132682-77-0

• 常用中文名：2-二苯基膦-6-甲基吡啶
• 常用英文名：2-Diphenylphosphino-6-methylpyridine
• CAS号：132682-77-0
• 分子式：C₁₈H₁₆NP
• 分子量：277.30000
• 相关类别： 医药中间体 杂环化合物 吡啶类化合物 甲基吡啶
• 发布时间：2018-07-30 23:04:18
• 更新时间：2024-01-02 20:28:23
• 下载msds

名称

• 中文名: 2-二苯基膦-6-甲基吡啶
• 英文名: 2-Diphenylphosphino-6-methylpyridine
• 英文别名: (6-methylpyridin-2-yl)-diphenylphosphane

物化性质

• 沸点: 390.3ºC at 760 mmHg
• 熔点: 81-83ºC
• 分子式: C₁₈H₁₆NP
• 分子量: 277.30000
• 闪点: 189.9ºC
• 精确质量: 277.10200
• PSA: 26.48000
• LogP: 3.14820
• 外观性状: crystal | white to off-white
• 蒸汽压: 6.01E-06mmHg at 25°C
• 储存条件:

  密闭于阴凉干燥环境中

• 稳定性:

  遵照规定使用和储存则不会分解。

• 分子结构:

  1、摩尔折射率：无可用

  2、 摩尔体积（cm³/mol）：无可用

  3、 等张比容（90.2K）：无可用

  4、 表面张力（dyne/cm）：无可用

  5、 极化率：无可用

• 计算化学:

  1.疏水参数计算参考值（XlogP）:4.3

  2.氢键供体数量:0

  3.氢键受体数量:1

  4.可旋转化学键数量:3

  5.互变异构体数量:无

  6.拓扑分子极性表面积12.9

  7.重原子数量:20

  8.表面电荷:0

  9.复杂度:263

  10.同位素原子数量:0

  11.确定原子立构中心数量:0

  12.不确定原子立构中心数量:0

  13.确定化学键立构中心数量:0

  14.不确定化学键立构中心数量:0

  15.共价键单元数量:1

• 更多:

