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57021-61-1

57021-61-1结构式
57021-61-1结构式
  • 常用中文名:异尼辛
  • 常用英文名:isonixin
  • CAS号:57021-61-1
  • 分子式:C14H14N2O2
  • 分子量:242.27300
  • 相关类别: 研究领域 炎症/免疫
  • 发布时间:2018-06-25 17:36:31
  • 更新时间:2024-01-10 14:45:51
  • Isonixin(Isonixine)是一种非甾体化合物。Isonixin可用于疼痛和炎症的研究[1][2][3][4]。

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中文名 异尼辛
英文名 isonixin
英文别名 Nixyn hermes
N-(2,6-Dimethylphenyl)-1,2-dihydro-2-oxo-3-pyridinecarboxamide
Nixyn
1,2-Dihydro-2-oxo-N-(2,6-xylyl)-3-pyridinecarboxamide
Isonixine
描述 Isonixin(Isonixine)是一种非甾体化合物。Isonixin可用于疼痛和炎症的研究[1][2][3][4]。
相关类别
体内研究 异烟碱可延长小鼠的己巴比妥睡眠时间,减少运动活动,拮抗心梗诱发的惊厥,引起体温过高,并抑制震颤素诱发的颤抖[1]。异烟碱(p.o.)显示出3.15小时的吸收半衰期,并在胃肠道中迅速吸收[2]。异烟碱(静脉注射、胃内注射和十二指肠内注射)主要通过尿液排泄,异烟碱可在50小时内被尿液清除[3]。异烟碱(2000 mg/kg;每天口服一次,持续6个月)对雄性兔子和大鼠有轻微的毒性作用,不会引起胃肠道损伤[4]。
密度 1.244g/cm3
沸点 520.5ºC at 760 mmHg
分子式 C14H14N2O2
分子量 242.27300
闪点 217.5ºC
精确质量 242.10600
PSA 61.96000
LogP 2.31700
折射率 1.628

CHEMICAL IDENTIFICATION

RTECS NUMBER :
US4600000
CHEMICAL NAME :
3-Pyridinecarboxamide, 1,2-dihydro-2-oxo-N-(2,6-xylyl)-
CAS REGISTRY NUMBER :
57021-61-1
LAST UPDATED :
199210
DATA ITEMS CITED :
5
MOLECULAR FORMULA :
C14-H14-N2-O2
MOLECULAR WEIGHT :
242.30
WISWESSER LINE NOTATION :
T6MVJ CVMR B1 F1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
>6 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 27,1457,1977
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
>2 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 27,1457,1977
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
7 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 27,1457,1977
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
>2 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 27,1457,1977 ** OTHER MULTIPLE DOSE TOXICITY DATA **
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
281 gm/kg/26W-I
TOXIC EFFECTS :
Liver - changes in liver weight Blood - changes in serum composition (e.g. TP, bilirubin, cholesterol) Related to Chronic Data - death
REFERENCE :
ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 27,1460,1977