69123-94-0

• 常用中文名：1-(2-脱氧-2-氟-β-D-阿拉伯呋喃糖)尿嘧啶
• 常用英文名：2'-Deoxy-2'-fluorouridine
• CAS号：69123-94-0
• 分子式：C₉H₁₁FN₂O₅
• 分子量：246.19
• 相关类别： 生物化工 糖类化合物 单糖
• 发布时间：2018-12-26 13:51:48
• 更新时间：2026-08-01 23:03:23
• 1-(2-脱氧-2-氟-β-D-阿拉伯呋喃基)尿嘧啶是嘌呤核苷类似物。嘌呤核苷类似物具有广泛的抗肿瘤活性,靶向惰性淋巴系统恶性肿瘤。这一过程中的抗癌机制依赖于抑制DNA合成、诱导细胞凋亡等[1]。

名称

• 中文名: 1-(2-脱氧-2-氟-beta-D-阿拉伯呋喃基)尿嘧啶
• 英文名: 1-(2-Deoxy-2-fluoro-b-D-arabinofuranosyl)uracil
• 中文别名: 1-(2'-脱氧-2'-氟-Β-D-阿拉伯呋喃基)尿嘧啶; 2-脱氧-2'-氟-Β-D-阿拉伯尿苷; 1-(2-脱氧-2-氟-Β-D-阿拉伯呋喃基)尿嘧啶; 1-(2-脱氧-2-氟-BETA-D-阿拉伯呋喃基)尿嘧啶(; 2'-氟-阿糖尿苷; 2′-脱氧-2′-氟阿糖尿苷; 1-((2R,3S,4R,5R)-3-氟-4-羟基-5-(羟甲基)四氢呋喃-2-基)嘧啶-2,4(1H,3H)-二酮; 2'-脱氧-2'-氟-BETA-D-阿糖尿苷,2'-氟-阿糖尿苷; 1-(2-脱氧-2-氟-Β-D-阿拉伯呋喃糖)尿嘧啶; 泛素样核糖体蛋白S30/MNSF-Β抗体
• 英文别名: 1-(2-Deoxy-2-fluoro-β-D-arabinofuranosyl)-2,4(1H,3H)-pyrimidinedione; 2’-Deoxy-2’-fluoro-b-D-abinouridine, antiviral anticancer agent; 2'-Fluoro-2'-deoxy-abinofuranosyl-uridine; 2'-Fluoro-2'-deoxy-β-Dabino-furanosyluridine; 2’-Deoxy-2’-fluoro-beta-D-abinouridine; 2'-Deoxy-2'-fluoro-beta-D-abinouridine; 1-((2R,3S,4R,5R)-3-fluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)pyrimidine-2,4(1H,3H)-dione; 2,4(1H,3H)-PYRIMIDINEDIONE, 1-(2-DEOXY-2-FLUORO-BETA-D-ABINOFURANOSYL); 1-((2R,3S,4R,5R)-3-FLUORO-4-HYDROXY-5-HYDROXYMETHYL-TETRAHYDRO-FURAN-2-YL)-1H-PYRIMIDINE-2,4-DIONE; 2'-Fluoro-2'-deoxy-β-D-abino-furanosyluridine; 2,4(1H,3H)-Pyrimidinedione, 1-(2-deoxy-2-fluoro-β-D-abinofuranosyl); 2'-Fluoro-2'-deoxy-abino-Uridine; 1-[(2R,3S,4R,5R)-3-fluoro-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]pyrimidine-2,4-dione; 2'-FLUORO 2'-DEOXYURACIL-BETA-D-ABINOFURANOSIDE; 2'-Fluoro-abinofuranosyl-2'-deoxy-uridine; 1-(2'-Deoxy-2'-fluoro-b-D-abinofuranosyl)uracil; 1,3-Dimethyl-4-Amino-5-Formamide-Uracil FAU; 1-(2-Deoxy-2-fluoro-β-D-arabinofuranosyl)pyrimidine-2,4(1H,3H)-dione; 2’-fluoro-5-ethyl-1-beta-d-abinofuranosyluracil; antiviral anticancer agent; 2’-Deoxy-2’-fluoro-β-D-abinouridine; 1-[(2R,3S,4R,5R)-3-Fluoro-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]pyrimidine-2,4-dione; 2'-Fluoro-2'-deoxyuridine; 2'-Deoxy-2'-fluoro-D-abinouridine; 1-(2-deoxy-2-fluoro-beta-d-abinofuranosyl)-uraci; 2’-Deoxy-2’-fluoro-b-D-abinouridine; 1-[(2R,3S,4R,5R)-3-fluoro-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]-1,2,3,4-tetrahydropyrimidine-2,4-dione; 2'-FLUORO-2'-DEOXYURACYL-BETA-D-ABINOFURANOSIDE; 1-(2-Deoxy-2-fluoro-beta-D-abinofuranosyl)uracil; 2-Deoxy-2'-fluoro-β-D-abinouridine; a-2'-F-2'-dU; 1-(2-Deoxy-2-fluoro-β-D-abinofuranosyl)uracil; 2,4(1H,3H)-PyriMidinedione, 1-(2-deoxy-2-fluoro-b-D-abinofuranosyl); 1-(2-Deoxy-2-fluoro-β-D-arabinofuranosyl)uracil; 2'-FANA-uridine

物化性质

• 密度: 1.6±0.1 g/cm3
• 分子式: C₉H₁₁FN₂O₅
• 分子量: 246.19
• 精确质量: 246.065201
• PSA: 104.55000
• LogP: -1.31
• 外观性状: 无色固体
• 折射率: 1.608
• 储存条件: 2-8°C

生物活性

• 描述: 1-(2-脱氧-2-氟-β-D-阿拉伯呋喃基)尿嘧啶是嘌呤核苷类似物。嘌呤核苷类似物具有广泛的抗肿瘤活性,靶向惰性淋巴系统恶性肿瘤。这一过程中的抗癌机制依赖于抑制DNA合成、诱导细胞凋亡等[1]。
• 相关类别:
  信号通路 >> 细胞周期/DNA损伤 >> 核苷抗代谢药/类似物
  研究领域 >> 其他
• 参考文献:

  [1]. Robak T, Robak P. Purine nucleoside analogs in the treatment of rarer chronic lymphoid leukemias. Curr Pharm Des. 2012;18(23):3373-88.

毒性和生态

CHEMICAL IDENTIFICATION RTECS NUMBER : YQ9512000 CHEMICAL NAME : Uracil, 1-(2-deoxy-2-fluoro-beta-D-arabinofuranosyl)- CAS REGISTRY NUMBER : 69123-94-0 LAST UPDATED : 198708 DATA ITEMS CITED : 4 MOLECULAR FORMULA : C11-H15-F-N2-O5 MOLECULAR WEIGHT : 274.28 WISWESSER LINE NOTATION : T6NVMVJ E2 A- BT5OTJ CF DQ E1Q HEALTH HAZARD DATA ACUTE TOXICITY DATA MUTATION DATA TYPE OF TEST : Mutation test systems - not otherwise specified TEST SYSTEM : Rodent - rat Bone marrow DOSE/DURATION : 3700 umol/L REFERENCE : PAACA3 Proceedings of the American Association for Cancer Research. (Waverly Press, 428 E. Preston St., Baltimore, MD 21202) V.1- 1954- Volume(issue)/page/year: 26,333,1985

安全

• 海关编码: 2934999090

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海关编码	2934999090
中文概述	2934999090. 其他杂环化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%
申报要素	品名, 成分含量, 用途
Summary	2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%