863031-24-7

• 常用中文名：阿齐沙坦酯钾盐
• 常用英文名：azilsartan kamedoxomil
• CAS号：863031-24-7
• 分子式：C₃₀H₂₃KN₄O₈
• 分子量：606.62
• 相关类别： 信号通路 G 蛋白偶联受体/G 蛋白 血管紧张素受体
• 发布时间：2018-08-23 18:57:32
• 更新时间：2026-07-01 15:24:22
• Azilsartan酯(TAK 491)磷酸二氢钾是口服活性的1型血管紧张素II受体拮抗剂,IC50为0.62 nM。

名称

• 中文名: 阿齐沙坦酯钾盐
• 英文名: azilsartan kamedoxomil
• 中文别名: 阿齐沙坦酯钾盐AZILSTANKAMEDOXOMIL(WITH5INTS.); 阿齐沙坦/阿奇沙坦酯衍生物; 阿齐沙坦杂质; 阿齐沙坦杂质60 钾盐; 美阿沙坦钾原料药(阿齐沙坦酯钾盐); 美阿沙坦钾; 阿齐沙坦酯钾; 阿齐沙坦酯磷酸二氢钾; 阿齐沙坦杂质31; 阿齐沙坦/阿奇沙坦酯钾盐; 美阿沙坦钾 Azilstan Medoxomil Potassium; 阿奇沙坦酯钾盐; 阿齐沙坦酯钾盐杂质; 阿齐沙坦杂质45 钾盐; 阿齐沙坦酯衍生物; 美阿沙坦钾及中间体、杂质; 3-(4'-((2-乙氧基-7-(((5-甲基-2-氧代-1,3-二氧杂环戊二烯-4-基)甲氧基)羰基)-1H-苯并[d]咪唑-1-基)甲基)-[1,1'-联苯基]-2-基)-5-氧代-5H-1,2,4-恶二唑-2-钾盐; 3-(4'-((2-乙氧基-7-(((5-甲基-2-氧代-1,3-二氧杂环戊二烯-4-基)甲氧基)羰基)-1H-苯并[D]咪唑-1-基)甲基)-[1,1'-联苯基]-2-基)-5-氧代-5H-1,2,4-恶二唑-2-钾盐; 阿齐沙坦酯甲盐; 阿齐沙坦杂质50(钾盐); 美阿沙坦钾(阿齐沙坦酯钾)
• 英文别名: UNII-WEC6I2K1FC; Azilstan MedoxoMil PotassiuM salt; Azilstan Impurity 50 Potassium Salt; Azilstan MedoxoMil (MonopotassiuM); Azilstan Mehtyl ester; Azilstan kaMedoxoMil; 1-[[2'-(2,5-Dihydro-5-oxo-1,2,4-oxadiazol-3-yl)[1,1'-biphenyl]-4-yl]methyl]-2-ethoxy-1H-benzimidazole-7-cboxylic acid (5-methyl-2-oxo-1,3-dioxol-4-yl)methyl ester potassium salt; TAK 491 kamedoxomil; TAK-491; Azilsartan (medoxomil monopotassium); Potassium 3-(4'-((2-ethoxy-7-(((5-methyl-2-oxo-1,3-dioxol-4-yl)methoxy)carbonyl)-1H-benzo[d]imidazol-1-yl)methyl)-[1,1'-biphenyl]-2-yl)-5-oxo-5H-1,2,4-oxadiazol-2-ide; Azilstan medoxomil monopotassium; Azilstan KaModoxoMil; Azilstan Medoxomil Potassium; TAK-491 monopotassium; Azilstan kaMedoxoMil (with 5 ints.); Azilstan MedoxMil PotassuiM; (5-Methyl-2-oxo-[1,3]dioxol-4-yl)methyl 2-ethoxy-1-((2'-(5-oxo-4,5-dihydro-1,2,4-oxadiazol-3-yl)-biphenyl-4-yl)methyl)-1H-benzo[d]imidazol-7-cboxylate, potassium salt; AZILSTAN KAMEDOXOMIL IH; (5-methyl-2-oxo-1,3-dioxol-4-yl)methyl 2-ethoxy-1-((2'-(5-oxo-4,5-dihydro-1,2,4-oxadiazol-3-yl)-[1,1'-biphenyl]-4-yl)methyl)-1H-benzo[d]imidazole-7-cboxylate, potassium salt; Azilstan Impurity 45 Potassium Salt; Potassium 3-{4'-[(2-ethoxy-7-{[(5-methyl-2-oxo-1,3-dioxol-4-yl)methoxy]carbonyl}-1H-benzimidazol-1-yl)methyl]-2-biphenylyl}-5-oxo-1,2,4-oxadiazol-4-ide; Azilsartan kamedoxomil (USAN); Azilstan MedoxoMil (MonopotassiuM salt); Azilstan MedoxiMil PotassiuM; 1H-Benzimidazole-7-carboxylic acid, 1-[[2'-(4,5-dihydro-5-oxo-1,2,4-oxadiazol-3-yl)[1,1'-biphenyl]-4-yl]methyl]-2-ethoxy-, (5-methyl-2-oxo-1,3-dioxol-4-yl)methyl ester, potassium salt (1:1); Azilstan Impurity 60 Potassium Salt; 1H-BenziMidazole-7-cboxylic acid, 1-[[2'-(2,5-dihydro-5-oxo-1,2,4-oxadiazol-3-yl)[1,1'-biphenyl]-4-yl]Methyl] -2-ethoxy-, (5-Methyl-2-oxo-1,3-dioxol-4-yl)Methyl ester, potassiuM salt; Azilsartan medoxomil monopotassium; WEC6I2K1FC; Azilstan Medoxomil Potassium Crude; potassium,(5-methyl-2-oxo-1,3-dioxol-4-yl)methyl 2-ethoxy-3-[[4-[2-(5-oxo-1-oxa-2-aza-4-azanidacyclopent-2-en-3-yl)phenyl]phenyl]methyl]benzimidazole-4-carboxylate; Azilstan KaMedoximil

物化性质

• 分子式: C₃₀H₂₃KN₄O₈
• 分子量: 606.62
• PSA: 155.59000
• LogP: 4.70520
• 储存条件: 2-8℃

生物活性

• 描述: Azilsartan酯(TAK 491)磷酸二氢钾是口服活性的1型血管紧张素II受体拮抗剂,IC50为0.62 nM。
• 相关类别:
  信号通路 >> G 蛋白偶联受体/G 蛋白 >> 血管紧张素受体
  研究领域 >> 心血管疾病
• 参考文献:

  [1]. Kajiya T, Ho C, Wang J, Molecular and cellular effects of azilsartan: a new generation angiotensin II receptor blocker. J Hypertens. 2011 Dec;29(12):2476-83.

  [2]. Kusumoto K, Igata H, Ojima M, Antihypertensive, insulin-sensitising and renoprotective effects of a novel, potent and long-acting angiotensin II type 1 receptor blocker, azilsartan medoxomil, in rat and dog models.

  [3]. Perry CM. Azilsartan medoxomil: a review of its use in hypertension. Clin Drug Investig. 2012 Sep 1;32(9):621-39.

  [4]. Pierini D, Anderson KV. Azilsartan medoxomil/chlorthalidone: a new fixed-dose combination antihypertensive. Ann Pharmacother. 2013 May;47(5):694-703.