914613-36-8

• 常用中文名：坎地沙坦西来替昔乙酯
• 常用英文名：2H-2-Ethyl Candesartan Cilexetil
• CAS号：914613-36-8
• 分子式：C₃₅H₃₈N₆O₆
• 分子量：638.71300
• 发布时间：2018-10-15 23:38:20
• 更新时间：2026-07-08 14:10:20

名称

• 中文名: 坎地沙坦西来替昔乙酯
• 英文名: 1-cyclohexyloxycarbonyloxyethyl 2-ethoxy-3-[[4-[2-(2-ethyltetrazol-5-yl)phenyl]phenyl]methyl]benzimidazole-4-carboxylate
• 中文别名: 坎地沙坦西酯相关化合物F; 1-(((环己氧基)羰基)氧基)乙基2-乙氧基-1-((2'-(2-乙基-2H-四唑-5-基)-[1,1'-联苯]-4-基) 甲基)-1H-苯并[D]咪唑-7-羧酸盐 (坎地沙坦杂质); 1-[[(环己氧基)羰基]氧基]乙基2-乙氧基-1-[[2'-(2-乙基-2H-四唑-5-基)[1,1'-联苯]-4-基]甲基]-1H-苯并咪唑-7-羧酸盐; 2H-2-乙基坎地沙坦西来替昔酯; 坎地沙坦杂质12; 坎地沙坦酯杂质; 坎地沙坦酯杂质6(坎地沙坦酯杂质F); 坎地沙坦环丙基 2位氮乙基杂质; 坎地沙坦酯杂质F; 坎地沙坦酯杂质F(2-乙基坎地沙坦酯); 坎地沙坦酯相关物质F; 坎地沙坦酯杂质06; 坎地沙坦西酯杂质F; CANDESTAN CILEXETIL 杂质 F; 坎地沙坦杂质 4; 坎地沙坦酯杂质F/杂质VI; 坎地沙坦 西里西替林 杂质F(2-乙基坎地沙坦); 坎地沙坦酯N2-乙酯杂质; 2H-N2-乙基坎地沙坦酯
• 英文别名: 1-(((Cyclohexyloxy)carbonyl)oxy)ethyl 2-ethoxy-1-((2'- (2-ethyl-2H-tetrazol-5-yl)-[1,1'-biphenyl]-4-yl)methyl)- 1H-benzo[d]imidazole-7-cboxylate; 1H-Benzimidazole-7-cboxylic acid, 2-ethoxy-1-[[2'-(2-ethyl-2H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methyl]-, 1-[[(cyclohexyloxy)carbonyl]oxy]ethyl ester; Candestan Imp F; Candestan Impurity-F; 1-{[(cyclohexyloxy)carbonyl]oxy}ethyl 2-ethoxy-1-{[2'-(2-ethyl-2H-tetrazol-5-yl)biphenyl-4-yl]methyl}-1H-benzimidazole-7-cboxylate; Candestan Impurity 12; Candesartan Cilexetil Impurity 6; Candesartan Cilexetil EP Impurity F; 2-N-ethyl CNS; Candestan Cilexetil N2-Ethyl IMpurity; 2-Ethoxy-1-[[2'-(2-ethyl-2H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methyl]- 1H-Benzimidazole-7-cboxylic acid 1-[[(cyclohexyloxy)carbonyl]oxy]ethyl ester; Candestan Cilexetil Impurity 6 Impurity F); (1RS)-1-[[(cyclohexyloxy)carbonyl]oxy]ethyl 2-ethoxy-1- [[2′-(2-ethyl-2H-tetrazol-5-yl)biphenyl-4-yl]methyl]-1H- benzimidazole-7-cboxylate; 2H-2-Ethyl Candestan Cilexetil; Candestan Cilexetil impurity F; Candestan Cilexetil Impurity F (Candestan Cilexetil N2-Ethyl Impurity); Candestan Impurity 4; candestan cilexetil impurity1366; 2-Ethoxy-1-[[2'-[2-ethyl-1H-tetrazol-5-yl][1,1'-biphenyl]-4-yl]methyl]-1H-benzimidazole-7-cboxylic acid 1-[[(cyclohexyloxy) carbonyl]oxy]ethyl ester; Candestan Cilexetil Impurity F (2-Ethyl-Candestan Cilexetil); 2-Ethoxy-1-[[2'-(2-ethyl-2H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methyl]-1H-benzimidazole-7-carboxylic Acid 1-[[(Cyclohexyloxy)carbonyl]oxy]ethyl Ester; 1-{[(cyclohexyloxy)carbonyl]oxy}ethyl 2-ethoxy-1-{[2'-(2-ethyl-2H-tetrazol-5-yl)biphenyl-4-yl]methyl}-1H-benzimidazole-7-carboxylate; UNII-ZRT0P1L622; Candestan Cilexetil Related Compound F; 1-cyclohexyloxycbonyloxyethyl 2-ethoxy-3-[[4-[2-(2-ethyltetrazol-5-yl)phenyl]phenyl]methyl]benzimidazole-4-cboxylate; ±1-(Cyclohexyloxycarbonyloxy)ethyl2-ethoxy-1-{[2’-(N-ethyl-tetrazol-5-yl) biphenyl-4-yl]methyl}benzimidazole-7-carboxylate; 1-(((Cyclohexyloxy)carbonyl)oxy)ethyl 2-ethoxy-1-((2'-(2-ethyl-2H-tetrazol-5-yl)-[1,1'-biphenyl]-4-yl)methyl)-1H-benzo[d]imidazole-7-cboxylate (Candestan Impurity); (1RS)-1-[[(Cyclohexyloxy)carbonyl]-oxy]ethyl 2-Ethoxy-1-[[2'-(2-ethyl-2H-tetrazol-5-yl)-biphenyl-4-y; Candestan Cilexetil Impurity 6(Candestan Cilexetil Impurity F)

物化性质

• 密度: 1.3±0.1 g/cm3
• 沸点: 842.0±75.0 °C at 760 mmHg
• 分子式: C₃₅H₃₈N₆O₆
• 分子量: 638.71300
• 闪点: 463.1±37.1 °C
• 精确质量: 638.28500
• PSA: 132.48000
• LogP: 8.08
• 蒸汽压: 0.0±3.1 mmHg at 25°C
• 折射率: 1.648

安全

• 危险品运输编码: NONH for all modes of transport

合成路线

145040-37-5 ~% 869631-11-8 914613-36-8

文献：TEVA PHARMACEUTICAL INDUSTRIES LTD.; TEVA PHARMACEUTICALS USA, INC. Patent: WO2006/122254 A2, 2006 ; Location in patent: Page/Page column 12; 13 ;

75-03-6 145040-37-5 ~% 914613-35-7 914613-36-8

文献：Havllcek, Jaroslav; Mandelova, Zuzana; Weisemann, Ruediger; Strelec, Ivo; Placek, Lukas; Radl, Stanislav Collection of Czechoslovak Chemical Communications, 2009 , vol. 74, # 2 p. 347 - 362

145040-37-5 ~% 869631-11-8 914613-35-7 914613-36-8

文献：TEVA PHARMACEUTICAL INDUSTRIES LTD.; TEVA PHARMACEUTICALS USA, INC. Patent: WO2006/122254 A2, 2006 ; Location in patent: Page/Page column 12; 13 ;