56271-94-4

• 常用中文名：头孢呋辛钠EP杂质A
• 常用英文名：Descarbamoyl Cefuroxime
• CAS号：56271-94-4
• 分子式：C₁₅H₁₅N₃O₇S
• 分子量：381.36100
• 相关类别： 研究领域 感染
• 发布时间：2018-12-24 17:46:57
• 更新时间：2026-07-01 18:08:23
• Descarbamoyl cefuroxime 是 Cefuroxime 的降解产物。Descarbamoyl cefuroxime 是头孢菌素类抗生素合成的中间体。

名称

• 中文名: 头孢呋辛钠EP杂质A
• 英文名: 7-{[2-Furyl(methoxyimino)acetyl]amino}-3-(hydroxymethyl)-8-oxo-5- thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid
• 中文别名: 头孢呋辛去甲酰胺; 头孢呋辛A; 头孢呋辛钠有关杂质A; 头孢呋辛杂质A(头孢呋辛脱氨基甲酰基); 头孢呋辛杂质A; 脱乙酰头孢呋辛酸; 头孢呋辛钠-A; 头孢呋辛钠杂质A(头孢呋辛酯; 去氨甲酰头孢呋辛; 头孢呋辛钠杂质A(头孢呋辛酯杂质E); 头孢呋辛杂质4(头孢呋辛钠杂质A); 头孢呋辛杂质F (头孢呋辛钠-A); 去甲酰胺基顺式头孢呋辛; 原料药头孢呋辛钠 杂质A; 头孢呋辛酯杂质E; 头孢呋辛钠杂质A; 头孢呋辛杂质4(头孢呋辛SODIUM杂质A)
• 英文别名: Deacetylcefuroximeacid; Cefuroxime Sodium Impurity A (Cefuroxime Descbamoyl); Cefuroxime Impurity A (Cefuroxime Descbamoyl); Einecs -2; 7-PHENYLACETAMINO-3-CHLOROMETHYL-3-CEPHEM4-CARBOXYLIC ACID P-METHOXYBENZYL ESTER; Cefuroxime Sodium Impurity A; Cefuroxime Imp A; 3-hydroxy methyl CefuroximeQ: What is 3-hydroxy methyl Cefuroxime Q: What is the CAS Number of 3-hydroxy methyl Cefuroxime Q: What is the storage condition of 3-hydroxy methyl Cefuroxime; 7-PHENYLACETAMIDE-3-CHLOROMETHYL-CEPHALOSPORANIC ACID P-METHOXYBENZYL ESTER; [6R-[6α,7β(Z)]]-7-[2-furyl(methoxyimino)acetamido]-3-(hydroxymethyl)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-cboxylic acid; 7-{[2-Furyl(methoxyimino)acetyl]amino}-3-(hydroxymethyl)-8-oxo-5- thia-1-azabicyclo[4.2.0]oct-2-ene-2-cboxylic acid; 3-hydroxy methyl Cefuroxime; (6R,7R)-7-((Z)-2-(furan-2-yl)-2-(methoxyimino)acetamido)-3-(hydroxymethyl)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-cboxylic acid; (6R-(6alpha,7beta(Z)))-7-(2-Furyl(methoxyimino)acetamido)-3-(hydroxymethyl)-8-oxo-5-thia-1-azabicyclo(4.2.0)oct-2-ene-2-cboxylic acid; Cefuroxime Descbamoyl; GCLE:INTERMEDIATE FOR CEPHALOSPORIN; Cefuroxime Impurity 4(Cefuroxime Sodium Impurity A); Cefuroxime Impurity 1/Cefuroxime Impurity A/Descbamoyl Cefuroxime/(6R,7R)-7-[[(Z)-(furan-2-yl)(methoxyimino)acetyl]amino]-3-(hydroxymethyl)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-cboxylic acid; Cefuroxim Sodium impurity A; [6R-[6alpha,7beta(Z)]]-7-[2-furyl(methoxyimino)acetamido]-3-(hydroxymethyl)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-cboxylic acid; (6R,7R)-7-((Z)-2-(furan-2-yl); 7-phenylacetamido-3-chloromethylcephem-4-carbonicacidp-methoxybenzylester; Cefuroxime Sodium Impurity A（Cefuroxime Axetil Impurity E）; Cefuroxime Impurity 4; 5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-cboxylicacid,7-[[(2Z)-2-(2-furanyl)-2-(methoxyimino)acetyl]amino]-3-(hydroxymethyl)-8-oxo-,(6R,7R); 7-PHENYLACETAMIDO-3-CHLOROMETHYLCEPHEM-4-CARBONICACID-PARA-METHOXYBENZYLESTER; 3-chloromethyl-7-phenylacetylaminocephalosporanic acid p-methoxybenzyl ester; Cefuroxime Impurity A; (6R,7R)-7-[[(2Z)-2-(2-Furanyl)-2-(MethoxyiMino)acetyl]amino]-3-(hydroxyMethyl)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-cboxylic Acid; (6R)-7α-[[2-Furanyl(methoxyimino)acetyl]amino]-3-hydroxymethyl-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-cboxylic acid

物化性质

• 密度: 1.72g/cm3
• 分子式: C₁₅H₁₅N₃O₇S
• 分子量: 381.36100
• 精确质量: 381.06300
• PSA: 170.46000
• LogP: 0.13920
• 折射率: 1.733

生物活性

• 描述: Descarbamoyl cefuroxime 是 Cefuroxime 的降解产物。Descarbamoyl cefuroxime 是头孢菌素类抗生素合成的中间体。
• 相关类别:
  研究领域 >> 感染
• 参考文献:

  [1]. Vercheval C, et al. Stability of 90 mg/mL cefuroxime sodium solution for administration by continuous infusion. J Chemother. 2018 Oct - Dec;30(6-8):371-374.

  [2]. Takaya T, et al. Studies on beta-lactam antibiotics. III. Synthesis and enzymatic stability of 3-acyloxymethyl-7 beta-[(Z)-2-(2-amino-4-thiazolyl)-2-(methoxyimino)acetamido]-3-cephem-4-carboxylic acids. J Antibiot (Tokyo). 1981 Oct;34(10):1300-10.

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