3258-02-4

• 常用中文名：Beta-d-N4-hydroxycytidine
• 常用英文名：Beta-d-N4-hydroxycytidine
• CAS号：3258-02-4
• 分子式：C₉H₁₃N₃O₆
• 分子量：259.21600
• 相关类别： 研究领域 感染
• 发布时间：2016-04-10 13:23:51
• 更新时间：2026-07-01 06:27:47
• Beta-d-N4-hydroxycytidine 是一种非常有效的抗委内瑞拉马脑炎病毒剂 (anti-VEEV) ,EC50, EC90 和 EC99 分别为 0.426,1.036 和 2.5 μM。

名称

• 中文名: 1-((2R,3R,4S,5R)-3,4-二羟基-5-(羟甲基)四氢呋喃-2-基)-4-(羟基亚氨基)-3,4-二氢嘧啶-2(1H)-酮
• 英文名: 1-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-4-(hydroxyamino)pyrimidin-2-one
• 中文别名: N-羟基胞苷; N4-羟基胞苷; 莫匹拉韦中间体EIDD-1931; 莫努匹韦杂质 1; 5'-O-异丁酰基尿苷; 1-((2R,3R,4S,5R)-3,4-二羟基-5-(羟甲基)四氢呋喃-2-基)-4-(肟基)-3,4-二氢嘧啶-2(1H)-酮; 莫诺拉韦杂质A; EIDD-1931试剂; EIDD-1931 化学试剂; EIDD-1931 N-羟基胞苷; 1-((2R,3R,4S,5R)-3,4-二羟基-5-(羟甲基)四氢呋喃-2-基)-4-(羟基亚氨基)-3,4-二氢嘧啶-2(1H)-酮 (莫钠皮拉韦杂质); 孟努匹拉韦杂质1; 莫努匹韦杂质; N-羟基胞苷(NHC); 莫那比拉韦杂质1; 莫那匹韦杂质1; 1-[(2R,3R,4S,5R)-3,4-二羟基-5-(羟基甲基)四氢呋喃-2-基]-4-(羟基氨基)嘧啶-2-酮; 莫那比拉韦杂质B/N-羟基胞苷; 莫匹拉韦中EIDD-1931; N-羟基胞苷(NHC(EIDD-1931))
• 英文别名: N-Hydroxycytidine; Molnupiravir Impurity A/N-hydroxycytidine; N4-Hydroxycytidine (NHC); Uridine,4-oxime; 0/4/58; Cytidine,N-hydroxy; EIDD 2801-metabolit; EIDD-1931 (Beta-d-N4-hydroxycytidine; Uridine, 4-oxime; EIDD-193; EIDD2801 ,β-D-N4-hydroxycytidine; 4-N-Hydroxycytidine; N-Hydroxycytidine (EIDD-1931) for cell culture Endotoxin (BET) 0.05EU/mg; β-D-N4-Hydroxycytidine; Engagliflozin; Molnupiravir Impurity 1; 1-((2R,3R,4S,5R)-3,4-Dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-4-(hydroxyimino)-3,4-dihydropyrimidin-2(1H)-one (Molnupiravir Impurity); Monovir impurity A; Chikungunya,equine,Enterovirus,HEV,EIDD 1931,HRV,Hatitis C virus,Inhibitor,EIDD1931,CHIKV,Topoisomerase,Enterovirus,VEEV,HEVs,NHC,Rhinovirus,HCV,enchalitis,SS-CoV,EIDD-1931,inhibit,venezuelan,HRVs,SS coronavirus; EIDD-1931; 13C,15N3]-2'-Deoxycytidine; 1-[(2R,3R,4S,5R)-3,4-Dihydroxy-5-(Hydroxymethyl)Oxolan-2-Yl]-4-(Hydroxyamino)Pyrimidin-2-One; Monabiravir impurity 1; EIDD 1931 - Bio-X; N(4)-hydroxycytidine; EIDD-2801-metabolite; Beta-d-N4-hydroxycytidine (NHC); 1-((2R,3R,4S,5R)-3,4-Dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-4-(hydroxyimino)-3,4-dihydropyrimidin-2(1H)-oneQ: What is 1-((2R,3R,4S,5R)-3,4-Dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-4-(hydroxyimino)-3,4-dihydropyrimidin-2(1H)-one Q: What is the CAS Number of 1-((2R,3R,4S,5R)-3,4-Dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-4-(hydroxyimino)-3,4-dihydropyrimidin-2(1H)-one Q: What is the storage condition of 1-((2R,3R,4S,5R)-3,4-Dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-4-(hydroxyimino)-3,4-dihydropyrimidin-2(1H)-one; EIDD2801-metabolite; 3,4-Dihydro-1-β-D-ribofuranosyl-4-(hydroxyimino)pyrimidin-2(1H)-one; N4-Hydroxycytidine; 1-[(2R)-3α,4α-Dihydroxy-5β-(hydroxymethyl)oxolane-2β-yl]-4-(hydroxyamino)pyrimidine-2(1H)-one

物化性质

• 分子式: C₉H₁₃N₃O₆
• 分子量: 259.21600
• 精确质量: 259.08000
• PSA: 137.07000
• 外观性状: 固体;White to Light yellow powder to crystal
• 储存条件: -20°C;存放于惰性气体之中;避免空气,湿气 (吸湿),加热

生物活性

• 描述: Beta-d-N4-hydroxycytidine 是一种非常有效的抗委内瑞拉马脑炎病毒剂 (anti-VEEV) ,EC50, EC90 和 EC99 分别为 0.426,1.036 和 2.5 μM。
• 相关类别:
  研究领域 >> 感染
  信号通路 >> 其他 >> 其他
• 参考文献:

  [1]. Urakova N, et al. β-d-N⁴-Hydroxycytidine Is a Potent Anti-alphavirus Compound That Induces a High Level of Mutations in the Viral Genome. J Virol. 2018 Jan 17;92(3). pii: e01965-17.

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