4548-34-9

• 常用中文名：(1S,2R)-2-苯基环丙胺盐酸盐
• 常用英文名：Tranylcypromine (2-PCPA) HCl
• CAS号：4548-34-9
• 分子式：C₉H₁₂ClN
• 分子量：169.65100
• 相关类别： 信号通路 表观遗传学 组蛋白去甲基化酶
• 发布时间：2018-08-24 16:55:47
• 更新时间：2026-07-14 11:41:20
• (1S,2R)-氨酰环丙烷盐酸盐是一种有效的抗抑郁剂。(1S,2R)-盐酸川芎嗪可抑制MAO和LSD1[1][2]。

名称

• 中文名: 盐酸环苯丙胺
• 英文名: tranylcypromine hydrochloride
• 中文别名: (1S,2R)-反苯环丙胺(盐酸盐); (1S,2R)-2-苯基-环丙胺盐酸盐
• 英文别名: (+)-Tranylcypromine hydrochloride; (+)-Tranylcypromine HydrochlorideQ: What is (+)-Tranylcypromine Hydrochloride Q: What is the CAS Number of (+)-Tranylcypromine Hydrochloride Q: What is the storage condition of (+)-Tranylcypromine Hydrochloride Q: What e the applications of (+)-Tranylcypromine Hydrochloride; (1S,2R)-Tranylcypromine (hydrochloride); (1S,2R)-2-Phenylcyclopropan-1-amine hydrochloride; Tranylcypromine; (1S,2R)-2-Phenyl-cyclopropylamine hydrochloride; (+)-Tranylcypromine HCl; Tranylcypromine Hydrochloride (1.0 mg/mL in Methanol); (+)-TRANYLCYPROMINE HYDROCHLORIDE; TranylcyproMine (2-PA) HCl; (1S,2R)-2-Phenylcyclopropanamine hydrochloride

物化性质

• 分子式: C₉H₁₂ClN
• 分子量: 169.65100
• 精确质量: 169.06600
• PSA: 26.02000
• LogP: 3.00350
• 储存条件: -20℃

生物活性

• 描述: (1S,2R)-氨酰环丙烷盐酸盐是一种有效的抗抑郁剂。(1S,2R)-盐酸川芎嗪可抑制MAO和LSD1[1][2]。
• 相关类别:
  信号通路 >> 表观遗传学 >> 组蛋白去甲基化酶
  信号通路 >> 神经信号通路 >> 单胺氧化酶
  研究领域 >> 神经疾病
• 参考文献:

  [1]. TetsuyaEzawa, et al. Amidation of carboxylic acids via the mixed carbonic carboxylic anhydrides and its application to synthesis of antidepressant (1S,2R)-tranylcypromine. Tetrahedron: Asymmetry. 15 December 2017;28(12):1690-1699.

  [2]. Valente S, et al. Pure Diastereomers of a Tranylcypromine-Based LSD1 Inhibitor: Enzyme Selectivity and In-Cell Studies. ACS Med Chem Lett. 2014 Dec 8;6(2):173-7.