1248-42-6

• 常用中文名：盐酸匹敌威
• 常用英文名：Pitofenone hydrochloride
• CAS号：1248-42-6
• 分子式：C₂₂H₂₆ClNO₄
• 分子量：403.89900
• 相关类别： 信号通路 神经信号通路 疼痛
• 发布时间：2016-12-02 14:04:59
• 更新时间：2024-03-03 14:09:51
• Pitofenone hydrochloride 是一种解痉化合物,能够抑制乙酰胆碱酯酶 (AChE) 的活性,对于来自牛红细胞和电鳗的乙酰胆碱酯酶的 Ki 值分别为 36 和 45 μM。

名称

• 中文名: 盐酸匹敌威
• 英文名: methyl 2-[4-[2-piperidinoethoxy]benzoyl]benzoate hydrochloride
• 英文别名: 2-[4-(2-Piperidino-aethoxy)-benzoyl]-benzoesaeure-methylester,Hydrochlorid; methyl 2-[4-(2-piperidin-1-ylethoxy)benzoyl]benzoate hydrochloride; 2-[4-(2-piperidino-ethoxy)-benzoyl]-benzoic acid methyl ester,hydrochloride; pitofenone hydrochloride; methyl 2-[4-(2-piperidin-1-ylethoxy)phenyl]carbonylbenzoate hydrochloride; methyl 2-[4-(2-piperidinoethoxy)benzoyl]benzoate hydrochloride

物化性质

• 沸点: 512ºC at 760 mmHg
• 分子式: C₂₂H₂₆ClNO₄
• 分子量: 403.89900
• 闪点: 263.4ºC
• 精确质量: 403.15500
• PSA: 55.84000
• LogP: 4.30880
• 蒸汽压: 1.35E-10mmHg at 25°C
• 储存条件: 2-8℃

生物活性

• 描述: Pitofenone hydrochloride 是一种解痉化合物,能够抑制乙酰胆碱酯酶 (AChE) 的活性,对于来自牛红细胞和电鳗的乙酰胆碱酯酶的 Ki 值分别为 36 和 45 μM。
• 相关类别:
  信号通路 >> 神经信号通路 >> 疼痛
  研究领域 >> 神经疾病
• 靶点:

  Ki: 36 μM (AChE, bovine erythrocytes), 45 μM (AChE, electric eel)

• 参考文献:

  [1]. Punekar NS, et al. Acetylcholinesterase inhibition by pitofenone: a spasmolytic compound. Biotechnol Appl Biochem. 1991 Dec;14(3):378-82.

毒性和生态

CHEMICAL IDENTIFICATION RTECS NUMBER : DH6477800 CHEMICAL NAME : Benzoic acid, o-(p-(2-piperidinoethoxy)benzoyl)-, methyl ester, hydrochloride CAS REGISTRY NUMBER : 1248-42-6 LAST UPDATED : 198912 DATA ITEMS CITED : 4 MOLECULAR FORMULA : C22-H25-N-O4.Cl-H HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 3600 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : TKZGAG Trudove na Nauchnoizsledovatelskiya Khimiko-Farmatsevtichen Institut. Transactions of the Scientific Research Chemico-Pharmaceutical Institute. (Durzhavno Izdatelstvo Tekhnika, Bul. Russki 6, Sofia Bulgaria) V.4- 1963 Volume(issue)/page/year: 15,211,1985 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 125 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : TKZGAG Trudove na Nauchnoizsledovatelskiya Khimiko-Farmatsevtichen Institut. Transactions of the Scientific Research Chemico-Pharmaceutical Institute. (Durzhavno Izdatelstvo Tekhnika, Bul. Russki 6, Sofia Bulgaria) V.4- 1963 Volume(issue)/page/year: 15,211,1985 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 690 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : TKZGAG Trudove na Nauchnoizsledovatelskiya Khimiko-Farmatsevtichen Institut. Transactions of the Scientific Research Chemico-Pharmaceutical Institute. (Durzhavno Izdatelstvo Tekhnika, Bul. Russki 6, Sofia Bulgaria) V.4- 1963 Volume(issue)/page/year: 15,211,1985 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 150 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : TKZGAG Trudove na Nauchnoizsledovatelskiya Khimiko-Farmatsevtichen Institut. Transactions of the Scientific Research Chemico-Pharmaceutical Institute. (Durzhavno Izdatelstvo Tekhnika, Bul. Russki 6, Sofia Bulgaria) V.4- 1963 Volume(issue)/page/year: 15,211,1985

安全

• 海关编码: 2933399090

海关

海关编码	2933399090
中文概述	2933399090. 其他结构含非稠合吡啶环的化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%
申报要素	品名, 成分含量, 用途, 乌洛托品请注明外观, 6－己内酰胺请注明外观, 签约日期
Summary	2933399090. other compounds containing an unfused pyridine ring (whether or not hydrogenated) in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%