28149-48-6

• 常用中文名：4-(二乙氧基次膦基甲基)苯甲酸
• 常用英文名：4-diethoxy-phosphoryl-methylbenzoic acid
• CAS号：28149-48-6
• 分子式：C₁₂H₁₇O₅P
• 分子量：272.234
• 发布时间：2018-03-22 08:00:00
• 更新时间：2025-08-26 19:50:38

名称

• 中文名: 4-(二乙氧基膦甲基)苯甲酸
• 英文名: 4-(diethoxyphosphorylmethyl)benzoic acid
• 中文别名: 4-[(二乙氧基磷酰基)甲基]苯甲酸; 4-甲磷酸二乙酯基苯甲酸; 甲磷酸二乙酯基苯甲酸
• 英文别名: 4-((diethoxyphosphoryl)Methyl)benzoic acid; Benzoic acid, 4-[(diethoxyphosphinyl)methyl]; α-Phosphono-p-toluic Acid P,P-Diethyl Ester; 4-[(Diethoxyphosphoryl)methyl]benzoic acid; 4-diethoxyphosphinoylmethylbenzoic acid; diethyl 4-carboxybenzylphosphonic acid; F9995-0119; 4-Cboxyphenyl Phosphonate; 4-(Diethoxyphosphinylmethyl)benzoic Acid; ((Diethoxyphosphoryl)methyl)benzoic acid

物化性质

• 密度: 1.2±0.1 g/cm3
• 沸点: 427.9±38.0 °C at 760 mmHg
• 分子式: C₁₂H₁₇O₅P
• 分子量: 272.234
• 闪点: 212.6±26.8 °C
• 精确质量: 272.081360
• PSA: 82.64000
• LogP: 1.74
• 蒸汽压: 0.0±1.1 mmHg at 25°C
• 折射率: 1.518

合成路线

6232-88-8 122-52-1 ~96% 28149-48-6

文献：AXYS PHARMACEUTICALS, INC. Patent: WO2005/118584 A2, 2005 ; Location in patent: Page/Page column 68-69 ;

2417-72-3 122-52-1 ~84% 28149-48-6

文献：Bardecker, Julie A.; Afzali, Ali; Tulevski, George S.; Graham, Teresita; Hannon, James B.; Jen, Alex K.-Y. Journal of the American Chemical Society, 2008 , vol. 130, # 23 p. 7226 - 7227

6232-88-8 ~% 28149-48-6

文献：G. D. Searle and Co. Patent: US4918064 A1, 1990 ;

1642-81-5 762-04-9 ~10% 28149-48-6

文献：Laven, Gaston; Kalek, Marcin; Jezowska, Martina; Stawinski, Jacek New Journal of Chemistry, 2010 , vol. 34, # 5 p. 967 - 975

78-40-0 6232-88-8 ~% 28149-48-6

文献：Chen, Xiaoqi; Kopecky, David J.; Mihalic, Jeff; Jeffries, Shawn; Min, Xiaoshan; Heath, Julie; Deignan, Jeff; Lai, Sujen; Fu, Zice; Guimaraes, Cristiano; Shen, Shanling; Li, Shyun; Johnstone, Sheree; Thibault, Stephen; Xu, Haoda; Cardozo, Mario; Shen, Wang; Walker, Nigel; Kayser, Frank; Wang, Zhulun Journal of Medicinal Chemistry, 2012 , vol. 55, # 8 p. 3837 - 3851

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