95-80-7

95-80-7结构式

常用中文名：2,4-二氨基甲苯
常用英文名：2,4-Diaminotoluene
CAS号：95-80-7
分子式：C₇H₁₀N₂
分子量：122.168
相关类别：化学试剂有机试剂多胺
发布时间：2018-06-12 16:55:17
更新时间：2025-08-20 17:35:43
【用途一】
用于制取TDI、硫化染料、碱性染料、分散染料、医药中间体及其他有机合成的中间体
【用途二】
有机合成中间体。用于生产甲苯二异氰酸酯，染料毛皮黑DB、硫化黄棕5G、硫化黄棕6G、硫化红棕B3R等。制成的染料可使皮毛、头发直接氧化成黑色。
【用途三】
是有机合成原料之一，可制取甲苯二异氰酸酯。也用作染料中间体、毛发染黑

中文名	2,4-二氨基甲苯
英文名	2,4-diaminotoluene
中文别名	4-甲基间苯二胺 4-甲基-1,3-苯二胺 2,4-二氨基甲间甲苯二胺 2,4-二胺甲苯-2,4-二胺
英文别名	4-Methylbenzene-1,3-diamine 2,4-TDA tertralg 2,4-TOLUENEDIAMINE 4-Methyl-1,3-benzenediamine 2,4-diamino-toluene Fouramine EINECS 202-453-1 Toluene-2,4-diamine 1,3-diamino-4-methyl-benzene MFCD00007804 UNII-IS1AKN4HYB 2,4-Diaminotoluene 2,4-toluylenediamine

密度	1.1±0.1 g/cm3
沸点	292.0±0.0 °C at 760 mmHg
熔点	97-99 °C(lit.)
分子式	C₇H₁₀N₂
分子量	122.168
闪点	149.5±21.3 °C
精确质量	122.084396
PSA	52.04000
LogP	0.15
外观性状	无色晶体
蒸汽压	0.0±0.6 mmHg at 25°C
折射率	1.636
储存条件	1.储存注意事项储存于阴凉、通风的库房。远离火种、热源。包装密封。应与氧化剂、酸类、食用化学品分开存放，切忌混储。配备相应品种和数量的消防器材。储区应备有合适的材料收容泄漏物。 2.采用铁桶包装，每桶５０ｋｇ。贮存时要防潮、防晒。为防止氧化，加入适量的还原剂。按有毒危险品规定贮运。
稳定性	1.有毒。其毒性及防护方法参见邻苯二胺。 2.稳定性稳定 3.禁配物强氧化剂、酸类、酰基氯、酸酐、氯仿 4.避免接触的条件受热 5.聚合危害不聚合 6.分解产物氨
水溶解性	50 g/l (25 ºC)
分子结构	1、摩尔折射率：39.55 2、摩尔体积（cm³/mol）：110.2 3、等张比容（90.2K）：296.5 4、表面张力（dyne/cm）：52.3 5、介电常数： 6、偶极距（10^-24cm³）： 7、极化率：15.67
计算化学	1.疏水参数计算参考值（XlogP）:无 2.氢键供体数量:2 3.氢键受体数量:2 4.可旋转化学键数量:0 5.互变异构体数量:无 6.拓扑分子极性表面积52 7.重原子数量:9 8.表面电荷:0 9.复杂度:92.9 10.同位素原子数量:0 11.确定原子立构中心数量:0 12.不确定原子立构中心数量:0 13.确定化学键立构中心数量:0 14.不确定化学键立构中心数量:0 15.共价键单元数量:1
更多	1.性状：无色针状或菱形结晶。 2.熔点（℃）：97~99 3.沸点（℃）：292 4.饱和蒸气压（kPa）：0.13（106.5℃） 5.临界压力（MPa）：4.38 6.辛醇/水分配系数：0.337 7.引燃温度（℃）：477 8.溶解性：溶于水，易溶于乙醇、乙醚、苯。

