260273-82-3

• 常用中文名：3-(2-氯乙基)-9-羟基-2-甲基-4H-吡啶并[1,2-a]嘧啶-4-酮
• 常用英文名：3-(2-Chloroethyl)-9-hydroxy-2-methyl-4H-pyrido[1,2-a]pyrimidin-4-one
• CAS号：260273-82-3
• 分子式：C₁₁H₁₁ClN₂O₂
• 分子量：238.670
• 相关类别： 医药中间体 杂环化合物 吡啶类化合物 乙基吡啶
• 发布时间：2018-12-31 18:57:42
• 更新时间：2024-01-11 19:52:56

名称

• 中文名: 3-(2-氯乙基)-2-甲基-9-羟基-4H-吡啶并[1,2A]嘧啶-4酮 (帕潘立酮)
• 英文名: 3-(2-Chloroethyl)-2-methyl-9-hydroxy-4H-pyrido[1,2-a]pyrimidin-4-one (Paliperidone)
• 中文别名: 3-(2-氯乙基)-9-羟基-2-甲基-4H-吡啶并[1,2-a]嘧啶-4-酮; 帕利哌酮杂质1
• 英文别名: 4H-Pyrido[1,2-a]pyrimidin-4-one, 3-(2-chloroethyl)-9-hydroxy-2-methyl-; 3-(2-chloroethyl)-9-hydroxy-2-methyl-4H-pyrido[1,2-a]pyrimidine-4-one; 3-(2-Chloroethyl)-2-methyl-9-hydroxy-4H-pyrido[1,2-a]pyrimidin-4-one(Paliperidone); 3-(2-chloroethyl)-2-methyl-9-hydroxy-4H-pyrido[1,2-a]pyrimidin-4-one; 3-(2-chloroethyl)-2-Methyl-9-hydroxy-4H-pyrido[1,2-a]pyriMidine-4-one; 9-hydroxy-3-(2-chloroethyl)-2-methyl-4H-pyrido[1,2-a]pyrimidin-4-one; 3-(2-chloroethyl)-6,7,8,9-tetrahydro-9-hydroxy-2- methyl-4H-pyrido [1,2-a]pyrimidine-4-one; MFCD11110969

物化性质

• 密度: 1.4±0.1 g/cm3
• 沸点: 413.1±55.0 °C at 760 mmHg
• 分子式: C₁₁H₁₁ClN₂O₂
• 分子量: 238.670
• 闪点: 203.6±31.5 °C
• 精确质量: 238.050903
• PSA: 54.60000
• LogP: 1.66
• 蒸汽压: 0.0±2.2 mmHg at 25°C
• 折射率: 1.635

合成路线

16867-03-1 517-23-7 ~% 260273-82-3

文献：ACTAVIS GROUP PTC EHF Patent: US2010/4447 A1, 2010 ; Location in patent: Page/Page column 3 ;

147687-17-0 ~63% 130049-82-0 260273-82-3

文献：GLENMARK GENERICS LIMITED Patent: WO2009/130710 A2, 2009 ; Location in patent: Page/Page column 17-18 ;

517-23-7 24016-03-3 ~% 260273-82-3

文献：WATSON LABORATORIES, INC.; CHAVAN, Amit, Anant; BHANU, Manjunath, Narayan; JOSHI, Ashutosh, Vijay Patent: WO2012/134445 A1, 2012 ; Location in patent: Page/Page column 26; 27 ;

517-23-7 ~% 260273-82-3

文献：CADILA HEALTHCARE LIMITED; DWIVEDI, Shriprakash, Dhar; PATEL, Dhimant, Jasubhai; ROY, Rushikesh, Udaykumar; PATEL, Mayur, Ramnikbhai Patent: WO2011/73997 A2, 2011 ;

16867-03-1 ~% 260273-82-3

文献：CADILA HEALTHCARE LIMITED; DWIVEDI, Shriprakash, Dhar; PATEL, Dhimant, Jasubhai; ROY, Rushikesh, Udaykumar; PATEL, Mayur, Ramnikbhai Patent: WO2011/73997 A2, 2011 ;

849727-62-4 ~% 260273-82-3

文献：CADILA HEALTHCARE LIMITED; DWIVEDI, Shriprakash, Dhar; PATEL, Dhimant, Jasubhai; ROY, Rushikesh, Udaykumar; PATEL, Mayur, Ramnikbhai Patent: WO2011/73997 A2, 2011 ; Location in patent: Page/Page column 14 ;