  1. 性状：无可用

  2. 密度（g/mL,25/4℃）：无可用

  3. 相对蒸汽密度（g/mL,空气=1）：无可用

  4. 熔点（ºC）：81-83

  5. 沸点（ºC,常压）：无可用

  6. 沸点（ºC,5.2kPa）：无可用

  7. 折射率：无可用

  8. 闪点（ºC）：无可用

  9. 比旋光度（º）：无可用

  10. 自燃点或引燃温度（ºC）：无可用

  11. 蒸气压（kPa,25ºC）：无可用

  12. 饱和蒸气压（kPa,60ºC）：无可用

  13. 燃烧热（KJ/mol）：无可用

  14. 临界温度（ºC）：无可用

  15. 临界压力（KPa）：无可用

  16. 油水（辛醇/水）分配系数的对数值：无可用

  17. 爆炸上限（%,V/V）：无可用

  18. 爆炸下限（%,V/V）：无可用

  19. 溶解性：无可用

MSDS

Section 1: Product Identification Chemical Name:2-Diphenylphosphino-6-methylpyridine, 98% CAS Registry Number:132682-77-0 Formula:C18H16NP EINECS Number:none Chemical Family:organophosphine ligand Synonym:2-Diphenylphosphanyl-6-methyl-pyridine Section 2: Composition and Information on Ingredients IngredientCAS NumberPercentACGIH (TWA)OSHA (PEL) Title compound132682-77-0100%no datano data Section 3: Hazards Identification Emergency Overview:Irritating to skin, eyes and respiratory tract. May be harmful if swallowed. Primary Routes of Exposure:Inhalation, skin, eyes Eye Contact:Causes moderate irritation of the eyes. Skin Contact:Causes mild to moderate irritation of the skin. Inhalation:Inhalation causes irritation to the nose, mucous membranes and respiratory tract. Ingestion:No specific information is available on the physiological effects of ingestion. Acute Health Affects:Irritating to skin, eyes and respiratory tract. Chronic Health Affects:No information on long-term chronic effects. NTP:No IARC:No OSHA:No SECTION 4: First Aid Measures Immediately flush the eyes with copious amounts of water for at least 10-15 minutes. A victim may need Eye Exposure: assistance in keeping their eye lids open. Get immediate medical attention. Wash the affected area with water. Remove contaminated clothes if necessary. Seek medical assistance if Skin Exposure: irritation persists. Remove the victim to fresh air. Closely monitor the victim for signs of respiratory problems, such as difficulty Inhalation: in breathing, coughing, wheezing, or pain. In such cases seek immediate medical assistance. Seek medical attention immediately. Keep the victim calm. Give the victim water (only if conscious). Induce Ingestion: vomiting only if directed by medical personnel. SECTION 5: Fire Fighting Measures Flash Point:no data Autoignition Temperature:none Explosion Limits:none Extinguishing Medium:carbon dioxide, dry powder or foam. Fire fighters should be equipped with a NIOSH approved positive pressure self-contained breathing apparatus Special Fire Fighting Procedures: and full protective clothing. Hazardous Combustion andIf involved in a fire this material may emit toxic organic fumes and vapors of phosphorus pentoxide. Decomposion Products: Unusual Fire or Explosion Hazards: No unusual fire or explosion hazard. SECTION 6: Accidental Release Measures Small spills can be mixed with vermiculite, sodium carbonate or other suitable non combustible adsorbent and Spill and Leak Procedures: swept up. SECTION 7: Handling and Storage Handling and Storage:Store the material in a cool, dry place in a tightly sealed container. SECTION 8: Exposure Controls and Personal Protection Eye Protection:Always wear approved safety glasses when handling a chemical substance in the laboratory. Skin Protection:Wear protective clothing and gloves. Ventilation:Handle the material in an efficient fume hood. If ventilation is not available a respirator should be worn. The use of respirators requires a Respirator Respirator: Protection Program to be in compliance with 29 CFR 1910.134. Ventilation:Handle the material in an efficient fume hood. Additional Protection:No additional protection required. SECTION 9: Physical and Chemical Properties Color and Form:white to off-white xtl. Molecular Weight:277.3 Melting Point:81-83 ° Boiling Point:no data Vapor Pressure:no data Specific Gravity:no data Odor:not determined Solubility in Water:insoluble SECTION 10: Stability and Reactivity Stability:air and moisture stable Hazardous Polymerization:no hazardous polymerization Conditions to Avoid:none Incompatibility:strong oxidizing agents and halogens Decomposition Products:carbon dioxide, carbon monoxide, organic fumes and phosphorus oxides. SECTION 11: Toxicological Information RTECS Data:No information available in the RTECS files. Carcinogenic Effects:no data Mutagenic Effects:no data Tetratogenic Effects:no data SECTION 12: Ecological Information Ecological Information:No information available SECTION 13: Disposal Considerations Disposal:Dispose of according to federal, state, and local regulations. SECTION 14: Transportation Shipping Name (CFR):Non-hazardous Hazard Class (CFR):NA Additional Hazard Class (CFR):NA Packaging Group (CFR):NA UN ID Number (CFR):NA Shipping Name (IATA):Non-hazardous Hazard Class (IATA):NA Additional Hazard Class (IATA):NA Packaging Group (IATA):NA UN ID Number (IATA):NA SECTION 15: Regulatory Information TSCA:Not listed in the TSCA inventory. SARA (Title 313):Title compound not listed. Second Ingredient:none SECTION 16 - ADDITIONAL INFORMATION N/A

毒性和生态

生态学数据: 该物质对环境可能有危害，对水体应给予特别注意。

安全

• 危害码 (欧洲): Xi
• 风险声明 (欧洲): R36/37/38
• 安全声明 (欧洲): 26-36/37/39
• 海关编码: 29333990

合成路线

18368-63-3 829-85-6 ~90% 132682-77-0

文献：Grotjahn, Douglas B.; Lev, Daniel A. Journal of the American Chemical Society, 2004 , vol. 126, # 39 p. 12232 - 12233

1109288-90-5 ~87% 132682-77-0

文献：Li, Yuehui; Lu, Liang-Qiu; Das, Shoubhik; Pisiewicz, Sabine; Junge, Kathrin; Beller, Matthias Journal of the American Chemical Society, 2012 , vol. 134, # 44 p. 18325 - 18329

5315-25-3 1079-66-9 ~77% 132682-77-0

文献：Shell Oil Company Patent: US5166411 A1, 1992 ;

5315-25-3 4559-70-0 ~91% 132682-77-0

文献：Li, Yuehui; Das, Shoubhik; Zhou, Shaolin; Junge, Kathrin; Beller, Matthias Journal of the American Chemical Society, 2012 , vol. 134, # 23 p. 9727 - 9732

18368-63-3 1079-66-9 ~66% 132682-77-0

文献：Scrivanti; Beghetto; Matteoli Advanced Synthesis and Catalysis, 2002 , vol. 344, # 5 p. 543 - 547

5315-25-3 829-85-6 ~31% 1109288-90-5 132682-77-0

文献：Chemistry - A European Journal, , vol. 18, # 31 p. 9622 - 9627

65567-06-8 ~% 132682-77-0

文献：Inorganic Chemistry, , vol. 52, # 5 p. 2292 - 2305

1079-66-9 ~% 132682-77-0

文献：Inorganic Chemistry, , vol. 52, # 5 p. 2292 - 2305

上下游产品

上游产品  7
18368-63-3 829-85-6 1109288-90-5 5315-25-3
1079-66-9 4559-70-0 65567-06-8
下游产品  0