10403-51-7

• 常用中文名：米丁度胺
• 常用英文名：4,8-Ethenopyrrolo[3',4':3,4]cyclobut[1,2-f]isoindole-1,3,5,7(2H,6H)-tetrone,3a,3b,4,4a,7a,8,8a,8b-octahydro-, (3aR,3bS,4R,4aR,7aS,8S,8aR,8bS)-rel-
• CAS号：10403-51-7
• 分子式：C₁₄H₁₂N₂O₄
• 分子量：272.25600
• 发布时间：2018-02-23 08:00:00
• 更新时间：2024-01-14 10:38:26

名称

• 中文名: 米丁度胺
• 英文名: Mitindomide
• 英文别名: Benzenebismaleimide adduct; tricyclo<4.2.2.02,5>dec-9-ene-3,4,7,8-tetracarboxylic acid diimide; 3a,3b,4,4a,7a,8,8b-octahydro-4,8-ethenopyrrolo[3',4':3,4]cyclobut[1,2-f]isoindole-1,3,5,7[2H,6H]tetrone

物化性质

• 密度: 1.518g/cm3
• 沸点: 618.2ºC at 760mmHg
• 分子式: C₁₄H₁₂N₂O₄
• 分子量: 272.25600
• 闪点: 270ºC
• 精确质量: 272.08000
• PSA: 92.34000
• 蒸汽压: 3.26E-15mmHg at 25°C
• 折射率: 1.627

毒性和生态

CHEMICAL IDENTIFICATION RTECS NUMBER : YD2143000 CAS REGISTRY NUMBER : 10403-51-7 LAST UPDATED : 199612 DATA ITEMS CITED : 3 MOLECULAR FORMULA : C14-H12-N2-O4 MOLECULAR WEIGHT : 272.28 HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : LD - Lethal dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : >5 gm/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : PCJOAU Pharmaceutical Chemistry Journal (English Translation). Translation of KHFZAN. (Plenum Pub. Corp., 233 Spring St., New York, NY 10013) No.1- 1967- Volume(issue)/page/year: 25,38,1991 TYPE OF TEST : LD - Lethal dose ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : >5 gm/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : PCJOAU Pharmaceutical Chemistry Journal (English Translation). Translation of KHFZAN. (Plenum Pub. Corp., 233 Spring St., New York, NY 10013) No.1- 1967- Volume(issue)/page/year: 25,38,1991 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 193 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : NCISP* National Cancer Institute Screening Program Data Summary, Developmental Therapeutics Program. (Bethesda, MD 20205) Volume(issue)/page/year: JAN1986

合成路线

541-59-3 71-43-2 ~% 10403-51-7

文献：Bryce-Smith, D.; Gilbert, A.; Al-Jalal, N.; Deshpande, R.R.; Grzonka, J.; et al. Zeitschrift fuer Naturforschung, Teil B: Anorganische Chemie, Organische Chemie, 1983 , vol. 38, # 9 p. 1101 - 1112

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