国标编号:	61800
ＣＡＳ:	95-80-7
中文名称:	2，4-二氨基甲苯
英文名称:	2,4-Diaminotoluene；Toluene-2,4-diamine
别名:	甲苯-2，4-二胺
分子式:	C₇H₁₀N₂；H₃CC₆H₃(NH₂)₂
分子量:	122.17
熔点:	99℃ 沸点：280℃
密度:
蒸汽压:
溶解性:	溶于水、乙醇、乙醚
稳定性:	稳定
外观与性状:	无色针状或菱形结晶
危险标记:	15(毒害品)
用途:	是有机合成原料之一，可制取甲苯二异氰酸酯。也用作染料中间体、毛发染黑

2.对环境的影响:
一、健康危害

侵入途径：吸入、食入、经皮吸收。
健康危害：对粘膜、呼吸道及皮肤有刺激作用。吸入、摄入或经皮肤吸收可引起中毒。可引起湿疹、类似丹毒的痂皮。中毒表现有支气管炎、气管炎、喘息等。

二、毒理学资料及环境行为

毒性：中等毒性。
急性毒性：LD50260mg/kg(大鼠经口)
致突变性：微粒体致突变：鼠伤寒沙门氏菌100μg/皿。
致癌性：IARC致癌性评论：对人可能致癌。

危险特性：遇明火、高热可燃。与强氧化剂可发生反应。受热分解放出有毒的氧化氮烟气。
燃烧(分解)产物：一氧化碳、二氧化碳、氧化氮。

3.现场应急监测方法:
　

4.实验室监测方法:
色谱/质谱法《水和有害废物的监测分析方法》周文敏等编译

5.环境标准:
前苏联(1975)车间卫生标准 2mg/m3
前苏联(1995)水体中有害物质最高允许浓度 1.0mg/L

6.应急处理处置方法:
一、泄漏应急处理

隔离泄漏污染区，周围设警告标志，建议应急处理人员戴好防毒面具，穿化学防护服。不要直接接触泄漏物，用清洁的铲子收集于干燥净洁有盖的容器中，运至废物处理场所。也可以用大量水冲洗，经稀释的洗水放入废水系统。如大量泄漏，收集回收或无害处理后废弃。

二、防护措施

呼吸系统防护：高浓度环境中，佩带防毒面具。紧急事态抢救或逃生时，应该佩戴自给式呼吸器。
眼睛防护：戴化学安全防护眼镜。
防护服：穿紧袖工作服，长统胶鞋。
手防护：戴橡皮手套。
其它：工作现场禁止吸烟、进食和饮水。及时换洗工作服。工作前不饮酒，用温水洗澡。进行就业前和定期的体检。

三、急救措施

皮肤接触：立即脱去污染的衣着，用肥皂水及清水彻底冲洗。
眼睛接触：立即提起眼睑，用大量流动清水或生理盐水冲洗。
吸入：迅速脱离现场至空气新鲜处。保持呼吸道通畅。必要时进行人工呼吸。就医。
食入：误服者给漱口，饮水，洗胃后口服活性炭，再给以导泻。就医。

灭火方法：雾状水、二氧化碳、砂土、干粉、泡沫。

毒理学数据:

1.急性毒性 LD50：590mg/kg（大鼠经口，24h）；650mg/kg（兔经皮，24h）

2.刺激性

家兔经皮：500mg（24h），轻度刺激。

家兔经眼：100mg（24h），重度刺激。

3.致突变性微生物致突变：鼠伤寒沙门菌100μg/皿。DNA损伤：人成纤维细胞100μmol/L。程序外DNA合成：人类肝脏100μmol/L。微核试验：大鼠经口300mg/kg。

4.致癌性 IARC致癌性评论：G2B，可疑人类致癌物。

生态学数据:

