163380-16-3

• 常用中文名：依折麦布(3R)-异构体
• 常用英文名：(R)-Ezetimibe
• CAS号：163380-16-3
• 分子式：C₂₄H₂₁F₂NO₃
• 分子量：409.425
• 发布时间：2017-02-13 11:08:11
• 更新时间：2026-07-06 19:49:11

名称

• 中文名: 依折麦布(3R)-异构体
• 英文名: (4S)-1-(4-fluorophenyl)-3-[(3R)-3-(4-fluorophenyl)-3-hydroxypropyl]-4-(4-hydroxyphenyl)azetidin-2-one
• 中文别名: (3'R)-埃泽蒂米贝; 依折麦布(RRS)异构体(依折麦布杂质4); 依泽替米贝(RRS)-异构体; (R)-依泽替米贝; 依折麦布杂质11(RRS); (3R,4S)-1-(4-氟苯基)-3 - ((R)-3-(4-氟苯基)-3-羟基丙基)-4-(4-羟基苯基)氮杂环丁烷-2-酮; R,R,S-依折麦布; 依折麦布(3R,4S,3R)异构体; RRS型依折麦布; 1-(4-氟苯基-(3R-[3-(4-氟苯基-(3R-羟基丙基]-(4S-(4-羟基苯基-2-丙内酰胺; (R)-伊泽替米贝; R-依折麦布; 依折麦布杂质K; 依折麦布杂质RRS; 甲基取代依折麦布杂质K; 依折麦布左旋异构体; (3'R)-依折麦布; 依折麦布-3R
• 英文别名: (3R,4S)-1-(4-Fluorophenyl)-3-[(3R)-3-(4-fluorophenyl)-3-hydroxypropyl]-4-(4-hydroxyphenyl)-2-azetidinone; Ezetimibe (RRS) Isomersy; (3′R)-Ezetimibe; (R)-EzetiMibe; Ezetimibe Impurity 11(RRS); Ezetimibe Impurity 2; RRS-EzetimibeQ: What is RRS-Ezetimibe Q: What is the CAS Number of RRS-Ezetimibe Q: What is the storage condition of RRS-Ezetimibe Q: What e the applications of RRS-Ezetimibe; Ezetimibe-23; Ezetimibe Intermediate Impurity K; (3R,4S)-1-(4-Fluorophenyl)-3-[(3R)-3-(4-fluorophenyl)-3-hydroxypropyl]-4-(4-hydroxyphenyl)-2-azetidi; 2-Azetidinone, 1-(4-fluorophenyl)-3-[(3R)-3-(4-fluorophenyl)-3-hydroxypropyl]-4-(4-hydroxyphenyl)-, (3R,4S); Ezetimibe impurity RRS; (3'R)-Ezetimibe; Ezetimibe impurities 4; (3’R)-Ezetimibe;(3R,4S)-1-(4-Fluorophenyl)-3-[(3R)-3-(4-fluorophenyl)-3-hydroxypropyl]-4-(4-hydroxyphenyl)-2-azetidinone;EzetiMibe (3R)-IsoMer;(R)-EzetiMibe; Ezetimibe (3R,4S,3R)-Isome; Ezetimibe Impurity K; Ezetimibe Impurity G ((3'R)-Ezetimibe); 1-(4-Fluorophenyl)-3-[3-(4-fluorophenyl)-3-hydroxypropyl]-4-(4-hydroxyphenyl)azetidin-2-one; Ezetimibe impuriry 4/(3’R)-Ezetimibe/(3R,4S)-1-(4-fluorophenyl)-3-((R)-3-(4-fluorophenyl)-3-hydroxypropyl)-4-(4-hydroxyphenyl)azetidin-2-one; EzetiMibe (3R)-IsoMer; (3R,4S)-1-(4-fluorophenyl)-3-((R)-3-(4-fluorophenyl)-3-hydroxypropyl)-4-(4-hydroxyphenyl)azetidin-2-one; 1-(4-Fluorophenyl)-3-[3-(4-fluorophenyl)-3-hydroxypropyl]-4-(4-hydroxyphenyl)-2-azetidinone; R,R,S-Ezetimibed; (3R,4S)-1-(4-fluorophenyl)-3-[(3R)-3-(4-fluorophenyl)-3-hydroxypropyl]-4-(4-hydroxyphenyl)azetidin-2-one; (3R,4R,3’ (3’R)-Ezetimibe; (3R,4S)-1-(4-Fluorophenyl)-3-[(3R)-3-(4-fluorophenyl)-3-hydroxypropyl]-4-(4-hydroxyphenyl)-2-azetidinone ((3'R)-Ezetimibe)

物化性质

• 密度: 1.3±0.1 g/cm3
• 沸点: 654.9±55.0 °C at 760 mmHg
• 分子式: C₂₄H₂₁F₂NO₃
• 分子量: 409.425
• 闪点: 349.9±31.5 °C
• 精确质量: 409.148956
• PSA: 60.77000
• LogP: 3.26
• 蒸汽压: 0.0±2.1 mmHg at 25°C
• 折射率: 1.624

合成路线

191330-56-0 ~% 163222-33-1 163380-16-3

文献：US2006/69080 A1, ; Page/Page column 27 ;

190595-65-4 ~% 163222-33-1 163380-16-3

文献：US2005/96307 A1, ; Page/Page column 24 ;

163380-15-2 ~% 163380-16-3

文献：Journal of Medicinal Chemistry, , vol. 41, # 6 p. 973 - 980

219653-96-0 ~% 163380-16-3

文献：Journal of Medicinal Chemistry, , vol. 41, # 6 p. 973 - 980

204589-82-2 ~% 163380-16-3

文献：Journal of Medicinal Chemistry, , vol. 41, # 6 p. 973 - 980

204589-84-4 ~% 163380-16-3

文献：Journal of Medicinal Chemistry, , vol. 41, # 6 p. 973 - 980

190595-65-4 ~% 163380-16-3

文献：Journal of Medicinal Chemistry, , vol. 41, # 6 p. 973 - 980

204589-80-0 ~% 163380-16-3

文献：Journal of Medicinal Chemistry, , vol. 41, # 6 p. 973 - 980

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