732983-37-8

• 常用中文名：Syk抑制剂IV,BAY 61-3606 HCl
• 常用英文名：BAY 61-3606
• CAS号：732983-37-8
• 分子式：C₂₀H₁₈N₆O₃
• 分子量：390.395
• 相关类别： 信号通路 蛋白酪氨酸激酶 SYK
• 发布时间：2017-12-29 12:13:56
• 更新时间：2026-07-02 11:16:02
• BAY 61-3606是高活性ATP竞争性，可逆的Syk选择性抑制剂，Ki为7.5 nM，对Btk，Fyn，Itk，Lyn和Src无抑制性。

名称

• 中文名: 2-[[7-(3,4-二甲氧基苯基)咪唑并[1,2-C]嘧啶-5-基]氨基]-3-吡啶甲酰胺
• 英文名: 2-[[7-(3,4-dimethoxyphenyl)imidazo[1,2-c]pyrimidin-5-yl]amino]pyridine-3-carboxamide
• 中文别名: 2-((7-(3,4-二甲氧基苯基)咪唑并[1,2-C]嘧啶-5-基)氨基)吡啶-3-甲酰胺; BAY 6 游离碱; BAY 6游离
• 英文别名: SYK INHIBITOR IV; BAY 6 (BAY6); BAY 6 free base; UNII-61G8S0H9KX; BAY 6; Syk Inhibitor IV, BAY 6 HCl; BAY-61-360; 2-((7-(3,4-Dimethoxyphenyl)imidazo[1,2-c]pyrimidin-5-yl)amino)nicotinamide; 2-{[7-(3,4-Dimethoxyphenyl)imidazo[1,2-c]pyrimidin-5-yl]amino}nicotinamide; cc-526; Kinome_3125; BAY 6 hydrate hydrochloride; Syk Inhibitor IV, BAY 6; 2-{[7-(3,4-dimethoxyphenyl)imidazo[1,2-c]pyrimidin-5-yl]amino}pyridine-3-cboxamide; Spleen tyrosine kinase,Syk,inhibit,BAY 61 3606,Apoptosis,Inhibitor,BAY 613606,BAY 6; 2-(7-(3,4-dimethoxyphenyl)imidazo(1,2-c)pyrimidin-5-ylamino)nicotinamide; Syk Inhibitor IV, BAY 6: sc-202351 hydrochloride; 3-Pyridinecboxamide, 2-[[7-(3,4-dimethoxyphenyl)imidazo[1,2-c]pyrimidin-5-yl]amino]; BAY-61-3606 free base; BAY 6, 10 mM in DMSO; 2-[[7-(3,4-Dimethoxyphenyl)imidazo[1,2-c]pyrimidin-5-yl]amino]-3-pyridinecboxamide

物化性质

• 密度: 1.4±0.1 g/cm3
• 分子式: C₂₀H₁₈N₆O₃
• 分子量: 390.395
• 精确质量: 390.144043
• PSA: 116.66000
• LogP: 1.75
• 折射率: 1.696
• 储存条件: 2-8℃

生物活性

• 描述: BAY 61-3606是高活性ATP竞争性,可逆的Syk选择性抑制剂,Ki为7.5 nM,对Btk,Fyn,Itk,Lyn和Src无抑制性。
• 相关类别:
  信号通路 >> 蛋白酪氨酸激酶 >> SYK
  研究领域 >> 炎症/免疫
• 参考文献:

  [1]. Yamamoto N, et al. The orally available spleen tyrosine kinase inhibitor 2-[7-(3,4-dimethoxyphenyl)-imidazo[1,2-c]pyrimidin-5-ylamino]nicotinamide dihydrochloride (BAY 61-3606) blocks antigen-induced airway inflammation in rodents. J Pharmacol Exp Ther. 2

  [2]. Lau KS, et al. BAY61-3606 affects the viability of colon cancer cells in a genotype-directed manner. PLoS One. 2012;7(7):e41343.