57982-78-2

• 常用中文名：布地平
• 常用英文名：1-tert-butyl-4,4-diphenylpiperidine
• CAS号：57982-78-2
• 分子式：C₂₁H₂₇N
• 分子量：293.446
• 相关类别： 原料药 神经系统用药 抗震颤麻痹药
• 发布时间：2018-03-04 08:00:00
• 更新时间：2024-01-01 20:45:52
• Budipine是一种抗帕金森病剂。

名称

• 中文名: 布地平
• 英文名: 1-tert-Butyl-4,4-diphenyl-piperidine
• 中文别名: 布地品
• 英文别名: Piperidine, 1-(1,1-dimethylethyl)-4,4-diphenyl-; 1-(1,1-Dimethylethyl)-4,4-diphenyl-piperidine; 1-tert-butyl-4,4-diphenylpiperidine; 1-(2-Methyl-2-propanyl)-4,4-diphenylpiperidine

物化性质

• 密度: 1.0±0.1 g/cm3
• 沸点: 387.6±42.0 °C at 760 mmHg
• 熔点: 108.5°C
• 分子式: C₂₁H₂₇N
• 分子量: 293.446
• 闪点: 168.7±24.8 °C
• 精确质量: 293.214355
• PSA: 3.24000
• LogP: 4.64
• 蒸汽压: 0.0±0.9 mmHg at 25°C
• 折射率: 1.558
• 储存条件: 库房通风低温干燥,与食品原料类分开存放

生物活性

• 描述: Budipine是一种抗帕金森病剂。
• 相关类别:
  信号通路 >> 其他 >> 其他
  研究领域 >> 神经疾病
• 参考文献:

  [1]. Reichmann H, et al. Budipine in Parkinson's tremor. J Neurol Sci. 2006 Oct 25;248(1-2):53-5.

毒性和生态

CHEMICAL IDENTIFICATION RTECS NUMBER : TM7291100 CHEMICAL NAME : Piperidine, 1-(1,1-dimethylethyl)-4,4-diphenyl- CAS REGISTRY NUMBER : 57982-78-2 LAST UPDATED : 199612 DATA ITEMS CITED : 4 MOLECULAR FORMULA : C21-H27-N MOLECULAR WEIGHT : 293.49 WISWESSER LINE NOTATION : T6NTJ AX1&1&1 DR& DR HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 165 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 32,85,1982 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 28 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 32,85,1982 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 120 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 32,85,1982 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 33 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 32,85,1982

安全

• 海关编码: 2933399090

合成路线

1465-76-5 71-43-2 ~% 57982-78-2

文献：Arzneimittel-Forschung/Drug Research, , vol. 34, # 3 p. 233 - 240

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海关

海关编码	2933399090
中文概述	2933399090. 其他结构含非稠合吡啶环的化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%
申报要素	品名, 成分含量, 用途, 乌洛托品请注明外观, 6－己内酰胺请注明外观, 签约日期
Summary	2933399090. other compounds containing an unfused pyridine ring (whether or not hydrogenated) in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%