61-56-3

• 常用中文名：噻嗪磺胺
• 常用英文名：Sulthiame
• CAS号：61-56-3
• 分子式：C₁₀H₁₄N₂O₄S₂
• 分子量：290.35900
• 相关类别： 信号通路 代谢酶/蛋白酶 碳酸酐酶
• 发布时间：2018-03-30 08:00:00
• 更新时间：2026-07-01 22:24:12
• Sultiame 是一种 carbonic anhydrase 抑制剂,广泛用作抗癫痫药。

名称

• 中文名: 噻嗪磺胺
• 英文名: 4-(1,1-dioxothiazinan-2-yl)benzenesulfonamide
• 中文别名: 舒噻嗪; 4-(1,1-二氧代-1,2-硫代吗啉-2-基)苯磺酰胺; 乙腈中舒噻嗪; 舒噻嗪 标准品
• 英文别名: Sultiamum; Sultiame 100 μg/mL in Acetonitrile; p-(Tetrahydro-2H-1,2-thiazin-2-yl)benzenesulfonaMide Dioxide; Ospolot; 2-(p-SulfaMoylphenyl)-tetrahydro-2H-1,2-thiazine 1,1-Dioxide; SulthiaM; Conadil; Riker; Sulthiamine; SulphthiaMe; Benzenesulfonamide, 4-(tetrahydro-1,1-dioxido-2H-1,2-thiazin-2-yl); 4-(1,1-dioxido-1,2-thiazinan-2-yl)benzenesulfonamide; Sultiame in Acetonitrile; SulphenytaMe; Sulphenyltame; Inhibitor,Cbonate dehydratase,Cbonic Anhydrase,Sultiame,inhibit; Riker 594; 4-(Tetrahydro-1,1-dioxido-2H-1,2-thiazin-2-yl)benzenesulfonaMide; sultiame; SulthiaMine; Trolone; 4-(Tetrahydro-2H-1,2-thiazin-2-yl)benzenesulfonaMide S,S-Dioxide; Sultiame solution; Bayer A; SULTHIAME; Contravul; Canadil; 4-(1,1-diketothiazinan-2-yl)benzenesulfonamide; 4-(1,1-dioxo-1,2-thiazinan-2-yl)benzenesulfonamide; Elisal; Sultiam; SulphenyltaMe

物化性质

• 密度: 1.472g/cm3
• 沸点: 520.2ºC at 760 mmHg
• 分子式: C₁₀H₁₄N₂O₄S₂
• 分子量: 290.35900
• 闪点: 268.4ºC
• 精确质量: 290.03900
• PSA: 114.30000
• LogP: 3.19090
• 外观性状: 固体
• 折射率: 1.609
• 储存条件: 2-8°C，干燥

生物活性

• 描述: Sultiame 是一种 carbonic anhydrase 抑制剂,广泛用作抗癫痫药。
• 相关类别:
  信号通路 >> 代谢酶/蛋白酶 >> 碳酸酐酶
  研究领域 >> 神经疾病
• 体外研究: Sultiame(Sulthiame)是一种磺胺,它可以通过作为碳酸酐酶抑制剂在中枢神经元中产生适度的细胞内酸中毒而发挥抗癫痫活性,从而降低动作电位和癫痫样突发的频率[1]。
• 参考文献:

  [1]. Milburn-McNulty P, et al. Sulthiame add-on therapy for epilepsy. Cochrane Database Syst Rev. 2015 Oct 28;(10):CD009472.

毒性和生态

CHEMICAL IDENTIFICATION RTECS NUMBER : DB3150000 CHEMICAL NAME : Benzenesulfonamide, p-(tetrahydro-2H-1,2-thiazin-2-yl)-, dioxide CAS REGISTRY NUMBER : 61-56-3 LAST UPDATED : 199612 DATA ITEMS CITED : 6 MOLECULAR FORMULA : C10-H14-N2-O4-S2 MOLECULAR WEIGHT : 290.38 WISWESSER LINE NOTATION : T6NSWTJ AR DSZW HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : LDLo - Lowest published lethal dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Human - woman DOSE/DURATION : 400 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : ATXKA8 Archiv fuer Toxikologie. (Berlin, Fed. Rep. Ger.) V.15-31, 1954-74. For publisher information, see ARTODN. Volume(issue)/page/year: 25,229,1969 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE/DURATION : >5 gm/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: 6,383,1982 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 1650 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : 27ZQAG "Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E., and D.H. Efron, Washington, DC, 1972 Volume(issue)/page/year: -,306,1972 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 4852 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : 27ZQAG "Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E., and D.H. Efron, Washington, DC, 1972 Volume(issue)/page/year: -,306,1972 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 1668 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : 27ZQAG "Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E., and D.H. Efron, Washington, DC, 1972 Volume(issue)/page/year: -,306,1972 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rabbit DOSE/DURATION : 1 gm/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : 27ZQAG "Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E., and D.H. Efron, Washington, DC, 1972 Volume(issue)/page/year: -,306,1972

安全

• 海关编码: 2935009090

海关

海关编码	2935009090
中文概述	2935009090 其他磺（酰）胺. 增值税率:17.0% 退税率:9.0% 监管条件:无 最惠国关税:6.5% 普通关税:35.0%
申报要素	品名, 成分含量, 用途
Summary	2935009090 other sulphonamides VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:35.0%