113427-24-0

• 常用中文名：阿法依伯汀
• 常用英文名：EPOETIN ALFA
• CAS号：113427-24-0
• 分子式：C₄₂H₇₃NO₁₆
• 分子量：848.02600
• 发布时间：2018-03-18 08:00:00
• 更新时间：2024-01-11 17:22:40

• 慢性肾衰的贫血治疗，包括进行透析和不进行透析的病人；接受化疗癌症病人的贫血治疗；接受叠氮胸苷的艾滋病毒感染病人的贫血治疗。
  

名称

• 中文名: 阿法依伯汀
• 英文名: epoetin alfa
• 中文别名: 重组人红细胞生成素; 重组人促红细胞生成素
• 英文别名: Epoetine alfa; alphaEpoetin; Abseamed; Rhepo; Epoetina alfa; Drg-0062

物化性质

• 分子式: C₄₂H₇₃NO₁₆
• 分子量: 848.02600
• 精确质量: 847.49300
• PSA: 235.76000
• LogP: 0.91010
• 稳定性:

  本品系由哺乳动物细胞培养产生的重组人红细胞生成素，为含165个氨基酸的糖蛋白，与人体内源性促红细胞生成素(erythropoietin)的生物效应相同，可促进骨髓内原始血细胞加速分化，促进有核红细胞加快成熟及血红蛋白合成，并促进网织红细胞和成熟红细胞释放。慢性肾功能衰竭患者血中促红细胞生成素减少或缺乏从而产生贫血。

• 分子结构:

  1、 摩尔折射率：216.46

  2、 摩尔体积（cm³/mol）：665.6

  3、 等张比容（90.2K）：1839.2

  4、 表面张力（dyne/cm）：58.2

  5、 极化率（10-24cm3）：85.81

毒性和生态

CHEMICAL IDENTIFICATION RTECS NUMBER : KF5887500 CHEMICAL NAME : 1-165-Erythropoietin (human clone lambda HEPOFL13 protein moiety), glycoform alpha CAS REGISTRY NUMBER : 113427-24-0 LAST UPDATED : 199506 HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 20 ku/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : IYKEDH Iyakuhin Kenkyu. Study of Medical Supplies. (Nippon Koteisho Kyokai, 12-15, 2-chome, Shibuya, Shibuya-ku, Tokyo 150, Japan) V.1- 1970- Volume(issue)/page/year: 21,319,1990 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Subcutaneous SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 20 ku/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : IYKEDH Iyakuhin Kenkyu. Study of Medical Supplies. (Nippon Koteisho Kyokai, 12-15, 2-chome, Shibuya, Shibuya-ku, Tokyo 150, Japan) V.1- 1970- Volume(issue)/page/year: 21,319,1990 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 20 ku/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : IYKEDH Iyakuhin Kenkyu. Study of Medical Supplies. (Nippon Koteisho Kyokai, 12-15, 2-chome, Shibuya, Shibuya-ku, Tokyo 150, Japan) V.1- 1970- Volume(issue)/page/year: 21,319,1990 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 20 ku/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : IYKEDH Iyakuhin Kenkyu. Study of Medical Supplies. (Nippon Koteisho Kyokai, 12-15, 2-chome, Shibuya, Shibuya-ku, Tokyo 150, Japan) V.1- 1970- Volume(issue)/page/year: 21,319,1990 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Subcutaneous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 20 ku/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : IYKEDH Iyakuhin Kenkyu. Study of Medical Supplies. (Nippon Koteisho Kyokai, 12-15, 2-chome, Shibuya, Shibuya-ku, Tokyo 150, Japan) V.1- 1970- Volume(issue)/page/year: 21,319,1990 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 1270 ku/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : IYKEDH Iyakuhin Kenkyu. Study of Medical Supplies. (Nippon Koteisho Kyokai, 12-15, 2-chome, Shibuya, Shibuya-ku, Tokyo 150, Japan) V.1- 1970- Volume(issue)/page/year: 21,319,1990 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Mammal - dog DOSE/DURATION : 20 ku/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : IYKEDH Iyakuhin Kenkyu. Study of Medical Supplies. (Nippon Koteisho Kyokai, 12-15, 2-chome, Shibuya, Shibuya-ku, Tokyo 150, Japan) V.1- 1970- Volume(issue)/page/year: 21,319,1990

安全

• 危险品运输编码: NONH for all modes of transport