134470-38-5

• 常用中文名：BW-B 70C
• 常用英文名：BW-B 70C
• CAS号：134470-38-5
• 分子式：C₁₇H₁₇FN₂O₃
• 分子量：316.32700
• 相关类别： 研究领域 其他
• 发布时间：2016-10-30 10:40:35
• 更新时间：2024-01-02 16:17:54
• BW B70C是一种有效、选择性和口服活性花生四烯酸5-脂氧合酶抑制剂。BW B70C抑制豚鼠吸入过敏原后的急性和过敏性支气管收缩和晚期嗜酸性粒细胞聚集。BW B70C可防止白三烯C4的合成,减少白细胞向气道腔的迁移以及白蛋白微血管渗漏。BW B70C具有抗哮喘药物研究的潜力[1][2][3]。

名称

• 英文名: bw b70c
• 英文别名: 70C; 1-[(E)-4-[3-(4-fluorophenoxy)phenyl]but-3-en-2-yl]-1-hydroxyurea; N-[3-[3-4(-Fluorophenoxy)phenyl]-1-methyl-2-propenyl]-N-hydroxyurea

物化性质

• 密度: 1.295g/cm3
• 沸点: 498.9ºC at 760 mmHg
• 分子式: C₁₇H₁₇FN₂O₃
• 分子量: 316.32700
• 闪点: 255.5ºC
• 精确质量: 316.12200
• PSA: 75.79000
• LogP: 4.48990
• 蒸汽压: 8.96E-11mmHg at 25°C
• 折射率: 1.627

生物活性

• 描述: BW B70C是一种有效、选择性和口服活性花生四烯酸5-脂氧合酶抑制剂。BW B70C抑制豚鼠吸入过敏原后的急性和过敏性支气管收缩和晚期嗜酸性粒细胞聚集。BW B70C可防止白三烯C4的合成,减少白细胞向气道腔的迁移以及白蛋白微血管渗漏。BW B70C具有抗哮喘药物研究的潜力[1][2][3]。
• 相关类别:
  研究领域 >> 其他
• 体内研究: BW B70C(30 mg/kg；i.p.)可防止肺泡巨噬细胞合成白三烯C4,并减少白细胞向气道腔的迁移以及白蛋白微血管渗漏,但不影响内毒素诱导的TNF-α和分泌型磷脂酶A2血水平的升高[2]。
• 参考文献:

  [1]. Yeadon M, et al. Effect of BW B70C, a novel inhibitor of arachidonic acid 5-lipoxygenase, on allergen-induced bronchoconstriction and late-phase lung eosinophil accumulation in sensitised guinea-pigs. Agents Actions. 1993 Jan;38(1-2):8-18.

  [2]. Bureau MF, et al. 5-Lipoxygenase and endotoxin-induced microvascular albumin exchanges and leucocyte recruitment in guinea-pig lungs. Eur J Pharmacol. 1997 Apr 11;324(1):89-98.

  [3]. Payne AN, et al. Hydroxamic acids and hydroxyureas as novel, selective 5-lipoxygenase inhibitors for possible use in asthma. Agents Actions Suppl. 1991;34:189-99.

毒性和生态

CHEMICAL IDENTIFICATION RTECS NUMBER : YT3976666 CHEMICAL NAME : Urea, N-(3-(3-(4-fluorophenoxy)phenyl)-1-methyl-2-propenyl) -N-hydroxy- CAS REGISTRY NUMBER : 134470-38-5 LAST UPDATED : 199803 DATA ITEMS CITED : 2 MOLECULAR FORMULA : C17-H17-F-N2-O3 MOLECULAR WEIGHT : 316.36 HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 700 mg/kg/14D-I TOXIC EFFECTS : Kidney, Ureter, Bladder - changes in tubules (including acute renal failure, acute tubular necrosis) Kidney, Ureter, Bladder - interstitial nephritis REFERENCE : ARTODN Archives of Toxicology. (Springer-Verlag, Heidelberger Pl. 3, D-1000 Berlin 33, Fed. Rep. Ger.) V.32- 1974- Volume(issue)/page/year: 69,480,1995 TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 700 mg/kg/7D-I TOXIC EFFECTS : Kidney, Ureter, Bladder - changes primarily in glomeruli Kidney, Ureter, Bladder - proteinuria Blood - other changes REFERENCE : TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 146,299,1997

安全

• 个人防护装备: Eyeshields;Gloves;half-mask respirator (US);multi-purpose combination respirator cartridge (US)
• 安全声明 (欧洲): S24/25
• 危险品运输编码: NONH for all modes of transport
• RTECS号: YT3976666