256487-77-1

• 常用中文名：N-Boc-4-羰基-L-脯氨酸甲酯
• 常用英文名：N-Boc-4-oxo-L-proline methyl ester
• CAS号：256487-77-1
• 分子式：C₁₁H₁₇NO₅
• 分子量：243.256
• 相关类别： 生物化工 氨基酸及其衍生物 脯氨酸类衍生物
• 发布时间：2018-12-16 13:53:39
• 更新时间：2026-07-01 19:58:33

名称

• 中文名: N-Boc-4-羰基-L-脯氨酸甲酯
• 英文名: 1-O-tert-butyl 2-O-methyl (2R)-4-oxopyrrolidine-1,2-dicarboxylate
• 中文别名: 1-叔丁基2-甲基(2R)-4-氧吡咯烷-1,2-二羧酸酯; N-BOC-4-氧-D-脯氨酸甲酯; N-BOC-4-氧代-D-脯氨酸甲酯; (R)-N-BOC-4-羰基脯氨酸甲酯; (R)-1-叔丁基2-甲基4-氧代吡咯烷-1,2-二羧酸酯; (R)-1-叔丁基2-甲基4-氧代吡咯啉-1,2-二甲酸酯; (2R)-4-氧代-1,2-吡咯烷二羧酸 1-(1,1-二甲基乙基) 2-甲酯; 1-叔-丁基 2-甲基 (2R)-4-氧亚基吡咯烷-1,2-二甲酸基酯; (R)-N-BOC-4-氧代脯氨酸甲酯; N -BOC- 4 -羰基- L -脯氨酸酯; N -BOC- 4 -羰基- L -脯氨酸甲酯; (2R)-4-氧代吡咯烷-1,2-二羧酸 1-叔丁酯 2-甲酯; BOC-4-氧代-D-脯氨酸甲酯; N -BOC- 4 -羰基- D -脯氨酸甲酯; N-叔丁氧羰基-4-氧代-D-脯氨酸甲酯
• 英文别名: Methyl (2R)-1-Boc-4-oxo-pyrrolidinecboxylate; Boc-ketopyrrolidine methyl ester; (R)-N-Boc-2-Methoxycbonyl-4-pyrrolidone; 2-Methyl-1-{[(2-methyl-2-propanyl)oxy]carbonyl}-4-oxo-D-proline; (R)-4-Oxo-pyrrolidine-1,2-dicboxylic acid 1-tert-butyl ester 2-methyl ester; 1-tert-butyl 2-methyl (2R)-4-oxopyrrolidine-1,2-dicarboxylate; (R)-N-Boc-2-methoxycarbonyl-4-pyrrolidone; N-Boc-4-oxo-L-Pro.Ome; N-Boc-4- oxygen -D- proline methyl ester; Boc-4-oxo-D-proline methyl ester; (2R)-4-oxo-1,2-Pyrrolidinedicboxylic acid 1-(tert-butyl) 2-methyl ester; 4-oxopyrrolidine-N-1,2-(R)-dicarboxylic acid 1-tert-butyl ester 2-methyl ester; N-Boc-4-oxo-L-proline m; Methyl N-Boc-4-keto-D-prolinate; Boc-4-oxo-D-proline Methyl ester; (2R)-4-oxo-1,2-Pyrrolidinedicboxylic acid 1-(1,1-dimethylethyl) 2-methyl ester; 1,2-Pyrrolidinedicboxylic acid, 4-oxo-, 1-(1,1-dimethylethyl) 2-methyl ester, (2R); N-Boc-4-oxo-L-proline methyl ester //BP; 1-(tert-Butyl) 2-methyl (R)-4-oxopyrrolidine-1,2-dicboxylate; 1-O-tert-butyl 2-O-methyl (2R)-4-oxopyrrolidine-1,2-dicboxylate; 1-tert-butyl 2-Methyl (2R)-4-oxopyrrolidine-1,2-dicboxylate; (2R)-N-Boc-4-oxo-D-proline methyl ester; methyl (R)-1-tert-butoxycbonyl-4-oxopyrrolidine-2-cboxylate; 4-oxopyrrolidine-1,2R-dicarboxylic acid 1-tert-butyl ester 2-methyl ester; PS-J-119; Boc-4-OXO-D-Pro-Ome; (R)-1-TERT-BUTYL 2-METHYL 4-OXOPYRROLIDINE-1,2-DICARBOXYLATE; 1-tert-butyl 2-methyl (R)-4-oxopyrrolidine-1,2-dicarboxylate

物化性质

• 密度: 1.3±0.1 g/cm3
• 沸点: 386.8±42.0 °C at 760 mmHg
• 分子式: C₁₁H₁₇NO₅
• 分子量: 243.256
• 闪点: 187.7±27.9 °C
• 精确质量: 243.110672
• PSA: 72.91000
• LogP: 0.10
• 蒸汽压: 0.0±1.9 mmHg at 25°C
• 折射率: 1.506
• 储存条件: 2~8℃

安全

• 危害码 (欧洲): Xi
• 海关编码: 2933990090

合成路线

114676-69-6 ~84% 256487-77-1

文献：WO2012/125887 A1, ; Page/Page column 74-75 ; WO 2012/125887 A1

135042-17-0 ~70% 256487-77-1

文献：Organic Letters, , vol. 11, # 6 p. 1245 - 1248

114676-59-4 ~% 256487-77-1

文献：Journal of Medicinal Chemistry, , vol. 42, # 26 p. 5426 - 5436

2584-71-6 ~% 256487-77-1

文献：Journal of Medicinal Chemistry, , vol. 42, # 26 p. 5426 - 5436

24424-99-5 ~% 256487-77-1

文献：Journal of Medicinal Chemistry, , vol. 42, # 26 p. 5426 - 5436

178962-09-9 ~% 256487-77-1

文献：Bioorganic and Medicinal Chemistry Letters, , vol. 21, # 12 p. 3771 - 3773

3398-22-9 ~% 256487-77-1

文献：Bioorganic and Medicinal Chemistry Letters, , vol. 21, # 12 p. 3771 - 3773

135042-12-5 ~% 256487-77-1

文献：WO2012/162635 A1, ; WO 2012/162635 A1

上下游产品

上游产品  8
114676-69-6 135042-17-0 114676-59-4 2584-71-6
24424-99-5 178962-09-9 3398-22-9 135042-12-5
下游产品  1
475561-89-8

海关

海关编码	2933990090
中文概述	2933990090. 其他仅含氮杂原子的杂环化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%
申报要素	品名, 成分含量, 用途, 乌洛托品请注明外观, 6－己内酰胺请注明外观, 签约日期
Summary	2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%