34041-84-4

34041-84-4结构式

常用中文名：盐酸双氯芬酸
常用英文名：Diclofensine (hydrochloride)
CAS号：34041-84-4
分子式：C₁₇H₁₈Cl₃NO
分子量：358.690
相关类别：信号通路神经信号通路多巴胺转运蛋白
发布时间：2017-06-12 23:32:31
更新时间：2026-07-03 04:04:28
Diclofensine盐酸盐(Ro-8-4650)是高效单胺再摄取抑制剂,大鼠脑突触体中阻断多巴胺、去甲肾上腺素和5-羟色胺的IC50值分别为0.74、2.3和3.7nM。

中文名	盐酸双氯芬酸
英文名	Diclofensine Hydrochloride
中文别名	4-(3,4-二氯苯)-7-甲氧基-2-甲基-1,2,3,4-四氢异喹啉盐酸盐双氮奋兴盐酸盐
英文别名	Ro 0 hydrochloride Diclofensine Hydrochloride 1.0 mg/ml in Methanol (as free base) Isoquinoline, 4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydro-7-methoxy-2-methyl-, hydrochloride (1:1) 4-(3,4-Dichlorophenyl)-7-methoxy-2-methyl-1,2,3,4-tetrahydroisoqu inoline hydrochloride (1:1) Ro 0 hydrochlorid DICLOFENSINE HCL UNII:8U71XY6JQK 4-(3,4-dichlorophenyl)-7-Methoxy-2-Methyl-1,2,3,4-tetrahydroisoquinoline hydrochloride Diclofensine hydrochloride,SLC6A3,DAT,Inhibitor,Ro 0,inhibit,Diclofensine,Dopamine Transporter Isoquinoline, 4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydro-7-methoxy-2-methyl-, hydrochloride Ro-8-4650 hydrochloride 4-(3,4-Dichlorophenyl)-7-methoxy-2-methyl-1,2,3,4-tetrahydroisoquinoline hydrochloride (1:1)

描述	Diclofensine盐酸盐(Ro-8-4650)是高效单胺再摄取抑制剂,大鼠脑突触体中阻断多巴胺、去甲肾上腺素和5-羟色胺的IC50值分别为0.74、2.3和3.7nM。
相关类别	信号通路 >> 神经信号通路 >> 多巴胺转运蛋白研究领域 >> 神经疾病
参考文献	[1]. Hyttel J, et al. Neurochemical profile of Lu 19-005, a potent inhibitor of uptake of dopamine, noradrenaline, and serotonin. J Neurochem. 1985 May;44(5):1615-22. [2]. Gasic S, et al. Effect of diclofensine, a novel antidepressant, on peripheral adrenergic function. Clin Pharmacol Ther. 1986 May;39(5):582-5. [3]. Di Renzo G, et al. Pure uptake blockers of dopamine can reduce prolactin secretion: studies with diclofensine. Life Sci. 1988;42(21):2161-9.