143393-27-5

• 常用中文名：阿扎兰司他
• 常用英文名：4-({[(2S,4S)-2-[2-(4-Chlorophenyl)ethyl]-2-(1H-imidazol-1-ylmethy l)-1,3-dioxolan-4-yl]methyl}sulfanyl)aniline
• CAS号：143393-27-5
• 分子式：C₂₂H₂₄ClN₃O₂S
• 分子量：429.96300
• 发布时间：2018-03-27 08:00:00
• 更新时间：2024-04-02 09:04:39

名称

• 中文名: 阿扎兰司他
• 英文名: 4-({[(2S,4S)-2-[2-(4-Chlorophenyl)ethyl]-2-(1H-imidazol-1-ylmethy l)-1,3-dioxolan-4-yl]methyl}sulfanyl)aniline
• 英文别名: (2S,4S)-6-Fluoro-2',5'-dioxospiro[chroman-4,4'-imidazolidine]-2-carboxylic acid 2-propyl ester; (2S,4S)-azalanstat; (2S,4S)-2-[2-(4-chlorophenyl)ethyl]-2-[(1H-imidazol-1-yl)methyl]-[{(4-aminophenyl)thio}methyl]-1,3-dioxolane; (2S,4S)-Propyl 6-fluoro-2',5'-dioxospiro[chroman-4,4'-imidazolidine]-2-carboxylate; (2S,4S)-cis-2-(2-(4-chlorophenyl)ethyl)-2-(imidazol-1-yl)methyl-4-(4-aminophenylthio)methyl-1,3-dioxolane; (2S,4S)-6-fluoro-2,3-dihydro-2',5'-dioxospiro<4H-1-benzopyran-4,4'-imidazolidine>-2-carboxylic acid n-propyl ester; (2S,4S)-6-fluoro-2',5'-dioxospiro[chroman-4,4'-imidazolidine]-2-carboxylic acid n-propyl ester; Azetrenatat

物化性质

• 密度: 1.31g/cm3
• 沸点: 647.7ºC at 760mmHg
• 分子式: C₂₂H₂₄ClN₃O₂S
• 分子量: 429.96300
• 闪点: 345.5ºC
• 精确质量: 429.12800
• PSA: 87.60000
• LogP: 5.23670
• 蒸汽压: 1.16E-16mmHg at 25°C
• 折射率: 1.644

合成路线

143327-62-2 1193-02-8 ~87% 143393-27-5

文献：Syntex (U.S.A.) Inc. Patent: US5208331 A1, 1993 ;

1336-21-6 143327-62-2 1193-02-8 ~85% 143393-27-5

文献：Syntex (U.S.A.) Inc. Patent: US5158949 A1, 1992 ;

23735-43-5 ~% 143393-27-5

文献：Walker; Kertesz; Rotstein; Swinney; Berry; So -; Webb; Watson; Mak; Burton; Mills-Dunlap; Chiou; Tokes; Kurz; Kern; Chan; Salari; Mendizabal Journal of Medicinal Chemistry, 1993 , vol. 36, # 15 p. 2235 - 2237