350228-37-4

• 常用中文名：(Asn670,Sta671,Val672)-Amyloid β/A4 Protein Precursor770 (662-675) ammonium salt
• 常用英文名：(Asn670,Sta671,Val672)-Amyloid β/A4 Protein Precursor770 (662-675) ammonium salt
• CAS号：350228-37-4
• 分子式：C₇₃H₁₁₈N₁₆O₂₇
• 分子量：1651.809
• 相关类别： 信号通路 神经信号通路 β-分泌
• 发布时间：2016-10-20 15:48:40
• 更新时间：2024-01-04 19:23:12
• β-Secretase inhibitor ([Asn670, Sta671, Val672]-Amyloid β Peptide (662-675)) 是一种 β-分泌酶 和 BACE1 抑制剂 (对 β-分泌酶 IC< sub>50 为 25 nM)。

名称

• 英文名: h-lys-thr-glu-glu-ile-ser-glu-val-asn-sta-val-ala-glu-phe-oh
• 英文别名: L-Aspartamide, L-lysyl-L-threonyl-L-α-glutamyl-L-α-glutamyl-L-isoleucyl-L-seryl-L-α-glutamyl-L-valyl-N-[(1S,2S,6S,9S,12S,15S)-15-carboxy-12-(2-carboxyethyl)-2-hydroxy-9-methyl-6-(1-meth ylethyl)-1-(2-methylpropyl)-4,7,10,13-tetraoxo-16-phenyl-5,8,11,14-tetraazahexadec-1-yl]-; L-Aspartamide, L-lysyl-L-threonyl-L-α-glutamyl-L-α-glutamyl-L-isoleucyl-L-seryl-L-α-glutamyl-L-valyl-N-[(1S,2S,6S,9S,12S,15S)-15-carboxy-12-(2-carboxyethyl)-2-hydroxy-9-methyl-6-(1-methylethyl)-1-(2-methylpropyl)-4,7,10,13-tetraoxo-16-phenyl-5,8,11,14-tetraazahexadec-1-yl]-; (2S,5S,8S,11S,15S,16S,19S,22S,25S,28S,31S,34S,37S)-19-(2-Amino-2-oxoethyl)-2-benzyl-31-[(2S)-butan-2-yl]-5,25,34-tris(2-carboxyethyl)-37-{[(2S,3R)-2-{[(2S)-2,6-diaminohexanoyl]amino}-3-hydroxybutanoyl]amino}-15-hydroxy-28-(hydroxymethyl)-16-isobutyl-11,22-diisopropyl-8-methyl-4,7,10,13,18,21,24,27,30,33,36-undecaoxo-3,6,9,12,17,20,23,26,29,32,35-undecaazatetracontane-1,40-dioic acid (non-preferred name); kteeisevn-sta-vaef; b-secretase inhibitor; (2S,5S,8S,11S,15S,16S,19S,22S,25S,28S,31S,34S,37S)-19-(2-Amino-2-oxoethyl)-2-benzyl-31-[(2S)-2-butanyl]-5,25,34-tris(2-carboxyethyl)-37-{[(2S,3R)-2-{[(2S)-2,6-diaminohexanoyl]amino}-3-hydroxybutanoyl]amino}-15-hydroxy-28-(hydroxymethyl)-16-isobutyl-11,22-diisopropyl-8-methyl-4,7,10,13,18,21,24,27,30,33,36-undecaoxo-3,6,9,12,17,20,23,26,29,32,35-undecaazatetracontane-1,40-dioic acid (non-preferred name); KTEEISEVN-Sta-VAEF(Sta=statine); (Asn670,Sta671,Val672)-Amyloid β/A4 Protein Precursor770 (662-675)

物化性质

• 密度: 1.3±0.1 g/cm3
• 沸点: 1976.1±65.0 °C at 760 mmHg
• 分子式: C₇₃H₁₁₈N₁₆O₂₇
• 分子量: 1651.809
• 闪点: 1148.9±34.3 °C
• 精确质量: 1650.835205
• PSA: 720.62000
• LogP: -2.42
• 蒸汽压: 0.0±0.3 mmHg at 25°C
• 折射率: 1.562

生物活性

• 描述: β-Secretase inhibitor ([Asn670, Sta671, Val672]-Amyloid β Peptide (662-675)) 是一种 β-分泌酶 和 BACE1 抑制剂 (对 β-分泌酶 IC< sub>50 为 25 nM)。
• 相关类别:
  信号通路 >> 神经信号通路 >> β-分泌
  研究领域 >> 神经疾病
• 参考文献:

  [1]. Lin Liu, et al. A colorimetric strategy for assay of protease activity based on gold nanoparticle growth controlled by ascorbic acid and Cu(II)-coordinated peptide. Sensors and Actuators B: Chemical. Volume 266, 1 August 2018, Pages 246-254.

  [2]. Zhou Y, et al. Tyrosine-Conjugation Method for Evaluating BACE1 Activity Based on Silver Nanoparticles/Metal-Organic Framework Composites as Electrochemical Tags. Chemistry. 2023 May 16;29(28):e202300450.