性Pim-1激酶抑制剂,IC50为50nM,比对Pim-2和MEK1/MEK2的抑制性较高。
• 相关类别:
  信号通路 >> JAK/STAT信号通路 >> 皮姆
  研究领域 >> 癌症
• 参考文献:

  [1]. Cheney IW, et al. Identification and structure-activity relationships of substituted pyridones as inhibitors of Pim-1 kinase. Bioorg Med Chem Lett. 2007 Mar 15;17(6):1679-83.

  [2]. Shen Y, et al. Pim-1 inhibitor attenuates trinitrobenzene sulphonic acid induced colitis in the mice. Clin Res Hepatol Gastroenterol. 2018 Sep;42(4):382-386.

合成路线

5067-24-3 107-91-5 ~% 491871-58-0

文献：Cheney, I. Wayne; Yan, Shunqi; Appleby, Todd; Walker, Heli; Vo, Todd; Yao, Nanhua; Hamatake, Robert; Hong, Zhi; Wu, Jim Z. Bioorganic and Medicinal Chemistry Letters, 2007 , vol. 17, # 6 p. 1679 - 1683

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