193281-00-4

• 常用中文名：培美曲塞6-氧基二酸杂质
• 常用英文名：LY 338979
• CAS号：193281-00-4
• 分子式：C₂₀H₂₁N₅O₇
• 分子量：443.41
• 相关类别： 医药中间体 OLED材料中间体
• 发布时间：2017-10-03 01:42:21
• 更新时间：2026-07-16 22:25:49
• LY-338979(培美曲塞6-氧代二酸杂质)是LY231514(培美曲塞；HY-10820)的代谢产物[1]。

名称

• 中文名: 培美曲塞6-氧基二酸杂质
• 英文名: (2R)-2-[[4-[2-(2-amino-4,6-dioxo-5,7-dihydro-1H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl]benzoyl]amino]pentanedioic acid
• 中文别名: 培美曲塞6-氧二酸杂质; 培美曲塞酮杂质; 培美曲塞氧化杂质1; 培美曲塞氧化杂质; 培美曲塞二钠-6-氧代杂质(游离酸); 培美曲塞杂质P010008; 培美曲塞杂质15 (非对映体混合物); 培美曲塞6-氧化杂质; 培美曲塞6-OXO二酸杂质; 培美曲塞钠杂质; 培美曲塞钠杂质7; 培美曲塞氧化降解杂质
• 英文别名: N-[4-[2-(2-Amino-4,5,6,7-tetrahydro-4,6-dioxo-1H-pyrrolo[2,3-d]pyriMidin-5-yl)ethyl]benzoyl]-L-glutaMic Acid ISO 9001：2015 REACH; N-[4-[2-(2-Amino-4,5,6,7-tetrahydro-4,6-dioxo-1H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl]benzoyl]-L-glutamic Acid; Pemetrexed Impurity 15 (Mixture of Diastereomers); L-Glutamic acid, N-[4-[2-(2-amino-4,5,6,7-tetrahydro-4,6-dioxo-1H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl]benzoyl]- (9CI); Pemetrexed disodium Impurity 11; PeMetrexed IMpurity (Mixture of DiastereoMers) (N-[4-[2-(2-Amino-4,5,6,7-tetrahydro-4,6-dioxo-1H-pyrrolo[2.3-d]-pyriMidi; Pemetrexed 6-Oxo Diacid Impurity (keto pemetrexed); Pemetrexed Keto impurity (Mixture of isomers); Pemetrexed Impurity 18; Pemetrexed Keto impurity; Pemetrexed -6-oxo-Impurity D; Pemetrexed impurity 7/Pemetrexed Keto impurity/(4-(2-(2-amino-4,6-dioxo-4,5,6,7-tetrahydro-3H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl)benzoyl)-L-glutamic acid; Pemetrexed 6-oxic acid impurity; 2-{4-[2-(2-amino-4,6-dioxo-4,5,6,7-tetrahydro-3H-pyrrolo[2,3-d]pyrimidin-5-yl)-ethyl]-benzoylamino}-pentanedioic acid; (2R)-2-[[4-[2-(2-amino-4,6-dioxo-5,7-dihydro-1H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl]benzoyl]amino]pentanedioicaci; Pemetrexed Sodium Impurity 7; Noradrenaline Impurity 53; N-[4-[2-(2-Amino-4,5,6,7-tetrahydro-4,6-dioxo-1H-pyrrolo[2,3-d]pyriMidin-5-yl)ethyl]benzoyl]-L-glutaMic Acid; Pemetrexed 6-Oxo Diacid Impurity; Pemetrexed impurities 7; (2S)-2-(4-(2-(2-amino-4,6-dioxo-4,5,6,7-tetrahydro-1H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl)benzamido)pentanedioic acid

物化性质

• 分子式: C₂₀H₂₁N₅O₇
• 分子量: 443.41
• 精确质量: 443.14400
• PSA: 209.05000
• LogP: 0.88680

生物活性

• 描述: LY-338979(培美曲塞6-氧代二酸杂质)是LY231514(培美曲塞；HY-10820)的代谢产物[1]。
• 相关类别:
  研究领域 >> 癌症
• 参考文献:

  [1]. Woodland JM, et al. Metabolism and disposition of the antifolate LY231514 in mice and dogs. Drug Metab Dispos. 1997 Jun;25(6):693-700.

合成路线

1320346-37-9 ~% 193281-00-4

文献：Sekhar; Acharyulu, Palle V.R.; Anjaneyulu, Yerramilli Tetrahedron Letters, 2011 , vol. 52, # 32 p. 4140 - 4144

193265-47-3 ~% 193281-00-4

文献：Sekhar; Acharyulu, Palle V.R.; Anjaneyulu, Yerramilli Tetrahedron Letters, 2011 , vol. 52, # 32 p. 4140 - 4144

106200-41-3 ~% 193281-00-4

文献：Sekhar; Acharyulu, Palle V.R.; Anjaneyulu, Yerramilli Tetrahedron Letters, 2011 , vol. 52, # 32 p. 4140 - 4144

1320346-43-7 ~% 193281-00-4

文献：Sekhar; Acharyulu, Palle V.R.; Anjaneyulu, Yerramilli Tetrahedron Letters, 2011 , vol. 52, # 32 p. 4140 - 4144

619-42-1 ~% 193281-00-4

文献：Sekhar; Acharyulu, Palle V.R.; Anjaneyulu, Yerramilli Tetrahedron Letters, 2011 , vol. 52, # 32 p. 4140 - 4144