阿齐沙坦酯钾盐

更新时间：2025-08-25 10:33:57

阿齐沙坦酯钾盐结构式	常用名	阿齐沙坦酯钾盐	英文名	azilsartan kamedoxomil
	CAS号	863031-24-7	分子量	606.62
	密度	N/A	沸点	N/A
	分子式	C₃₀H₂₃KN₄O₈	熔点	N/A
	MSDS	N/A	闪点	N/A

阿齐沙坦酯钾盐用途

Azilsartan酯(TAK 491)磷酸二氢钾是口服活性的1型血管紧张素II受体拮抗剂,IC50为0.62 nM。

中文名	阿齐沙坦酯钾盐
英文名	azilsartan kamedoxomil
英文别名	更多

描述	Azilsartan酯(TAK 491)磷酸二氢钾是口服活性的1型血管紧张素II受体拮抗剂,IC50为0.62 nM。
相关类别	信号通路 >> G 蛋白偶联受体/G 蛋白 >> 血管紧张素受体研究领域 >> 心血管疾病
参考文献	[1]. Kajiya T, Ho C, Wang J, Molecular and cellular effects of azilsartan: a new generation angiotensin II receptor blocker. J Hypertens. 2011 Dec;29(12):2476-83. [2]. Kusumoto K, Igata H, Ojima M, Antihypertensive, insulin-sensitising and renoprotective effects of a novel, potent and long-acting angiotensin II type 1 receptor blocker, azilsartan medoxomil, in rat and dog models. [3]. Perry CM. Azilsartan medoxomil: a review of its use in hypertension. Clin Drug Investig. 2012 Sep 1;32(9):621-39. [4]. Pierini D, Anderson KV. Azilsartan medoxomil/chlorthalidone: a new fixed-dose combination antihypertensive. Ann Pharmacother. 2013 May;47(5):694-703.

描述

Azilsartan酯(TAK 491)磷酸二氢钾是口服活性的1型血管紧张素II受体拮抗剂,IC50为0.62 nM。

相关类别

信号通路 >> G 蛋白偶联受体/G 蛋白 >> 血管紧张素受体

研究领域 >> 心血管疾病

参考文献

[1]. Kajiya T, Ho C, Wang J, Molecular and cellular effects of azilsartan: a new generation angiotensin II receptor blocker. J Hypertens. 2011 Dec;29(12):2476-83.

[2]. Kusumoto K, Igata H, Ojima M, Antihypertensive, insulin-sensitising and renoprotective effects of a novel, potent and long-acting angiotensin II type 1 receptor blocker, azilsartan medoxomil, in rat and dog models.

[3]. Perry CM. Azilsartan medoxomil: a review of its use in hypertension. Clin Drug Investig. 2012 Sep 1;32(9):621-39.

[4]. Pierini D, Anderson KV. Azilsartan medoxomil/chlorthalidone: a new fixed-dose combination antihypertensive. Ann Pharmacother. 2013 May;47(5):694-703.

分子式	C₃₀H₂₃KN₄O₈
分子量	606.62
PSA	155.59000
LogP	4.70520
InChIKey	IHWFKDWIUSZLCJ-UHFFFAOYSA-M
SMILES	CCOc1nc2cccc(C(=O)OCc3oc(=O)oc3C)c2n1Cc1ccc(-c2ccccc2-c2noc(=O)[n-]2)cc1.[K+]
储存条件	2-8℃

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来源：24386
靶标：N/A
External Id：Sarm1 Tir NADase inhibitors screen

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来源：ChEMBL
靶标：Severe acute respiratory syndrome coronavirus 2
External Id：CHEMBL4513082

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靶标：Severe acute respiratory syndrome coronavirus 2
External Id：CHEMBL4303805

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靶标：Replicase polyprotein 1ab
External Id：CHEMBL4495582

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UNII-WEC6I2K1FC

TAK-491

Azilsartan medoxomil monopotassium

WEC6I2K1FC

azilsartan kamedoxomil

Potassium 3-{4'-[(2-ethoxy-7-{[(5-methyl-2-oxo-1,3-dioxol-4-yl)methoxy]carbonyl}-1H-benzimidazol-1-yl)methyl]-2-biphenylyl}-5-oxo-1,2,4-oxadiazol-4-ide

potassium,(5-methyl-2-oxo-1,3-dioxol-4-yl)methyl 2-ethoxy-3-[[4-[2-(5-oxo-1-oxa-2-aza-4-azanidacyclopent-2-en-3-yl)phenyl]phenyl]methyl]benzimidazole-4-carboxylate

Azilsartan kamedoxomil (USAN)

1H-Benzimidazole-7-carboxylic acid, 1-[[2'-(4,5-dihydro-5-oxo-1,2,4-oxadiazol-3-yl)[1,1'-biphenyl]-4-yl]methyl]-2-ethoxy-, (5-methyl-2-oxo-1,3-dioxol-4-yl)methyl ester, potassium salt (1:1)

Azilsartan (medoxomil monopotassium)