BW-B 70C结构式
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常用名 | BW-B 70C | 英文名 | BW-B 70C |
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CAS号 | 134470-38-5 | 分子量 | 316.32700 | |
密度 | 1.295g/cm3 | 沸点 | 498.9ºC at 760 mmHg | |
分子式 | C17H17FN2O3 | 熔点 | N/A | |
MSDS | 中文版 美版 | 闪点 | 255.5ºC |
BW-B 70C用途BW B70C是一种有效、选择性和口服活性花生四烯酸5-脂氧合酶抑制剂。BW B70C抑制豚鼠吸入过敏原后的急性和过敏性支气管收缩和晚期嗜酸性粒细胞聚集。BW B70C可防止白三烯C4的合成,减少白细胞向气道腔的迁移以及白蛋白微血管渗漏。BW B70C具有抗哮喘药物研究的潜力[1][2][3]。 |
英文名 | bw b70c |
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英文别名 | 更多 |
描述 | BW B70C是一种有效、选择性和口服活性花生四烯酸5-脂氧合酶抑制剂。BW B70C抑制豚鼠吸入过敏原后的急性和过敏性支气管收缩和晚期嗜酸性粒细胞聚集。BW B70C可防止白三烯C4的合成,减少白细胞向气道腔的迁移以及白蛋白微血管渗漏。BW B70C具有抗哮喘药物研究的潜力[1][2][3]。 |
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相关类别 | |
体内研究 | BW B70C(30 mg/kg;i.p.)可防止肺泡巨噬细胞合成白三烯C4,并减少白细胞向气道腔的迁移以及白蛋白微血管渗漏,但不影响内毒素诱导的TNF-α和分泌型磷脂酶A2血水平的升高[2]。 |
参考文献 |
密度 | 1.295g/cm3 |
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沸点 | 498.9ºC at 760 mmHg |
分子式 | C17H17FN2O3 |
分子量 | 316.32700 |
闪点 | 255.5ºC |
精确质量 | 316.12200 |
PSA | 75.79000 |
LogP | 4.48990 |
蒸汽压 | 8.96E-11mmHg at 25°C |
折射率 | 1.627 |
个人防护装备 | Eyeshields;Gloves;half-mask respirator (US);multi-purpose combination respirator cartridge (US) |
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安全声明 (欧洲) | S24/25 |
危险品运输编码 | NONH for all modes of transport |
RTECS号 | YT3976666 |
Lyprinol inhibits LTB4 production by human monocytes.
Allerg. Immunol. (Paris.) 32(7) , 284-9, (2000) The effect of Lyprinol was evaluated on LTB4-induced human monocytes (normal and allergic donors) activation. Peripheral blood normal monocyte-derived monocytes when stimulated by Interleukin-4 (IL-4)... |
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Participation of leukotriene C(4) in the regulation of suicidal erythrocyte death.
J. Physiol. Pharmacol. 60(3) , 135-43, (2009) Eryptosis, the suicidal death of erythrocytes, is characterized by cell shrinkage and cell membrane scrambling with phosphatidylserine exposure at the erythrocyte surface. Eryptosis is triggered by in... |
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Allergen-induced glycoconjugate secretion in guinea-pig trachea in vivo: modulation by indomethacin, BW B70C and ZD-2138.
Pulm. Pharmacol. 8(1) , 53-63, (1995) A method has been established for measurement of tracheal secretions in anaesthetized, ventilated guinea-pigs. The upper trachea was cannulated and perfused with saline. The perfusate was analysed for... |
70C |
1-[(E)-4-[3-(4-fluorophenoxy)phenyl]but-3-en-2-yl]-1-hydroxyurea |
N-[3-[3-4(-Fluorophenoxy)phenyl]-1-methyl-2-propenyl]-N-hydroxyurea |