55749-97-8

55749-97-8结构式

中文名	GLP-GLN-TRP-ALA-VAL-GLY-HIS-PHE-MET-NH2
英文名	Litorin
中文别名	两栖类铃蟾肽样肽LITORIN 雨滨蛙肽
英文别名	PYR-GLN-TRP-ALA-VAL-GLY-HIS-PHE-MET-NH2 2-De-L-Val-3-de-L-Pro-ranatensin 5-Oxo-L-Pro-L-Gln-L-Trp-L-Ala-L-Val-Gly-L-His-L-Phe-L-Met-NH2 pGlu-Gln-Trp-Ala-Val-Gly-His-Phe-Met-NH2 GLP-GLN-TRP-ALA-VAL-GLY-HIS-PHE-MET-NH2 M.W. 1084.47 C51H68N14O11S Pituitary adenylate cyclase activating fragment 21-38 LITORIN pGlu-Gln-Trp-Ala-Val-Gly-His-Phe-Met-NH2,Pituitary adenylate cyclase activating fragment 21-38 Efonidipine hydrochloride monoethanolate Litorin TFA salt pGlu-Gln-Trp-Ala-Val-Gly-His-Phe-Met-NH2, Pituity adenylate cyclase activating fragment Pituity adenylate cyclase activating fragment GLP-GLN-TRP-ALA-VAL-GLY-HIS-PHE-MET-NH2: GLP-QWAVGHFM-NH2 C51H68N14O11S L-Methioninamide, 5-oxo-L-prolyl-L-glutaminyl-L-tryptophyl-L-alanyl-L-valylglycyl-L-histidyl-L-phenylalanyl

描述	利托林是一种两栖类蛙皮素肽衍生物,是蛙皮素受体激动剂。Litorin刺激平滑肌收缩,刺激胃泌素、胃酸和胰腺分泌,并在体内抑制营养物质[1][2]。
相关类别	研究领域 >> 代谢疾病信号通路 >> G 蛋白偶联受体/G 蛋白 >> Bombesin Receptor
体外研究	99mTc-Litorin用于对胃泌素释放肽受体(GRP-R)过度表达的肿瘤进行无创成像[1]。[D-Phe1,Leu8,9]Litorin抑制125I-[Tyr4]BN与Ki为5.1 nM的小鼠瑞士3T3细胞的结合[2]。Litorin刺激EC50为2.3 nM的小鼠瑞士3T3细胞中的3H-胸腺嘧啶核苷掺入[2]。
体内研究	利托林刺激平滑肌收缩,刺激胃泌素、胃酸和胰腺分泌,并在体内实验中抑制营养素[2]。
参考文献	[1]. Kam Leung. ^99mTc-pGlu-Gln-Trp-Ala-Val-Gly-His-Phe-Met-NH2. Molecular Imaging and Contrast Agent Database (MICAD). 2007 Oct 1. [2]. J M Siegfried, et al. Effects of bombesin and gastrin-releasing peptide on human bronchial epithelial cells from a series of donors: individual variation and modulation by bombesin analogs. Anat Rec. 1993 May;236(1):241-7.