350228-37-4

• 常用中文名：人脑淀粉样前体蛋白 (APP) Β-分泌酶多肽
• 常用英文名：(Asn670,Sta671,Val672)-Amyloid β/A4 Protein Precursor770 (662-675) ammonium salt
• CAS号：350228-37-4
• 分子式：C₇₃H₁₁₈N₁₆O₂₇
• 分子量：1651.809
• 相关类别： 信号通路 神经信号通路 β-分泌
• 发布时间：2016-10-20 15:48:40
• 更新时间：2026-07-01 16:39:43
• β-Secretase inhibitor ([Asn670, Sta671, Val672]-Amyloid β Peptide (662-675)) 是一种 β-分泌酶 和 BACE1 抑制剂 (对 β-分泌酶 IC< sub>50 为 25 nM)。

名称

• 中文名: 人脑淀粉样前体蛋白 (APP) Β-分泌酶多肽
• 英文名: h-lys-thr-glu-glu-ile-ser-glu-val-asn-sta-val-ala-glu-phe-oh
• 中文别名: Β-分泌酶抑制剂KTEEISEVN-STA-VAEF
• 英文别名: -Secretase Inhibitor mg; Lys-THR-E-Glu-I-S-E-Val-ASN-STA-Val-A-E-Phe; b-secretase inhibitor; B-SECRETASE INHIBITOR; (2S,5S,8S,11S,15S,16S,19S,22S,25S,28S,31S,34S,37S)-19-(2-Amino-2-oxoethyl)-2-benzyl-31-[(2S)-2-butanyl]-5,25,34-tris(2-carboxyethyl)-37-{[(2S,3R)-2-{[(2S)-2,6-diaminohexanoyl]amino}-3-hydroxybutanoyl]amino}-15-hydroxy-28-(hydroxymethyl)-16-isobutyl-11,22-diisopropyl-8-methyl-4,7,10,13,18,21,24,27,30,33,36-undecaoxo-3,6,9,12,17,20,23,26,29,32,35-undecaazatetracontane-1,40-dioic acid (non-preferred name); LYS-THR-GLU-GLU-ILE-SER-GLU-VAL-ASN(STATIN)-VAL-ALA-GLU-PHE-OH; (ASN670,STA671,VAL672)-APP770; (Asn670,Sta671,Val672)-Amyloid β/A4 Protein Precursor770 (662-675); L-Lysyl-L-threonyl-L-alpha-glutamyl-L-alpha-glutamyl-L-isoleucyl-L-seryl-L-alpha-glutamyl-L-valyl-L-aspaginyl-(3S,4S)-4-amino-3-hydroxy-6-methylhtanoyl-L-valyl-L-alanyl-L-alpha-glutamyl-L-phenylalanine; (Asn670,Sta671,Val672)-Amyloid β/A4 Protein Precursor770; KTEETSEVN(STAT)VAEF; APP BETA-SECRETASE INHIBITOR; kteeisevn-sta-vaef; BACE-IN-1; BETA-SECRETASE INHIBITOR 1; LYS-THR-GLU-GLU-ILE-SER-GLU-VAL-ASN(STATINE)-VAL-ALA-GLU-PHE-OH; (ASN670,STA671,VAL672)-AMYLOID BETA/A4 PROTEIN PRECURSOR770; (Asn,Sta1,Val2)-Amyloid β/A4 Protein Precursor ammonium salt; (Asn670,Sta671,Val672)-AMyloid b/A4 Protein Precursor770; A4 PROTEIN PRECURSOR770; L-Phenylalanine, L-lysyl-L-threonyl-L-α-glutamyl-L-α-glutamyl-L-isoleucyl-L-seryl-L-α-glutamyl-L-valyl-L-aspaginyl-(3S,4S)-4-amino-3-hydroxy-6-methylhtanoyl-L-valyl-L-alanyl-L-α-glutamyl; KTEEISEVN [STATINE] VAEF; [ASN670, STA671, VAL672]AMYLOID-BETA; KTEEISEVN-STA-VAEF; KTEEISEVN-Sta-VAEF(Sta=statine); H-LYS-THR-GLU-GLU-ILE-SER-GLU-VAL-ASN-STA-VAL-ALA-GLU-PHE-OH; (Asn670, Sta671,Val672)-Amyloid b/A4 Protein Precursor770 ammonium; (Asn670,Sta671,Va672)-Amyloid β/A4 Protein Precursor770 ammonium salt; (Asn,Sta,Val)-Amyloid β/A4 Protein Precursor ammonium salt; BETA-SECRETASE INHIBITOR; LYS-THR-GLU-GLU-ILE-SER-GLU-VAL-ASN-STA-VAL-ALA-GLU-PHE; (2S,5S,8S,11S,15S,16S,19S,22S,25S,28S,31S,34S,37S)-19-(2-Amino-2-oxoethyl)-2-benzyl-31-[(2S)-butan-2-yl]-5,25,34-tris(2-carboxyethyl)-37-{[(2S,3R)-2-{[(2S)-2,6-diaminohexanoyl]amino}-3-hydroxybutanoyl]amino}-15-hydroxy-28-(hydroxymethyl)-16-isobutyl-11,22-diisopropyl-8-methyl-4,7,10,13,18,21,24,27,30,33,36-undecaoxo-3,6,9,12,17,20,23,26,29,32,35-undecaazatetracontane-1,40-dioic acid (non-preferred name); AMYLOID PRECURSOR PROTEIN BETA-SECRETASE INHIBITOR; LYS-THR-GLU-GLU-ILE-SER-GLU-VAL-ASN-[STATINE]-VAL-ALA-GLU-PHE; P10-P4' StatVal; Asn670, Sta671, Val672]-Amyloid β Ptide

物化性质

• 密度: 1.3±0.1 g/cm3
• 沸点: 1976.1±65.0 °C at 760 mmHg
• 分子式: C₇₃H₁₁₈N₁₆O₂₇
• 分子量: 1651.809
• 闪点: 1148.9±34.3 °C
• 精确质量: 1650.835205
• PSA: 720.62000
• LogP: -2.42
• 蒸汽压: 0.0±0.3 mmHg at 25°C
• 折射率: 1.562

生物活性

• 描述: β-Secretase inhibitor ([Asn670, Sta671, Val672]-Amyloid β Peptide (662-675)) 是一种 β-分泌酶 和 BACE1 抑制剂 (对 β-分泌酶 IC< sub>50 为 25 nM)。
• 相关类别:
  信号通路 >> 神经信号通路 >> β-分泌
  研究领域 >> 神经疾病
• 参考文献:

  [1]. Lin Liu, et al. A colorimetric strategy for assay of protease activity based on gold nanoparticle growth controlled by ascorbic acid and Cu(II)-coordinated peptide. Sensors and Actuators B: Chemical. Volume 266, 1 August 2018, Pages 246-254.

  [2]. Zhou Y, et al. Tyrosine-Conjugation Method for Evaluating BACE1 Activity Based on Silver Nanoparticles/Metal-Organic Framework Composites as Electrochemical Tags. Chemistry. 2023 May 16;29(28):e202300450.