1.生态毒性

LC50：1420mg/L（96h）（黑头呆鱼）

EC50：1290~1440mg/L（96h）（黑头呆鱼）

2.生物降解性

好氧生物降解（h）：672~4320

厌氧生物降解（h）：2688~17280

3.非生物降解性

水中光氧化半衰期（h）：31~1740

空气中光氧化半衰期（h）：0.27~2.7

CHEMICAL IDENTIFICATION

RTECS NUMBER :: XS9625000

CHEMICAL NAME :: Toluene-2,4-diamine

CAS REGISTRY NUMBER :: 95-80-7

BEILSTEIN REFERENCE NO. :: 2205839

LAST UPDATED :: 199712

DATA ITEMS CITED :: 64

MOLECULAR FORMULA :: C7-H10-N2

MOLECULAR WEIGHT :: 122.19

WISWESSER LINE NOTATION :: ZR CZ D1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: Standard Draize test

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rabbit

TYPE OF TEST :: Standard Draize test

ROUTE OF EXPOSURE :: Administration into the eye

SPECIES OBSERVED :: Rodent - rabbit

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 325 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 350 mg/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Cardiac - pulse rate Lungs, Thorax, or Respiration - respiratory stimulation

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 480 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Mammal - dog

DOSE/DURATION :: 200 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 400 mg/kg

TOXIC EFFECTS :: Brain and Coverings - other degenerative changes Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - respiratory stimulation

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 2100 mg/kg/90W-C

TOXIC EFFECTS :: Tumorigenic - Carcinogenic by RTECS criteria Liver - tumors Skin and Appendages - tumors

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 8050 mg/kg/101W-C

TOXIC EFFECTS :: Tumorigenic - Carcinogenic by RTECS criteria Liver - tumors Blood - lymphoma, including Hodgkin's disease

TYPE OF TEST :: TD - Toxic dose (other than lowest)

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 17 gm/kg/2Y-C

TOXIC EFFECTS :: Tumorigenic - Carcinogenic by RTECS criteria Liver - tumors Blood - lymphoma, including Hodgkin's disease

TYPE OF TEST :: TD - Toxic dose (other than lowest)

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 5030 mg/kg/84W-C

TOXIC EFFECTS :: Tumorigenic - Carcinogenic by RTECS criteria Liver - tumors Blood - lymphoma, including Hodgkin's disease

TYPE OF TEST :: TD - Toxic dose (other than lowest)

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 9000 mg/kg/36W-C

TOXIC EFFECTS :: Tumorigenic - Carcinogenic by RTECS criteria Liver - tumors

TYPE OF TEST :: TD - Toxic dose (other than lowest)

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 8400 mg/kg/2Y-C

TOXIC EFFECTS :: Tumorigenic - Carcinogenic by RTECS criteria Liver - tumors

TYPE OF TEST :: TD - Toxic dose (other than lowest)

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 16800 mg/kg/2Y-C

TOXIC EFFECTS :: Tumorigenic - Carcinogenic by RTECS criteria Liver - tumors

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 1260 mg/kg

SEX/DURATION :: male 10 week(s) pre-mating

TOXIC EFFECTS :: Reproductive - Fertility - mating performance (e.g. # sperm positive females per # females mated; # copulations per # estrus cycles)

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 1260 mg/kg

SEX/DURATION :: male 10 week(s) pre-mating

TOXIC EFFECTS :: Reproductive - Paternal Effects - spermatogenesis (incl. genetic material, sperm morphology, motility, and count) Reproductive - Paternal Effects - prostate, seminal vesicle, Cowper's gland, accessory glands

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 210 mg/kg

SEX/DURATION :: male 1 week(s) pre-mating

TOXIC EFFECTS :: Reproductive - Paternal Effects - spermatogenesis (incl. genetic material, sperm morphology, motility, and count) Reproductive - Paternal Effects - testes, epididymis, sperm duct

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 1200 mg/kg

SEX/DURATION :: female 6-13 day(s) after conception

TOXIC EFFECTS :: Reproductive - Fertility - litter size (e.g. # fetuses per litter; measured before birth) Reproductive - Effects on Newborn - live birth index (measured after birth)

