914613-35-7

• 常用中文名：1H-1-乙基坎地沙坦西来替昔酯
• 常用英文名：1H-1-Ethyl Candesartan Cilexetil
• CAS号：914613-35-7
• 分子式：C₃₅H₃₈N₆O₆
• 分子量：638.71300
• 相关类别： 研究领域 其他
• 发布时间：2018-12-12 19:29:21
• 更新时间：2026-07-01 21:17:50
• 1H-1-乙基坎地沙坦西雷塞替尔是坎地沙坦西雷塞梯(HY-17505)散装制剂中发现的一种潜在杂质。

名称

• 中文名: 1H-1-乙基坎地沙坦西来替昔酯
• 英文名: 1-cyclohexyloxycarbonyloxyethyl 2-ethoxy-3-[[4-[2-(1-ethyltetrazol-5-yl)phenyl]phenyl]methyl]benzimidazole-4-carboxylate
• 中文别名: 1H-N1-乙基坎地沙坦酯; 坎地沙坦 西里西替林 杂质E; 坎地沙坦酯杂质5(坎地沙坦酯杂质E); 坎地沙坦酯杂质E; 坎地沙坦西酯杂质E; CANDESTAN CILEXETIL 杂质 E; 坎地沙坦酯杂质05; 坎地沙坦酯杂质E/杂质V; 坎地沙坦环丙基1位氮乙基杂质; 坎地沙坦杂质 2; 1-[[(环己氧基)羰基]氧基]乙氧基2-乙氧基-1-[[2'-(1-乙基-1H-四唑-5-基)[1,1'-联苯]-4-基]甲基]-1H-苯并咪唑-7-羧酸盐
• 英文别名: 1H-1-Ethyl Candestan Cilexetil; Candestan Imp E; Candestan Cilexetil Impurity E (Candestan Cilexetil N1-Ethyl Analog); Candestan Impurity-E; 1-N-ethyl CNS; Candesartan Cilexetil Impurity 5; 1H-1,2,4-Triazole,1-ethyl; Candestan Cilexetil impurity E; Candestan Impurity 2; N-ethyl-1,2,4-triazole; Candestan Cilexetil Impurity EQ: What is Candestan Cilexetil Impurity E Q: What is the CAS Number of Candestan Cilexetil Impurity E Q: What is the storage condition of Candestan Cilexetil Impurity E Q: What e the applications of Candestan Cilexetil Impurity E; 1-[[(Cyclohexyloxy)carbonyl]oxy]ethyl 2-ethoxy-1-[[2′-(1-ethyl-1H-tetrazol-5-yl)[1,1′-biphenyl]-4-yl]methyl]-1H-benzimidazole-7-cboxylate; 1H-Benzimidazole-7-cboxylic acid, 2-ethoxy-1-[[2'-(1-ethyl-1H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methyl]-, 1-[[(cyclohexyloxy)carbonyl]oxy]ethyl ester; Candestan Cilexetil Impurity 5(Candestan Cilexetil Impurity E); 1-(((Cyclohexyloxy)carbonyl)oxy)ethyl 2-ethoxy-1-((2'- (1-ethyl-1H-tetrazol-5-yl)-[1,1'-biphenyl]-4-yl)methyl)- 1H-benzo[d]imidazole-7-cboxylate; 2-Ethoxy-1-[[2'-(1-ethyl-1H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methyl]- 1H-benzimidazole-7-cboxylic acid 1-[[(cyclohexyloxy)carbonyl]oxy]ethyl ester; (1RS)-1-[[(cyclohexyloxy)carbonyl]oxy]ethyl 2-ethoxy-1-[[2'-(1- ethyl-1H-tetrazol-5-yl)biphenyl-4-yl]methyl]-1H-benzimidazole-7- cboxylate; Candestan Cilexetil,1H1ethyl Candestan Cilexetil,Inhibitor,1H 1 ethyl Candestan Cilexetil,inhibit; 1-N-ethyl 1,2,4-triazole; 2-Ethoxy-1-[[2'-(1-ethyl-1H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]Methyl]; (1RS)-1-[[(Cyclohexyloxy)carbonyl]-oxy]ethyl 2-Ethoxy-1-[[2'-(1-ethyl-1H-tetrazol-5-yl)biphenyl-4-yl; 1-cyclohexyloxycbonyloxyethyl 2-ethoxy-3-[[4-[2-(1-ethyltetrazol-5-yl)phenyl]phenyl]methyl]benzimidazole-4-cboxylate; Candestan Cilexetil Imp. E : (1RS)-1-[[(cyclohexyloxy)carbonyl]oxy]ethyl 2-ethoxy- 1-[[2'-(1-ethyl-1H-tetrazol-5-yl)biphenyl-4-yl]methyl]-1H-benzimidazole-7-cboxylate; Candestan Cilexetil Impurity 5 Impurity E)

物化性质

• 分子式: C₃₅H₃₈N₆O₆
• 分子量: 638.71300
• 精确质量: 638.28500
• PSA: 132.48000
• LogP: 6.81240
• 储存条件: -20°C，密闭，干燥

生物活性

• 描述: 1H-1-乙基坎地沙坦西雷塞替尔是坎地沙坦西雷塞梯(HY-17505)散装制剂中发现的一种潜在杂质。
• 相关类别:
  研究领域 >> 其他
  信号通路 >> 其他 >> 其他

合成路线

75-03-6 145040-37-5 ~% 914613-35-7 914613-36-8

文献：Havllcek, Jaroslav; Mandelova, Zuzana; Weisemann, Ruediger; Strelec, Ivo; Placek, Lukas; Radl, Stanislav Collection of Czechoslovak Chemical Communications, 2009 , vol. 74, # 2 p. 347 - 362

145040-37-5 ~% 869631-11-8 914613-35-7 914613-36-8

文献：TEVA PHARMACEUTICAL INDUSTRIES LTD.; TEVA PHARMACEUTICALS USA, INC. Patent: WO2006/122254 A2, 2006 ; Location in patent: Page/Page column 12; 13 ;

上下游产品

上游产品  2
75-03-6 145040-37-5
下游产品  1
1185255-99-5