TYPE OF TEST :: Sex chromosome loss and nondisjunction

TYPE OF TEST :: Sex chromosome loss and nondisjunction

TYPE OF TEST :: Micronucleus test

TYPE OF TEST :: DNA adduct

TYPE OF TEST :: DNA damage

TYPE OF TEST :: Unscheduled DNA synthesis

TYPE OF TEST :: DNA inhibition

TYPE OF TEST :: Sister chromatid exchange

MUTATION DATA

TYPE OF TEST :: Mutation in mammalian somatic cells

TEST SYSTEM :: Rodent - hamster Ovary

REFERENCE :: MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 135,115,1984 *** REVIEWS *** IARC Cancer Review:Animal Sufficient Evidence IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 16,83,1978 IARC Cancer Review:Human No Adequate Data IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 16,83,1978 IARC Cancer Review:Group 2B IMSUDL IARC Monographs, Supplement. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) No.1- 1979- Volume(issue)/page/year: 7,56,1987 *** OCCUPATIONAL EXPOSURE LIMITS *** OEL-FINLAND;Carcinogen JAN 1993 OEL-GERMANY;Carcinogen JAN 1993 OEL-RUSSIA:STEL 2 mg/m3;Skin JAN 1993 OEL-SWEDEN;Carcinogen JAN 1993 OEL-SWITZERLAND;Carcinogen JAN 1993 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH RECOMMENDED EXPOSURE LEVEL (REL) : NIOSH REL TO TOLUENEDIAMINE-air:CA lowest feasible concentration REFERENCE : NIOSH* National Institute for Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda. Volume(issue)/page/year: DHHS #92-100,1992 NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X5386 No. of Facilities: 130 (estimated) No. of Industries: 6 No. of Occupations: 15 No. of Employees: 8511 (estimated) No. of Female Employees: 396 (estimated)

符号	GHS06, GHS08, GHS09
信号词	Danger
危害声明	H301-H312-H317-H341-H350-H361f-H373-H411
警示性声明	P201-P273-P280-P301 + P310-P308 + P313
个人防护装备	Eyeshields;Faceshields;full-face particle respirator type N100 (US);Gloves;respirator cartridge type N100 (US);type P1 (EN143) respirator filter;type P3 (EN 143) respirator cartridges
危害码 (欧洲)	T:Toxic
风险声明 (欧洲)	R21;R25;R36;R43;R45;R51/53
安全声明 (欧洲)	S53-S45-S61
危险品运输编码	UN 1709 6.1/PG 3
WGK德国	3
RTECS号	XS9625000
包装等级	III
危险类别	6.1(b)
海关编码	29331990

上游产品 10
121-14-2 606-20-2 584-84-9 29213-02-3
1866-39-3 99-55-8 386756-54-3 618-85-9
602-01-7 610-39-9
下游产品 10
106917-61-7 5421-66-9 141922-21-6 1519-71-7
221875-98-5 2095-01-4 2095-02-5 19318-83-3
29455-59-2 99-55-8

海关编码	2921519020
中文概述	2921519020 2,4-二氨基甲苯。监管条件:X(有毒化学品环境管理放行通知单)。增值税率:17.0%。退税率:17.0%。最低关税:6.5%。普通关税:30.0%
申报要素	品名, 成分含量, 用途
监管条件	X.有毒化学品环境管理放行通知单
Summary	2921519020 4-methylbenzene-1,3-diamine。supervision conditions:x(environment control release notice for poisonous chemicals)。VAT:17.0%。tax rebate rate:17.0%。MFN tarrif:6.5%。general tariff:30.0%

1503408-51-2	1574318-13-0
1502272-40-3	1538777-93-3
1441895-72-2	1807940-72-2
1521457-40-8	1609407-72-8
55654-81-4	1797709-70-6

95-80-7

CHEMICAL IDENTIFICATION

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

MUTATION DATA

本网页内容来自不同专业数据源，如对内容有疑义，欢迎联系service1@chemsrc.com。